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  • 1
    Digitale Medien
    Digitale Medien
    Subtype-Specific Enhancement of NMDA Receptor Currents by Mutant Huntingtin (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 72 (1999), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Evidence suggests that NMDA receptor-mediated neurotoxicity plays a role in the selective neurodegeneration underlying Huntington's disease (HD). The gene mutation that causes HD encodes an expanded polyglutamine tract of 〉35 in huntingtin, a protein of unknown function. Both huntingtin and NMDA receptors interact with cytoskeletal proteins, and, for NMDA receptors, such interactions regulate surface expression and channel activity. To determine whether mutant huntingtin alters NMDA receptor expression or function, we coexpressed mutant or normal huntingtin, containing 138 or 15 glutamine repeats, respectively, with NMDA receptors in a cell line and then assessed receptor channel function by patch-clamp recording and surface expression by western blot analysis. It is interesting that receptors composed of NR1 and NR2B subunits exhibited significantly larger currents when coexpressed with mutant compared with normal huntingtin. Moreover, this effect was selective for NR1/NR2B, as NR1/NR2A showed similar currents when coexpressed with mutant versus normal huntingtin. However, ion channel properties and total surface expression of the NR1 subunit were unchanged in cells cotransfected with NR1/NR2B and mutant huntingtin. Our results suggest that mutant huntingtin may increase numbers of functional NR1/NR2B-type receptors at the cell surface. Because NR1/NR2B is the predominant NMDA receptor subtype expressed in medium spiny neostriatal neurons, our findings may help explain the selective vulnerability of these neurons in HD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1999.0721890.x
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  • 2
    Digitale Medien
    Digitale Medien
    Research on Creep Constitutive Model of TC11 Titanium Alloy Based on RBFNN (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 575-578 (Apr. 2008), p. 1050-1055 
    Details
    ISSN: 1662-9752
    Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Thema: Maschinenbau
    Notizen: The paper is aimed to exploit a creep constitutive mode of TC11 titanium alloy based onRBF neural network. Creep testing data of TC11 titanium alloy obtained under the same temperatureand different stress are considered as knowledge base and the characteristics of rheological formingof materials and radial basis function neural network (RBFNN) are also combined when exploitingthe model. A part of data extracted from knowledge base is divided into two groups: one is learningsample and the other testing sample, which are being performed training, learning and simulating.Then predicting value is compared with the creep testing value and the theoretical value deduced byprimary model, which validates that the RBFNN model has higher precision and generalizing ability
    Materialart: Digitale Medien
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.575-578.1050.pdf
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  • 3
    Digitale Medien
    Digitale Medien
    On the outer pressure problem of a viscous heat-conductive one-dimensional real gas (1997)
    Springer
    Acta mathematicae applicatae sinica 13 (1997), S. 251-264 
    Details
    ISSN: 1618-3932
    Schlagwort(e): Out pressure problem ; real gas
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We consider the outer pressure problem of the viscous heat-conductive, one-dimensional real gas, and prove the existence of globally defined smooth (large) solutions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02025881
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  • 4
    Digitale Medien
    Digitale Medien
    Existence of periodic solutions of nonlinear systems with nonlinear boundary conditions (1995)
    Springer
    Acta mathematica sinica 11 (1995), S. 439-445 
    Details
    ISSN: 1439-7617
    Schlagwort(e): Nonlinear parabolic systems ; Nonlinear boundary conditions ; Periodic solutions ; Semigroup
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract In this paper we consider the periodic solutions of nonlinear parabolic systems with nonlinear boundary conditions. By constructing the Poincare operator, we obtain the existence of $$W_p^{2\beta }$$ -periodic weak solutions under some reasonable assumptions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02248755
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