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Digitale Medien

Substance P-containing primary afferent receives inhibitory modulation directly from enkephalin- and GABA-containing interneurons in the dorsal horn of the chicken

Atsumi, S. ; Sakamoto, H. ; Kawate, T. ; [weitere]

Amsterdam : Elsevier

Regulatory Peptides 46 (1993), S. 410-412

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Details

ISSN: 0167-0115

Schlagwort(e): Chicken ; Enkephalin ; GABA ; Pain ; Primary afferent ; Spinal cord ; Substance P

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Medizin

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0167-0115(93)90103-F

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Digitale Medien

Species differences in the coexistence of 5-hydroxytryptamine and substance P in presynaptic boutons in the cervical ventral horn (1991)

Sakamoto, H. ; Atsumi, S.

Springer

Cell & tissue research 264 (1991), S. 221-230

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Details

ISSN: 1432-0878

Schlagwort(e): Substance P ; 5-Hydroxytryptamine (serotonin) ; Spinal cord ; Ventral horn ; Immuno-electron microscopy ; Chicken ; Rat (Wistar) ; Golden hamster ; Macaca fuscata

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Substance P (SP)-and 5-hydroxytryptamine (5-HT)-containing presynaptic boutons in the cervical ventral horn were studied in chicken, hamster, rat and monkey spinal cords, using PAP and protein A-gold double-labeling techniques in conjunction with monoclonal antibodies. In the chicken, the PAP method demonstrated that SP-immunoreactive boutons contained large spherical dense-cored vesicles (DCVs) whereas 5-HT-immunoreactive boutons displayed both elongated and spherical DCVs. Using the protein A-gold double-labeling technique, 10-nm gold particles for SP were localized over the spherical DCV-containing boutons whereas 15-nm gold particles for 5-HT were localized on elongated DCV-containing boutons. On the other hand, in the other species investigated, both SP-and 5-HT-immunoreactive boutons had similar morphological features as shown by the PAP method; both contained elongated and spherical DCVs. The two differentsized gold particles, each of which labeled either 5-HT or SP, were found together over DCVs in a single bouton. These results indicate that 5-HT and SP are contained in different presynaptic boutons in the chicken, although in the hamster, rat and Japanese macaque, the two neurotransmitters/modulators coexist in the same DCVs in a single bouton. Species differences have thus been demonstrated for the coexistence of 5-HT and SP in the spinal ventral horn.