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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 1 (1953), S. 730-734 
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 22 (1950), S. 486-488 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 22 (1950), S. 845-846 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Diabetes in old age ; anaesthesia ; Tolbuta-mide ; insulin ; hypoglycaemia ; insulin resistance ; insulin allergy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Substitution of insulin for a dietary regime with or without oral hypoglycaemic agents prior to operation is, despite its general use, often not satisfactory because of lack of time and leads frequently to hypoglycaemia and sometimes to excessive insulin-antibody production. We therefore administered 1.0 g of Tolbutamidei.v. together with at least 100 g of carbohydrates per day to 36 non-insulin dependent diabetic patients, and compared the results with those of 28 similiar cases switched to insulin preoperatively in the usual way (I), and those of 27 patients receiving insulin before, during and after the operation (II). Interventions in the group on Tolbutamide i.v. (III) were more severe and lasted longer than those in the control groups. Blood-sugar levels on the operation day rose to 209 ± 76 mg% in the Tolbutamide group, (Control group I 203 ± 57, II 186 ± 52). Hypoglycaemia was observed in the control groups only. The method proposed avoids unnecessary insulin treatment and its consequences, and can be recommended, with correct selection of patients, for further evaluation during minor and more extensive operations.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-055X
    Keywords: Schlüsselwörter TIVA ; Propofol/Remifentanil ; Balancierte Anästhesie ; Sevofluran/Fentanyl ; Laparoskopie ; Gynäkologie ; Key words TIVA ; Propofol/Remifentanil ; Balanced anaesthesia ; Sevoflurane/Fentanyl ; Laparoskopy ; Gynaecology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Objective: This study was designed to investigate the differences between TIVA with propofol/remifentanil (P/R) and balanced anaesthesia with sevoflurane/fentanyl (S/F) in gynaecological laparoscopic surgery. Emphasis was put on haemodynamic reaction, recovery profile, postoperative side effects and patient satisfaction. Methods: Sixty patients were randomly assigned to receive either total intravenous anaesthesia with propofol/remifentanil or anaesthesia with sevoflurane/fentanyl. After premedication (midazolam) and induction of anesthesia (propofol, atracurium) in both groups, either 1 µg/kg fentanyl (S/F) or 1 µg/kg remifentanil (P/R) was injected. Anaesthesia was maintained with 0.5 µg/kg/min remifentanil (reduced to 50% after 5 min) and 0.06 µg/kg/min propofol (P/R) or 1.7 vol % sevoflurane (S/F). Both groups were mechanically ventilated with 30% oxygen in air. The administration of sevoflurane and the infusion of the anaesthetics were adjusted to maintain a surgical depth of anaesthesia. For postoperative analgesia 1 g paracetamol was administered rectally prior to surgery. After recovery 20 mg/kg metamizol was given intravenously. At the end of surgery the anaesthetics were discontinued and haemodynamics, early emergence from anaesthesia, pain level, frequency of analgesic demand, incidence of PONV, shivering and patient satisfaction were assessed. Parameters were recorded for 24 h postoperatively. Results: Recovery time after propofol-remifentanil anaesthesia was significantly shorter than after administration of sevoflurane and fentanyl (spontaneous ventilation 4.1 vs. 6.3 min, extubation 4.3 vs. 9.3 min, eye opening 4.4 vs 8.2 min, stating name 5.3 vs. 13.2 min, stating date of birth 5.4 vs. 13.3 min). There were no significant differences between the groups in shivering, pain score, analgesic demand and PONV. The S/F group responded to tracheal intubation with significantly higher blood pressure than the P/R group. During maintenance of anaesthesia heart rate in patients with S/F was significantly higher (P/R: HR max +16/–10; S/F: HR max +24/–0.). Measured on a scale from very satisfied to very dissatisfied, 73% of the patients in the P/R group were ”very satisfied” (S/F 23%) and 23% were ”satisfied” (S/F 62%). Conclusion: Compared with patients given balanced anaesthesia with sevoflurane and fentanyl, TIVA with propofol and remifentanil proved to be particularly suited for gynaecological laparoscopic surgery. Its major advantages are haemodynamic stability, significantly shorter times of emergence, and the exceptional acceptance by the patients.
