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  • 1
    Digitale Medien
    Digitale Medien
    Application of discrete Fourier transform to electron spin resonance spectral data (1975)
    s.l. : American Chemical Society
    Analytical chemistry 47 (1975), S. 1290-1293 
    Details
    ISSN: 1520-6882
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ac60358a040
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  • 2
    Digitale Medien
    Digitale Medien
    Pathologic Evaluation of Surgical Margins and Local Recurrences after Breast-conserving Surgery without Irradiation (2000)
    Springer
    World journal of surgery 24 (2000), S. 328-333 
    Details
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. This study was undertaken to evaluate the status of margins of the excised breast tissue using our own method. We also determined the indications for breast-conserving surgery without irradiation by examining the characteristics of patients with local recurrence and comparing relapse-free survival (RFS) and overall survival (OS) of patients who underwent wide excision without irradiation with those of 267 patients who underwent total mastectomy. Eighty-two patients with a 3 cm diameter or less invasive carcinoma were treated with wide excision and axillary dissection between 1987 and 1996. Patients who histologically had four or more axillary lymph node metastases, positive pathologic margins, or a high degree of in situ ductal carcinoma around the main tumor in consecutive step-sections were excluded from this study. During a median follow-up of 6 years (range 2–11 years), six patients (7.3%) had local recurrence and five (6.0%) had regional or distant recurrences as their site of first failure. At 11 years the life-table values for RFS and OS for the wide excision-treated group were 84.7% and 92.1%, respectively, compared with 85.0% and 90.0%, respectively, for patients treated by total mastectomy. RFS and OS were similar in the two treatment groups. Results in the present study indicate that if the patients treated by breast-conserving surgery are carefully selected and there are no foci in the pathologic margins, there is a low degree of in situ ductal carcinoma around the tumor, and no multicentricity, it might be unnecessary to administer radiation therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002689910052
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  • 3
    Digitale Medien
    Digitale Medien
    The methodology of quantitation of microvessel density and prognostic value of neovascularization associated with long‐term survival in Japanese patients with breast cancer (1999)
    Springer
    Breast cancer research and treatment 53 (1999), S. 19-31 
    Details
    ISSN: 1573-7217
    Schlagwort(e): breast cancer ; long‐term survival ; microvessel density ; neovascularization ; quantitation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The present study updates results on methodology of quantitation of tumor neovascularization and those on the prognostic value of microvessel density (MVD) in breast cancer tissue previously published in the World J. Surg. 21: 49–56, 1997. The follow‐up period of observation of the series was extended to 20 years, and new biological indicators (i.e., proliferating cell nuclear antigen (PCNA), c‐erbB‐2, and p53) were included in the analysis. There were 109 patients with primary breast cancer, from 1971 to 1979, followed up for a median of 14 years (range, 1–20). A representative median longitudinal section of each breast tumor was immunohistochemically stained with factor VIII‐related antigen and analyzed. The three methods of identifying MVD were: (1) average microvessel count (AMC)/mm2, (2) central microvessel count (CMC)/mm2, and (3) highest microvessel count (HMC)/mm2. Thirty‐one patients (28.4%) died of breast cancer. There was a relationship between MVD and peritumor blood vessel invasion (AMC: p = 0.0114, CMC: p = 0.0319, and HMC: p = 0.0009). However, there was no relationship between MVD and other factors. Univariate analysis showed that node status (p 〈 0.0001), histological grade (p 〈 0.0001), clinical tumor size (T) (p = 0.0002), PCNA (p = 0.0033), p53 (p = 0.0043), mitotic grade (p = 0.0092), AMC (p = 0.0214), and peritumor lymphatic vessel invasion (p = 0.0467) were significantly predictive of overall survival. HMC was borderline significant (p = 0.0702), while CMC and c‐erbB‐2 were not significant. Multivariate analysis showed that T (p = 0.0005), node status (p = 0.0053), and AMC (p = 0.0485) were independent factors, but neither CMC nor HMC was independent. AMC, a significant independent prognostic factor, might be a better method than the others for evaluating angiogenesis, but further and larger studies are warranted.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006193024382
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  • 4
    Digitale Medien
    Digitale Medien
    A case of pediatric cardiomyopathy with severely restrictive physiology (1992)
    Springer
    Heart and vessels 7 (1992), S. 206-210 
