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  • 1
    Digitale Medien
    Digitale Medien
    Selectivity in the binding of psychotropic drugs to the variants of alpha-1 acid glycoprotein (1988)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 337 (1988), S. 220-224 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Alpha-1 acid glycoprotein ; Variants ; Equilibrium dialysis ; Drug binding
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The S- and F-forms of alpha-1 acid glycoprotein (AAG) variants have been isolated by isoelectric focusing with immobilines from commercially available AAG. In equilibrium dialysis experiments using a multicompartmental system, a higher affinity for various basic drugs has been found with S- in comparison with F-AAG: Amitriptyline, nortriptyline, imipramine, desipramine, trimipramine, methadone, thioridazine, clomipramine, desmethylclomipramine, and maprotiline. The selectivity (binding to S- vs. F-AAG) is the most pronounced for methadone and the lowest for thioridazine, while it is absent for the acidic drug mephenytoin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00169251
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  • 2
    Digitale Medien
    Digitale Medien
    Replacement of (R)-methadone by a double dose of (R, S)-methadone in addicts: interindividual variability of the (R)/(S) ratios and evidence of adaptive changes in methadone pharmacokinetics (1996)
    Springer
    European journal of clinical pharmacology 50 (1996), S. 385-389 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Key words Methadone; enantiomer ; metabolism ; induction ; opioid addicts
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Methods: Twenty-two patients receiving (R)-methadone maintenance treatment were switched to a double dose of (R, S)-methadone: blood samples were collected before and after the change, and the concentrations of the enantiomers were measured. In the second period, during racemic methadone treatment, important interindividual variability in the stereoselective disposition of the enantiomers of methadone was measured, with (R)/(S) ratios ranging from 0.63 to 2.40. This point should be taken into account particularly with respect to therapeutic drug monitoring of racemic methadone. Results: A significant decrease P 〈 0.005 in the mean serum concentration/dose ratios of the active (R)-enantiomer before and after the change was measured (mean 3.97 and 3.33). Conclusion: Although of small amplitude (16%), this decrease confirms previously described adaptive changes in methadone pharmacokinetics during racemic methadone maintenance treatment and may necessitate, in some patients, a dose adjustment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002280050128
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  • 3
    Digitale Medien
    Digitale Medien
    Orosomucoid (alpha-1 acid glycoprotein) phenotyping by use of immobilized pH gradients with 8M urea and immunoblotting (1988)
    Springer
    Human genetics 〈Berlin〉 80 (1988), S. 183-185 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Orosomucoid (ORM) phenotyping has been performed on 329 unrelated Swiss subjects, using immobilized pH gradients with 8M urea and 2% v/v 2-mercaptoethanol followed by immunoblotting. After desialylation the band patterns of ORM confirmed that the polymorphism of the structural locus ORM1 is controlled by three codominant autosomal alleles (ORM1*F1, ORM1*S and ORM1*F2). One rare and one new allele were detected. The rare variant, tentatively assigned to the second structural locus ORM2, is observed in a cathodal position and named ORM2 B1. The new variant, tentatively assigned to the first structural locus ORM1, is observed in a region located between ORM1 S and ORM1 F2, and named ORM1 F3. Moreover, the pI values of the ORM variants have been measured accurately with Immobiline Dry Plates (LKB): they were found to be within the pH range 4.93–5.14.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00702865
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  • 4
    Digitale Medien
    Digitale Medien
    Use of transgenic mice for the characterization of human alpha 1-acid glycoprotein (orosomucoid) variants (1989)
    Springer
    Human genetics 〈Berlin〉 84 (1989), S. 89-91 
    Details
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Sera from transgenic mice (TM) carrying human genes of α1-acid glycoprotein (orosomucoid or ORM) have been analyzed by isoelectrofocusing and subsequent immuno-blotting with antihuman ORM antibodies. With this technique it is possible to reveal selectively the human protein secreted in the TM sera. Orosomucoid bands present in TM sera have been compared with those of the most common human ORM phenotypes to correlate the products of specific genes to previously identified genetic variants. In this paper, we report the identification of the genes encoding for variants ORM1 F1 and ORM2 A, which are genes AGP-A and AGP-B/B′ respectively. The nucleotide sequences of these genes are known; therefore a direct correlation between variants and specific amino acid sequences can be established.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00210681
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