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  • 1
    Digitale Medien
    Digitale Medien
    Assessment of the in vitro broad-spectrum antiviral activity of some selected antitumor metallocene and metallocenium complexes (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 3 (1989), S. 491-497 
    Details
    ISSN: 0268-2605
    Schlagwort(e): Metallocenes ; metallocenium complexes ; antiviral activity ; DNA viruses ; RNA viruses ; HIV-1 ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Six neutral metallocenes and six metallocenium salts, all of which have demonstrated antiproliferative properties, were evaluated for their in vitro broad-spectrum antiviral properties and cytotoxicities. The metallocenes include the compounds (η-C5H5)2MCl2, Where M=Ti, V, Mo, Zr and Hf, and (η-C5H5)2Tibis(hydrogen maleinate), whereas the metallocenium complexes include the three ferrocenium salts, (η-C5H5)2Fe+X-, where X- = trichloroacetate, tetrachloroferrate(III) and picrate, and three recently discovered antitumor titanocenium complexes, i.e. [(η-C5H5)2Ti(CH3CN)Cl+] [FeCl4-], [(η-C5H5)2Ti(2,2′-bipyridyl)2+][CF3SO3-]2, and [(η-C5H5)2Ti(N-methyl-o-aminothiophenolate+)] [I-]. These 12 species were evaluated against DNA viruses (herpes simplex virus type 1, type 2 and vaccinia virus), and RNA viruses [vesicular stomatitis virus, Coxsackie virus B4, Sindbis virus, Semliki forest virus, parainfluenza virus type 3 and human immunodeficiency virus type 1 (HIV-1), the etiologic agent of AIDS]. In the case of HIV-1, the complexes were evaluated for their ability to inhibit HIV-associated reverse transcriptase activity and HIV-1 induced cytopathogenicity in human T-lymphocyte MT4 cells. Selectivity indexes [ratio of the minimum cytotoxic concentration (does) to the minimum (antiviral) inhibitory concentration (dose)] were determined for all complexes and viruses. In general, the netural metallocenes and the ferrocenium salts were only marginally active towards some specific viruses. However,[(η-C5H5)2Ti(bipy)22+] [CF3SO3-]2 was active towards the DNA viruses at a concentration that was ten times lower than the cytotoxicity threshold. (η-C5H5)2VCL2 was weakly inhibitory towards HIV reverse transcriptase. All species were ineffective in inhibiting HIV-induced cytopathogenicity in human T-lymphocyte MT4 cells.
    Zusätzliches Material: 4 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aoc.590030605
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  • 2
    Digitale Medien
    Digitale Medien
    Assessment of the in vitro broad-spectrum antiviral activity of some selected antitumor organotin complexes (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Applied Organometallic Chemistry 3 (1989), S. 431-436 
    Details
    ISSN: 0268-2605
    Schlagwort(e): Organotin complexes ; octahedral ; antitumor ; DNA viruses ; RNA viruses ; HIV ; Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Eleven antitumor-active octahedral organotin complexes of the type R2SnX2L2, where R = methyl, ethyl or phenyl, X = chloride or bromide, and L2 = o-phenantholine ((phen), 2-)2-(pyridyl)-benzimidazole (PBI) or two dimethylsulfoxides (2DMSO), were examined for their broad-spectrum in vitro antiviral activity against a number of DNA and RNA viruses. The DNA viruses included in this study were herpes simplex virus type 1 and type 2, a TK-(thymidine kinase deficient) strain of herpes simplex virus type 1, and vaccinia virus. The RNA viruses were vesicular stomatitis virus, Coxsackie virus type B4, Sindbis virus, Semliki forest virus, parainfluenza virus type 3, and human immunodeficiency virus (HIV). Overall, the complexes showed weak antiviral activity and low selectivity. With the exception of (CH3)2SnBr2·PBI and (C6H5)2SnCl2·2DMSO, all of the complexes were active against one or more of the three strains of herpes simplex viruses. On the other hand, only three complexes, (CH3)2SnBr2·PBI, (CH3)2SnBr2·phen, and (C6H5)5SnBr2·PBI, exhibited marginal activity against some of the RNA viruses. None of the complexes was active against vesicular stomatitis or parainfluenza virus. Similarly, there was no inhibitory activity towards HIV-1-associated reverse transcriptase or HIV-1-induced cytopathogenicity in human T-lymphocyte MT4 cell cultures at subtoxic concentrations.
    Zusätzliches Material: 4 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/aoc.590030509
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