    Details
    ISSN: 1615-2573
    Schlagwort(e): Pediatric cardiomyopathy ; Restrictive physiology ; Hypertrophic cardiomyopathy ; Myocardial disorganization ; Square-root configuration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A rare case of a 6-year-old male with idiopathic familial cardiomyopathy manifesting severely restrictive physiology is reported. The patient showed congestive heart failure with dilatation of both atria with a normal ventricular cavity. A square-root configuration was revealed in the ventricular pressure tracings. His elder brother had died of hypertrophic cardiomyopathy at the age of 3 years. Endomyocardial biopsy disclosed marked disorganization of muscle bundles with hypertrophy of the myocytes and interstitial fibrosis. The patient died suddenly during hospitalization. Autopsy revealed diffuse hypertrophy of both the ventricular walls and the ventricular septum with extensive myocardial disorganization and interstitial fibrosis. These advanced myopathic changes in the myocardium may have been related to the restrictive physiology in this case.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01744606
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  • 5
    Digitale Medien
    Digitale Medien
    Ultrastructural features of the myocardium of children with dilated cardiomyopathy (1999)
    Springer
    Heart and vessels 14 (1999), S. 52-56 
    Details
    ISSN: 1615-2573
    Schlagwort(e): Endomyocardial biopsy ; Dilated cardiomyopathy ; Children ; Ultrastructure ; Basal lamina layering of capillary
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We analyzed the electron-microscopic features of endomyocardial biopsy from pediatric patients with dilated cardiomyopathy (DCM). The specimens examined were taken from the right ventricle of ten patients aged from 2 to 15 years (mean 9.7 years). Biopsy specimens from eight patients with congenital heart disease (tetralogy of Fallot), aged from 3 to 12 (mean 7.3 years), and ten adult patients with DCM, aged from 32 to 60 (mean 45 years), were also examined. Patients considered to have endocardial fibroelastosis, arrhythmogenic right ventricular cardiomyopathy, specific cardiomyopathy, or coronary heart disease were excluded from this study. Specimens from pediatric patients with DCM showed various degrees of ultrastructural abnormalities of myocytes, including myofibrillar fragmentation, mitochondrial abnormalities, and intracellular edema. The ultrastructurally determined contractility failure index based on the severity of myocardial degeneration at the electronmicroscopic level was 4.9 ± 1.1. This value was significantly higher than that in patients with tetralogy of Fallot (0.9 ± 0.6,P 〈 0.001) but was not significantly different from that in adult patients with DCM (6.1 ± 2.6). The index of pediatric patients with DCM who died within 3 years was high (6.0 ± 0.8). Basal lamina layering of a capillary (BLL) in the myocardium was revealed in 1 of the 10 (10%) pediatric patients with DCM and in 6 of the 10 (60%) adult patients with DCM (P 〈 0.05). No BLL was noted in the patients with tetralogy of Fallot. These findings may be related to the pathogenesis of DCM in children and adults.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02481742
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  • 6
    Digitale Medien
    Digitale Medien
    Distribution of desmin filaments in the myocardium of the failing heart (1994)
    Springer
    Medical molecular morphology 27 (1994), S. 246-248 
    Details
    ISSN: 1860-1499
    Schlagwort(e): Immunoelectron microscopy ; Dilated cardiomyopathy ; Immunocytochemistry ; Desmin filament
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Desmin filaments specific for muscle cells, normally localized at the Z band level and intercalated discs, may play an important role in maintaining the structure of the cardiomyocytes. By immunoelectron microscopy, we examined the distribution of desmin in endomyocardial biopsy samples of 10 patients with dilated cardiomyopathy. We found an increased number of desmin filaments characterized by a disordered arrangement in the myocytes. Desmin immunolabeling was transversely and longitudinally distributed at the Z band level and near the intercalated discs within the cytoplasm of the myocytes lacking myofilaments. These data suggest that desmin filaments could play a role in the defence mechanisms of the cardiomyocytes threatened by stress overloading in the diseased human heart.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02349666
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  • 7
    Digitale Medien
    Digitale Medien
    Book Review (1994)
    Springer
    Heart and vessels 9 (1994), S. 108-108 
    Details
    ISSN: 1615-2573
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01751945
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  • 8
    Digitale Medien
    Digitale Medien
    Contribution of cardiac muscle cell disorganization to the clinical features of hypertrophic cardiomyopathy (2000)
    Springer
