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Digitale Medien

Cyclosporin-associated nephropathy in patients with autoimmune diseases (1988)

Mihatsch, M. J. ; Bach, J. F. ; Coovadia, H. M. ; [weitere]

Springer

Journal of molecular medicine 66 (1988), S. 43-47

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Details

ISSN: 1432-1440

Schlagwort(e): Cyclosporin ; Nephropathy ; Side effects ; Autoimmune disease

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Renal biopsy specimens were evaluated from patients with different autoimmune diseases treated with cyclosporin (CyA). Ten biopsies were done before CyA, 10 biopsies after low-dose (〈7.5 mg/kg/day, initial dose or mean daily dose within the first month, respectively), and 9 after high-dose (〉7.5 mg/kg/day) treatment. Definite chronic CyA nephrotoxicity (cyclosporin-associated arteriolopathy and/or interstitial fibrosis striped form with tubular atrophy) was only present in the initial high-dose group. In this group a significant serum creatinine increase was noted and 8 of the 9 patients were hypertensive. No significant correlation was found between the severity of morphologic lesions and the mean daily dose during total treatment, cumulative dose, and duration of therapy. The morphologic changes in the low-dose group did not differ from the control biopsy specimens before CyA treatment. Based on these results, it can be concluded that major nephrotoxicity can be avoided by initial low CyA doses.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01713009

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