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  • 1
    Digitale Medien
    Digitale Medien
    Dihydrofolate reductase-activity in brain tissue (1987)
    Springer
    Annals of hematology 55 (1987), S. 483-488 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Dihydrofolate reductase ; Cranial irradiation ; Brain tissue
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The mechanism responsible for the toxic late effects of cranial irradiation, followed by the administration of systemic methotrexate (MTX) on brain tissue, is still under discussion. We studied the influence of X-irradiation on dihydrofolate reductase (E.C. 1.5.1.3) activity (DHFR), the enzyme inhibited by MTX. New Zealand white rabbits, 6–9 weeks old, underwent 24 Gy fractionated or 20 Gy single-dose brain irradiation using a 60Co source. Before, immediately following, and 1, 2, 4, 12 weeks after irradiation, DHFR was measured in brain and liver tissue by a photometric assay. DHFR in brain tissue was 11.9±2.9 mU/g wet weight (ww) × h and in liver tissue 121.8±24.2 mU/g ww × h. Fractionated brain irradiation with 2 Gy per day produced no significant changes in brain DHFR. Single-dose cranial irradiation significantly decreased brain DFHR (7.3±0.6 mU/g ww × h). Suppression of the developmental increase of DHFR by X-irradiation in young rabbits could be excluded by determining the unchanged brain-to-liver ratios of DHFR in the animals with fractionated brain irradiation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00320216
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