ISSN:
1432-0738
Keywords:
γ-Hexachlorocyclohexane
;
Tonic seizures
;
Brain and blood lindane levels
;
Toxicokinetics
;
Lindane dose-response relationship
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The relationships between brain and blood concentrations of lindane and its convulsant effects have been studied in rats after different po and ip doses. A good correlation was observed between dose and the frequency and time to onset of tonic seizures, the intensity of the response and lethality. An oral ED50 (84 mg/kg) and an ip ED50 (131 mg/kg) for the half-maximal incidence rate of lindane-induced tonic seizures was determined. The incidence of response was directly proportional to the log of lindane concentration in brain and blood, with an EC50 of 5.3 μg/g and 1.5 μg/ml, respectively. The threshold concentration of lindane eliciting tonic seizures was estimated to be ∼ 5 μg/g in brain and ∼ 1.5 μg/ml in blood. The kinetics of lindane in brain and blood were examined after a single 60 mg/kg po or ip dose over a period from 5 min to 1 week. Concentrations of lindane in brain and blood were found to be highly correlated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00302386
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