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Digitale Medien

Bromperidol, a new butyrophenone neuroleptic: A review (1982)

Dubinsky, B. ; McGuire, J. L. ; Niemegeers, C. J. E. ; [weitere]

Springer

Psychopharmacology 78 (1982), S. 1-7

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Details

ISSN: 1432-2072

Schlagwort(e): Bromperidol ; Haloperidol ; Chlorpromazine ; Preclinical review ; Animal pharmacology ; Animal pharmacokinetics ; Animal biotransformation ; Animal drug safety

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract This review compares and contrasts the preclinical pharmacology of bromperidol with another butyrophenone neuroleptic, haloperidol, and the phenothiazine neuroleptic chlorpromazine. Its pharmacokinetics, biotransformation, and safety in several laboratory animal species are also summarized. These preclinical data support its use as an antipsychotic agent and show that it is well absorbed following oral administration with an apparent elimination half-life of approximately 24 h, supporting a once-daily dose regimen. Animal toxicity (including acute- and multiple-dose toxicology and reproductive and mutagenicity studies) show that bromperidol is well tolerated.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00470578

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