    Heart and vessels 15 (2000), S. 149-158 
    Details
    ISSN: 1615-2573
    Schlagwort(e): Key words Hypertrophic cardiomyopathy ; Cardiac muscle cell disorganization ; Congestive heart failure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Heart failure rarely develops in the setting of hypertrophic cardiomyopathy (HCM). Because of this, cardiac muscle cell disorganization (CD), which is a histologic characteristic of HCM, is not believed to be responsible for the development of systolic dysfunction. The aim of the present study was to clarify whether CD can cause systolic dysfunction and ventricular dilation in patients with HCM. Sixteen hearts from patients with HCM obtained at autopsy were divided into two groups: group A (n = 11), without biventricular dilation, and group B (n = 5), with dilation. Specimens consisting of transverse and longitudinal tissue sections of the ventricles were prepared, and the extent of CD and interstitial fibrosis was quantified, using light microscopy. None of the patients in group A had had chronic congestive heart failure, while all of the patients in group B had died of congestive heart failure. In group B, CD was not limited to the interventricular septum. Rather, diffuse CD was observed in both ventricular free walls. The extent of CD was significantly greater in group B than in group A, while the degree of interstitial fibrosis was similar in the two groups (13.6% in group A vs 14.6% in group B). These results suggest that CD may be responsible for systolic dysfunction and ventricular dilation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003800070016
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  • 9
    Digitale Medien
    Digitale Medien
    Longer transplanted heart allograft survival in rats without immunosuppressants after intrathymic myocardial cell inoculation in the neonatal period (1993)
    Springer
    Heart and vessels 8 (1993), S. 67-70 
    Details
    ISSN: 1615-2573
    Schlagwort(e): Immune tolerance ; Thymus gland-immunology ; Heart transplantation ; Heart ; myocardium ; transplantation ; Graft survival ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In order to induce immunological tolerance, intrathymic inoculation of incompatible donor myocardial cells in rats was performed in the neonatal period. Isolated myocardial cells harvested from donor rat hearts were inoculated into the thymus of incompatible neonatal recipient rats without administration of immunosuppressive agents. Ten weeks later, the hearts from the donors were transplanted heterotopically to these pretreated rats. The animals were sacrificed on the 7th day of heterotopic transplantation and were examined histopathologically. The results showed no early rejection in the group in which intrathymic myocardial cell inoculation had been performed in the neonatal period. Immunohistochemical staining for myoglobin of the thymus from the inoculated recipient revealed that the donor myocardial cells continued to survive. The longest proven graft survival in this series, thus far, was 60 days, while it was only 7 days in the control group.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01744385
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  • 10
    Digitale Medien
    Digitale Medien
    Intravascular stents for management of pulmonary artery and right ventricular outflow obstruction (1994)
    Springer
    Heart and vessels 9 (1994), S. 40-48 
    Details
    ISSN: 1615-2573
    Schlagwort(e): Stent ; Balloon dilatation ; Pulmonary artery stenosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary This study was performed to determine the efficacy of balloon-expandable stents in the treatment of branch pulmonary artery-stenoses and conduit stenosis in children. A total of eight stainless steel stents were implanted in seven patients. Three patients had tetralogy of Fallot with pulmonary artery stenosis following total correction, one patient had conduit stenosis following correction of transposition of the great arteries, one patient had intra-cardiac conduit stenosis after septation for single left ventricle, and two patients had pulmonary artery stenosis after Fontan operation. Six stents were placed in the branch pulmonary arteries, one in the extracardiac conduit, and one in the intracardiac conduit. The mean age at implantation was 13 ± 3 years and the mean weight 37 ± 12kg. Follow-up time ranged from 0.3–2 years. The diameter of pulmonary arteries with stenoses increased from 5.6 ± 2.2 mm to 10.6 ± 1.8 mm (n = 7). The systolic pressure gradient decreased from 56 ± 26 mmHg to 22 ± 16 mmHg (n = 5). No embolization or thrombotic event has been noted. One stent placed in the intracardiac conduit was compressed and fractured. These data indicate that balloon-expandable stents are useful in the treatment of pulmonary artery branch stenoses and extracardiac conduit stenosis in children. The use of stents for intracardiac stenosis may result in stent fracture.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01744494
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