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Digitale Medien

Amphiphile induced echinocyte-spheroechinocyte transformation of red blood cell shape (1998)

Iglič, A. ; Kralj-Iglič, Veronika ; Hägerstrand, Henry

Springer

European biophysics journal 27 (1998), S. 335-339

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Details

ISSN: 1432-1017

Schlagwort(e): Key words Red blood cell ; Spheroechinocyte ; Membrane skeleton ; Cell shape ; Elastic energy

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Physik

Notizen: Abstract A possible physical explanation of the echinocyte-spheroechinocyte red blood cell (RBC) shape transformation induced by the intercalation of amphiphilic molecules into the outer layer of the RBC plasma membrane bilayer is given. The stable RBC shape is determined by the minimization of the membrane elastic energy, consisting of the bilayer bending energy, the bilayer relative stretching energy and the skeleton shear elastic energy. It is shown that for a given relative cell volume the calculated number of echinocyte spicula increases while their size decreases as the number of the intercalated amphiphilic molecules in the outer layer of the cell membrane bilayer is increased, which is in agreement with experimental observations. Further, it is shown that the equilibrium difference between the outer and the inner membrane leaflet areas of the stable RBC shapes increases if the amount of the intercalated amphiphiles is increased, thereby verifying theoretically the original bilayer couple hypothesis of Sheetz and Singer (1974) and Evans (1974).

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s002490050140

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