    Notes: Zusammenfassung Fragestellung: Unterscheidet sich eine TIVA mit Remifentanil/Propofol (P/R) von einer balancierten Anästhesie mit Sevofluran/Fentanyl (S/F) hinsichtlich der Hämodynamik, des Aufwachverhaltens, postoperativer Nebenwirkungen und der Patientenzufriedenheit? Methodik: 60 Patientinnen wurden randomisiert einer Anästhesie mit (P/R) oder (S/F) zugeteilt. Nach oraler Prämedikation mit Midazolam wurde die Narkose mit Propofol eingeleitet, die Relaxierung erfolgte mit Atracurium. Gemäß randomisierter Gruppenzuteilung wurde 1 µg/kg Fentanyl oder 1 µg/kg Remifentanil i.v. injiziert und die Narkose bis zum OP-Ende entweder mit 0,5 µg/kg/h Remifentanil (Reduktion auf 50% nach 5 min) und mit 0,06 mg/kg/min Propofol oder mit 1,7 Vol.-% Sevofluran aufrechterhalten. Beide Gruppen wurden mit 30% O2 in Luft beatmet. Die Dosierung von Sevofluran, Propofol und Remifentanil wurden bei Bedarf der jeweiligen Intensität chirurgischer Stimuli angepaßt. Zur postoperativen Analgesie erhielten alle Patientinnen zu OP-Beginn 1 g Paracetamol rektal, nach Erwachen Metamizol 20 mg/kg i.v.. Bei OP-Ende wurde die Anästhetikazufuhr unterbrochen und folgende Parameter erfaßt: mittlerer arterieller Blutdruck, Herzfrequenz, Aufwachverhalten, Schmerzintensität, Analgetikabedarf, PONV, Muskelzittern und die Patientenzufriedenheit mit dem Anästhesieverfahren. Der Beobachtungszeitraum betrug 24 h. Ergebnisse: Die Patientinnen waren nach einer P/R Narkose signifikant eher wach und orientiert als nach einer Anästhesie mit S/F (Spontanatmung 4,1 vs. 6,3 min, Extubation 4,3 vs. 9,3 min, Augenöffnen 4,4 vs. 8,2 min, Namen nennen 5,3 vs. 13,2 min, Geburtsdatum 5,4 vs. 13,3 min). Die Inzidenz von PONV (43% vs. 43%) und Muskelzittern (56% vs. 37%) sowie die Schmerzintensität und die Anzahl der Schmerzmittelanforderungen (67 vs. 52) waren in beiden Gruppen vergleichbar. Der MAP war in der S/F-Gruppe nach der Intubation signifikant höher, die HF im gesamten Verlauf signifikant höher als in der P/R Gruppe (P/R: HF max. +16/–10; S/F: HF max. +24/–0). Auf einer Skala von „sehr zufrieden–sehr unzufrieden” waren 73% (P/R) der Patientinnen mit dem Anästhesieverfahren „sehr zufrieden” (S/F 23%), 23% „zufrieden” (S/F 62%). Schlußfolgerung: Verglichen mit einer balancierten Anästhesie mit Sevofluran und Fentanyl erwies sich die TIVA mit Remifentanil und Propofol als besonders vorteilhaft für laparoskopische Operationen in der Gynäkologie. Wesentliche Vorteile waren signifikant schnellere Aufwachzeiten, die hämodynamische Stabilität und die große Akzeptanz des Anästhesieverfahrens durch die Patientinnen.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0533
    Keywords: Skeletal muscle ; Denervation atrophy ; Target fibres ; Analysis of size distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An analysis of frequency distribution is performed in 250 target and targetoid fibres each from the anterior tibial muscle of a case with rapidly proceeding denervation atrophy. Following plane measurements on cross sections the size data were analysed according to the method of Daeves and Beckel [1] for mixed distributions. Three homogeneous normally distributed populations could thus be extracted from the mixed distributed sample. The largest population represents target fibres with a normal size range, while the second one encloses hypertrophic fibres, and the third and smallest one consists of fibres ranging within atrophic size limits. These findings support the previous presumption that targets predominantly occur in fibres of normal size and can therefore be regarded as manifestations of an early stage of denervation atrophy. The targetoid fibres, on the contrary, are of an atrophic size by 84%, while only a small population of about 15% contains targetoid fibres of a normal size on cross section.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0533
    Keywords: Neurofibromatosis 2 ; Bilateral acoustic neurofibromatosis ; Ghal hamartomas ; Immunohistochemistry ; S-100 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bilateral acoustic neurofibromatosis (neurofibromatosis 2, NF2) accounts for less than 10% of all cases of neurofibromatosis and manifests itself with bilateral acoustic schwannomas, multiple schwannomas of spinal nerve roots, meningiomas, glial tumors and hamartomatous CNS lesions. We have observed dysplastic foci of immature neuroectodermal cells in the cerebral cortex and basal ganglia of six patients afflicted with neurofibromatosis 2, ranging from occasional clusters of immature, dysplastic cells to numerous, confluent lesions. These cells, although often polymorphic and multinuclear did not show mitotic acitivity or a tendency for neoplastic transformation. To determine the histogenesis of these foci, extensive immunocytochemical reactions were carried out with antibodies to a variety of glial, neuronal and nonneural cell lineages. With the exception of S-100 protein, no immunoreactivity was detectable. S-100 was consistently expressed in these foci, irrespective of their size, location, and degree of polymorphism. On the basis of cytological appearance, distribution and immunoreactivity we tentatively designate these foci as glial micro-hamartomas. Although we did not systematically analyze the CNS of patients with von Recklinghausen neurofibromatosis (neurofibromatosis 1, NF1), the present study strongly suggests that these micro-hamartomas constitute a morphological hallmark of bilateral acoustic neurofibromatosis (NF2).
