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Digitale Medien

Early presentation in the mucopolysaccharide disorders (1996)

Colville, G A ; Bax, M A

Oxford, UK : Blackwell Publishing Ltd

Child 22 (1996), S. 0

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ISSN: 1365-2214

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin , Psychologie

Notizen: Summary The findings of an international questionnaire study of 258 children, affected by the four main subtypes of mucopolysaccharidosis, are presented. Questionnaires were completed by a parent or main carer and all subjects were alive at the time of contact and suffering from Hurler, Hunter, Sanfilippo or Morquio syndrome. A significant proportion of parents of Hurler children (24%) were unaware that anything was wrong with their baby before diagnosis but a larger number (45%) had felt concerned about their child's appearance. Similarly, in the case of the Morquio children, in 75% of cases, parents had been worried about some aspect of their child's physical appearance, in contrast, it was frequently delayed or regressing language which alerted parents of Sanfilippo (56%) and Hunter (32%) children, and this was associated with behaviour problems in 43% of Sanfilippo cases. There were many cases of delayed diagnosis, often occurring more than 2 years after concerns were first raised.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2214.1996.tb00420.x

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Digitale Medien

Rules for ritual challenges: A speech convention among medieval knights

Bax, M.

Amsterdam : Elsevier

Journal of Pragmatics 5 (1981), S. 423-444

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ISSN: 0378-2166

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Allgemeine und vergleichende Sprach- und Literaturwissenschaft. Indogermanistik. Außereuropäische Sprachen und Literaturen

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0378-2166(81)90027-8

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Digitale Medien

Quantitative determination of arecoline in plasma by gas chromatography chemical ionization mass spectrometry (1989)

Hayes, M. J. ; Khemani, L. ; Bax, M. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 18 (1989), S. 1005-1009

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ISSN: 0887-6134

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A capillary gas chromatography/mass spectrometry (GC/MS) method for the quantitative analysis of arecoline in plasma has been developed for concentrations in the range 1-50 ng ml-1. Hexadeuterated arecoline was utilized as the internal standard. The removal of drug from plasma was accomplished by a two-step liquid/liquid extraction procedure involving a wash step followed by extraction with 5% triethyl amine in ethyl acetate. The GC/MS determinations were carried out with temperature-programmed capillary GC and ammonia chemical ionization mass spectrometry. The [M + H]+ ions of both analyte and internal standard were monitored at m/z 156 and 162, respectively. The method is linear and has sufficient sensitivity, precision, accuracy and selectivity for analysis of drug levels in human plasma.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200181109

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