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  • 1
    Digitale Medien
    Digitale Medien
    Molecular genetics of inherited retinal degenerations
    Amsterdam : Elsevier
    Current Opinion in Genetics & Development 2 (1992), S. 459-466 
    Details
    ISSN: 0959-437X
    Schlagwort(e): [abr] AIED; Aland island eye disease ; [abr] CSNB; congential stationary night blindness ; [abr] HR; hereditary retinoschisis ; [abr] OA; ocular albinism ; [abr] OAT; ornithine aminotransferase ; [abr] OED; Oregon eye disease ; [abr] RP; retinitis pigmentosa ; [abr] RS; retinoschisis ; [abr] TCD; tapetochoroidal dystrophy ; [abr] XL; X-linked ; [abr] YAC; yeast artificial chromosome ; [abr] ad; autosomal dominant ; [abr] ar; autosomal recessive
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/S0959-437X(05)80158-3
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Molecular genetics of inherited retinal degenerations
    Amsterdam : Elsevier
    Current Opinion in Genetics & Development 2 (1992), S. 459-466 
    Details
    ISSN: 0959-437X
    Schlagwort(e): [abr] AIED; Aland island eye disease ; [abr] CSNB; congential stationary night blindness ; [abr] HR; hereditary retinoschisis ; [abr] OA; ocular albinism ; [abr] OAT; ornithine aminotransferase ; [abr] OED; Oregon eye disease ; [abr] RP; retinitis pigmentosa ; [abr] RS; retinoschisis ; [abr] TCD; tapetochoroidal dystrophy ; [abr] XL; X-linked ; [abr] YAC; yeast artificial chromosome ; [abr] ad; autosomal dominant ; [abr] ar; autosomal recessive
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/S0959-437X(05)80158-3
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats (1998)
    Springer
    Psychopharmacology 135 (1998), S. 361-367 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Key words Streptozotocin ; Experimental diabetes mellitus ; Anxiety ; Diazepam ; Brain monoamines ; Tribulin ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  The anxiolytic activity of diazepam (DZP) (0.25–1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various anxiety paradigms, including the open-field exploratory behaviour, elevated plus maze and elevated zero maze behaviours and the social interaction tests. In addition, rat brain tribulin activity was also assessed as a biochemical marker of anxiety. The results indicate that diabetic rats showed significantly more anxiogenic activity in comparison to non-diabetic rats on open-field, elevated plus maze, zero maze and social interaction tests. In diabetic rats, brain tribulin activity (MAO-A inhibitory component) was significantly increased. DZP dose dependently produced anxiolytic activity on the various behavioural parameters in non-diabetic rats. DZP (0.5 and 1 mg/kg) partially reversed the anxiogenic behaviour of STZ diabetic rats in elevated plus maze and zero maze tests. However, in open field behaviour and social interaction tests significant anxiolytic activity was observed only at a higher dose of DZP (1 mg/kg). The findings indicate that STZ-induced diabetic rats exhibited augmented anxiety on various experimental paradigms and that the anxiolytic effect of diazepam was less marked in diabetic rats as compared to their euglycaemic counterparts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002130050523
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  • 4
    Digitale Medien
    Digitale Medien
    Anxiolytic activity of ginkgolic acid conjugates from Indian Ginkgo biloba (1998)
    Springer
    Psychopharmacology 136 (1998), S. 148-152 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Key words Indian Ginkgo biloba (IGb) ; Ginkgolic acid conjugates ; EGb 761 ; Anxiety ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Ginkgolic acid conjugates (GAC) (6-alkylsalicylates, namely n-tridecyl-, n-pentadecyl-, n-hepta- decyl-, n-pentadecenyl- and n-heptadecenylsalicylates) isolated from the leaves of Indian Ginkgo biloba Linn., (IGb) were tested for their putative role in anxiety in rats. Elevated plus maze, open-field behaviour, novelty-induced feeding latency and social interaction were the rodent behavioural models used in this study. GAC (0.3 and 0.6 mg/kg, each, PO) on single acute administration, showed dose-related changes in the behaviour. GAC (0.6 mg/kg) and DZ augmented open arm entries, the open arm/closed arm entries ratio and increased time spent in the open arm on the elevated plus maze. In the open field, GAC (0.6 mg/kg) and DZ significantly increased ambulation and reduced the immobility time. EGb 761 showed a similar profile. GAC (0.6 mg/kg) and DZ significantly attenuated the increased latency to feed in novel environment. By contrast, EGb 761 and Ginkocer further augmented feeding latency. None of the drugs tested showed any significant effect in the social interaction test. GAC showed consistent and significant anxiolytic activity in all the variables investigated. By contrast, EGb 761 and Ginkocer, which are devoid of GAC, did not evoke significant activity. However, increased rearing and decreased immobility time only in open field behaviour shown by EGb 761 may be due to some antianxiety activity of a lesser degree. Our observations suggest that GAC may be the active constituents of Ginkgo biloba responsible for the anxiolytic activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002130050550
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