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  • 1
    Digitale Medien
    Digitale Medien
    Localized amyloidosis of the uterine cervix (1988)
    Springer
    Virchows Archiv 413 (1988), S. 265-268 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Uterine cervix ; Amyloidosis ; Amyloid protein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Localized amyloidosis of the uterine cervix was found in a 56-year-old woman. The firm enlarged cervix showed massive tumorous amyloid deposition. In the amyloid deposits there were foci of ossification and calcification. An infiltrate of multinucleated giant cells, histiocytes, lymphocytes, and plasma cells was seen adjacent to the amyloid deposits. Immunohistochemically, the amyloid reacted with antisera against A-lambda, amyloid protein of immunoglobulin lambda light chain origin. This indicated that the amyloid protein was of immunoglobulin origin in this rare case of localized amyloidosis of the uterine cervix.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00718619
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  • 2
    Digitale Medien
    Digitale Medien
    Amyloid enhancing factor (AEF) in the aging mouse (1989)
    Springer
    Virchows Archiv 414 (1989), S. 511-514 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Amyloid ; Amyloidosis ; Amyloid enhancing factor ; Aging
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Amyloid enhancing factor (AEF) activity was tested in spleen homogenates from 52, 28, and 9-week-old untreated mice. Strong AEF activity was present in the supernatant of spleen homogenate from the 52-week-old mice. Only weak activity was observed in the supernatant from the 28-week-old mice, and none was seen in that from the 9-week-old mice. Crude spleen homogenates from the 52-week-old mice were subjected to Sephacryl S-300 gel filtration. AEF activity existed in the first gel filtration peak. These findings suggest that AEF increases in the spleens of aged mice and that AEF may be a substance of high molecular weight.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00781708
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  • 3
    Digitale Medien
    Digitale Medien
    Ultrastructural evidence for intracellular formation of amyloid fibrils in macrophages (1989)
    Springer
    Virchows Archiv 415 (1989), S. 411-419 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Amyloid ; Spleen ; Immunoelectron microscopy ; Intralysosomal formation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Early amyloid deposition in the spleen was studied by immunoelectron microscopy following the administration of rapid amyloid-inducing agents to mice. Two days after the injection of an amyloidenhancing factor and casein solution, a small amount of amyloid material was observed at the border of the white pulp and the marginal zone (perifollicular area) and also within the white pulp. At this stage, amyloid fibrils were seen mainly in an extracellular distribution along the cytoplasmic processes of reticular cells and also in the cytoplasmic invaginations of macrophages. By immunoelectron microscopy, gold particles labelled fibrillar structures in lysosome-derived organelles in some macrophages as well as dense bodies consisted of a homogeneous, granular matrix not having any recognizable fibrillar structures. Similar immunolabelled organelles were also observed in the amyloid resorption stage, although, at that stage, they commonly contained other phagocytized materials as well. From these findings, we suggest that at least some amyloid fibrils are polymerized in the cytoplasm of the macrophages by the proteolytic cleavage of previously pinocytized serum amyloid A protein (SAA).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00747742
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  • 4
    Digitale Medien
    Digitale Medien
    An ultrastructural study of the red pulp of the spleen and the liver in unstable hemoglobin hemolytic anemia (1977)
    Springer
    Virchows Archiv 374 (1977), S. 339-351 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Spleen ; Liver ; Heinz bodies ; Unstable hemoglobin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Electron microscopic observations on the process of red cell destruction in the spleen and liver of a patient with congenital Heinz body hemolytic anemia, associated with a new variant of unstable hemoglobin, are reported. Two major mechanisms of destruction of Heinz body-containing red cells were noted. One was phagocytosis of these cells in toto by cordal macrophages. The other mechanism, though less significant quantitatively, was intravascular hemolysis of injured red cells in the splenic microvasculature. In the liver, phagocytosis of damaged red cells by Kupffer cells was rare and there was no evidence of intravascular hemolysis in this organ. These morphological findings, together with almost complete recovery from hemolysis following splenectomy, indicated that Heinz body-containing red cells were removed from the circulation predominantly by the spleen. In contrast to experimental Heinz body anemia in animals, Heinz bodies were present even in the nucleated red cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00432655
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  • 5
    Digitale Medien
    Digitale Medien
    Erythrophagocytosis by the sinus endothelial cell of the spleen in haemolytic anaemias (1979)
    Springer
    Virchows Archiv 382 (1979), S. 261-269 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Spleen ; Sinus endothelial cell ; Erythrophagocytosis ; Haemolytic anaemias