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0533
    Keywords: Thromboangiitis obliterans ; Dementia ; Cortical synaptophysin expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The generalized form of von Winiwarter-Buerger's disease (WBD) occasionally involves the brain. However, pure cerebral forms of the disease were also described by Spatz and Lindenberg (“Spatz-Lindenberg's disease”, SLD). Both, the type I, which involves the large basal arteries, and the type II, which results in a sickle-shaped granular atrophy of the cerebral cortex, are often accompanied by (“vascular”) dementia, which Lindenberg and Spatz mainly attributed to the bilateral involvement of the second frontal gyrus by granular atrophy. Recently, synaptic deprivation of the cortical gray matter has been shown to occur in the dementia of Alzheimer type (DAT) and other neurodegenerative disorders. In DAT, the synaptic loss highly correlated with the degree of the mental impairment. We wanted to examine whether similar changes also occurred in dementia of vascular origin, for which SLD, although infrequent, is a typical example. In fact, we found that in three cases of typical SLD type II the synaptophysin immunoreactivity of the cortical neuropil in areas without overt infarcts or scar formation was as much reduced as in Alzheimer's disease. Although it must be taken into account that in the present cases the synapse loss might, at least in part, be due to secondary (Wallerian) degeneration as a result of the neuronal loss in the “watershed” regions of the arterial blood supply, it cannot be excluded that a decline of cortical synaptic contacts in areas without necroses or scars may occur as a primary event, contributing to the pathogenesis of the dementia. Final conclusions can only be expected from investigations into further cases of cerebro-vascular disorders with and without dementia.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 57 (1982), S. 275-281 
    ISSN: 1432-0533
    Keywords: Spinal cord ; Conus medullaris ; Mixed chemodectoma and ganglioneuroma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Report of a 33-year-old man with a yearlong historory of low-back pain radiating into the left leg. Neurologic examination upon admission tto the hospital revealed a spinal compression syndrome at the lovel L5. Laminectomy at L4/5 revealed an encapsulated intradural tumor measuring 4×2.5×2.5 cm. The tumor was attached to the dorsal root L4 and extended downward to the conus region. Light and electron microscopy revealed features mostly consistent with a mixed chemodectoma and ganglioneuroma.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 75 (1988), S. 621-626 
    ISSN: 1432-0533
    Keywords: Angiomatosis ; Meningo-cerebral ; Congenital ; Necrotizing encepholopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Various observations of diffuse meningocerebral angiomatoses, which cannot be satisfactorily classified with the common phakomatoses, have been reported. They may occur at any age, with familial accumulation or sporadically. Divry and van Bogaert were the first to draw attention to such conditions in adults, where meningo-cerebral angiomatoses seemed to be combined with sudanophilic leukodystrophy. However, subsequently the latter was considered to be due to hypoxic damage to the white matter. In other observations, the severe damage to the grey matter was more evidently of hypoxic origin. Observations on two newborn individuals, sporadic examples of diffuse meningo-cerebral angiomatosis and with severe necrotic changes in the grey and white matter, are reported and discussed. Published reports on the various age-related forms are summarized and a general designation is suggested, which includes the various observations under a general heading. A parallel will be drawn between the meningo-cerebral angiomatosis and Foix-Alajouanin's disease.
    Type of Medium: Electronic Resource
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