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary An ultrastructural study of spleens from patients with a heterogeneous group of haemolytic anaemias was undertaken in order to determine whether sinus endothelial cells have erythrophagocytic ability. In most cases, sinus endothelial cells contained erythrocytes and various stages of intracellular degradation of engulfed erythrocytes were noted. Though the frequency of erythrophagocytosis varied from case to case, phagocytosis of erythrocytes by the endothelial cell was more frequent in cases in which cordal macrophages showed active erythrophagocytosis. These results suggest that the sinus endothelial cells have erythrophagocytic ability in certain pathological states, especially when the demands for the removal of defective erythrocytes are increased. However, the bulk of erythrophagocytosis is carried out by cordal macrophages, and endothelial phagocytosis has a minor significance in the development of haemolytic anaemia. Two possible processes by which erythrocytes come into contact with sinus endothelial cells are suggested.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00430402
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  • 6
    Digitale Medien
    Digitale Medien
    Localized amyloidosis in squamous cell carcinoma of uterine cervix: Electron microscopic features of nodular and star-like amyloid deposits (1993)
    Springer
    Virchows Archiv 422 (1993), S. 225-231 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Amyloid ; Amyloidosis ; Squamous cell carcinoma ; Keratin ; Ultrastructure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract An ultrastructural study of amyloid deposits in four cases of squamous cell carcinoma of uterine cervix was performed. The amyloid deposits reacted with anti-keratin antiserum on frozen sections. Amyloid deposits showed nodular (4 cases) and star-like forms (3 cases). Nodular amyloid deposits were composed of slightly whorled fibrils, measuring 7–10 nm in width. Some of them contained cellular debris and thicker, more electron-dense filaments than amyloid fibrils. In three cases, filamentous tumour cells and filamentous masses were observed together with amyloid. Star-like amyloid deposits were composed of bundles of straight amyloid fibrils. Some of the tumour cells in contact with star-like amyloid deposits had deep cytoplasmic invaginations, where closely packed amyloid fibrils were arrayed in parallel fasion. In addition, a few tumour cells had membrane-bound amyloid fibrils in the cytoplasm. It is suggested that nodular amyloid deposits are derived from the tumour cells through filamentous degeneration. Amyloid fibrils in star-like amyloid deposits are thought to be formed within the cytoplasm or in the vicinity of invaginated cytoplasmic membranes of the tumour cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01621806
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  • 7
    Digitale Medien
    Digitale Medien
    Morphological evaluation of amyloid-laden arteries in leptomeninges, cortices and subcortices in cerebral amyloid angiopathy with subcortical hemorrhage (1993)
    Springer
    Acta neuropathologica 86 (1993), S. 418-421 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Amyloid angiopathy ; Cerebral hemorrhage ; Elderly person
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To investigate the relationship between cerebral amyloid angiopathy and subcortical (lobar) hemorrhage, we examined the severity of amyloid deposition in the leptomeningeal, cortical and subcortical arteries in 28 autopsied elderly patients with cerebral amyloid angiopathy with subcortical hemorrhage, deep cerebral hemorrhage or without hemorrhage. The severity was evaluated in terms of the frequency of amyloid-laden arteries and the degree of amyloid deposition within the arteries. The frequency of amyloid-laden arteries, especially among arteries over 200 μm in diameter, was higher in subcortical hemorrhage group than in the deep hemorrhage group and the non-hemorrhage group, and when the degree of amyloid deposition in the arteries was divided into four grades (none, mild, moderate or severe), the severity was higher in the subcortical hemorrhage group than in the deep cerebral hemorrhage group and the non-hemorrhage group. These results suggest that severe cerebral amyloid angiopathy is related to non-traumatic subcortical hemorrhage in elderly persons.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00228574
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  • 8
    Digitale Medien
    Digitale Medien
    Effects of dimethyl sulfoxide and colchicine on the resorption of experimental amyloid (1979)
    Springer
    Virchows Archiv 384 (1979), S. 45-52 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Amyloid ; Resorption ; Dimethyl sulfoxide ; Colchicine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The induction of amyloid in C3H mice by either casein solution or complete Freund's adjuvant emulsion with Mycobacterium butyricum was confirmed by partial splenectomy. The animals were autopsied after treatment w ith dimethyl sulfoxide (550 mg/kg, 50 times), colchicine (0.02 mg/kg, 15–37 times), or saline solution as a control. Detailed histological comparisons of biopsy and autopsy spleens provided evidence that dimethyl sulfoxide was significantly effective in the resorption of amyloid, while in the animals treated with colchicine amyloid deposition was increased. The effect of dimethyl sulfoxide was discussed with reference to the modification of amyloid fibrils.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00427150
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