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  • 1
    Publication Date: 2021-03-16
    Language: English
    Type: article , doc-type:article
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 152-153 (Mar. 1994), p. 391-0 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 152-153 (Mar. 1994), p. 387-390 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 7 (1977), S. 437-442 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The activity of histidine-decarboxylase (HD) and histamine-N-methyl-transferase (HMT) was studied in the hypothalamus and cerebral cortex of rats from birth to adulthood. Development patterns were compared in sea-level controls and in rats born and maintained continuously in a natural hypoxic environment (at a high altitude of 3800 m, PO 2 13%) to determine whether chronic stress alters the development of the enzymes for histamine. When expressed in terms of total activity, both enzyme activities were low at birth and progressively increased with age in the two areas studied. When expressed in terms of specific activity, the developmental pattern of the enzymes better reflected that of histamine: for example, at birth, high HD activity and low HMT corresponded to high histamine levels; at 7 days, low HD activity and high HMT corresponded to low histamine levels. It is suggested that a feedback mechanism may operate between endogenous histamine levels and the activity of its synthesizing and catebolizing enzymes. Exposure to chronic stress failed to alter enzymatic activity during the first postnatal week, but significantly influenced it in later development and adulthood. In the hypothalamus stress induced HD activity in the developing animals but depressed it in the adults. In the cerebral cortex, HMT rather than HD was stimulated by stress, but here again the effects were age-dependent. The sensitivity of histaminergic enzymes to environmental stimulation provides indirect supportive evidence for neurotransmitter role of histamine.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 7 (1977), S. 177-181 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The activity of histidine-decarboxylase (HD) and histamine-N-methyl transferase (HMT) was studied in the hypothalamus and cerebral cortex of rats from birth to adulthood. Developmental patterns were compared in sea level controls and in rats born and maintained continuously in a natural hypoxic environment (at a high altitude of 3800 m, PO2 13%) to determine whether chronic stress alters the development of the enzymes for histamine. When expressed in terms of total activity, both enzyme activities were low at birth and progressively increased with age in the two areas studied. When expressed in terms of specific activity, the developmental pattern of the enzymes better reflected that of histamine: for example, at birth, high HD activity and low HMT corresponded to high histamine levels; at 7 days, low HD activity and high HMT corresponded to low histamine levels. It is suggested that a feedback mechanism may operate between endogenous histamine levels and the activity of its synthesizing and catabolizing enzymes. Exposure to chronic stress failed to alter enzymatic activity during the first postnatal week, but significantly influenced it in later development and adulthood. In the hypothalamus, stress induced HD activity in the developing animals but depressed it in the adults. In the cerebral cortex, HMT rather than HD was stimulated by stress, but here again the effects were age-dependent. The sensitivity of histaminergic enzymes to environmental stimulation provides indirect supportive evidence for neurotransmitter role of histamine.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 41 (1985), S. 407-408 
    ISSN: 1420-9071
    Keywords: Rat, stomach strips, isolated ; serotonin receptors, peripheral ; androgen-sensitive contraction ; estrogen-refractory contraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The maximal contraction provoked by serotonin (5-HT) in isolated stomach strips of adult rats, a functional index for peripheral 5-HT receptors, was sexually differentiated, androgen-sensitive, and estrogen refractory. This is at variance with the reported sensitivity of central 5-HT receptors to estrogen.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The neurotoxin 1-methyl-4-phenylpyridinium ion (MPP+) in the brain striatum has recently been shown to bind at a putatively vesicular site labeled by [3H]tyramine ([3H]TY). Whereas in the rat and mouse striatum MPP+ antagonized TY binding competitively, in the cerebellum there was a mixed-type antagonism, which suggests the simultaneous occupancy of two different sites. Ki values from displacement curves revealed a fourfold difference in the affinity of MPP+ for TY sites in the two brain regions. The degeneration of central noradrenergic terminals induced by an intraperitoneal injection of the toxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine in rats decreased by 80% the maximal number of cerebellar TY binding sites, while not affecting striatal binding. Furthermore, guanethidine, a marker for noradrenaline (NA) vesicles, potently inhibited TY binding in NA-innervated regions, such as the cerebellum and the parietal cortex, and poorly in the striatum. It is concluded (a) that both MPP+ and TY may also label NA vesicles and (b) that the vesicular carriers for dopamine and NA have different characteristics, which may underlie a regional specificity in the rate of endovesicular sequestration of MPP+, with either neurodegenerative or neuroprotective consequences, depending on the brain area involved.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 37 (1982), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The sex-dependent differentiation of monoamine oxidase (MAO) in the hypothalamus of 60-day-old, Charles River rats was found to involve only type A (MAO-A), and not type B (MAO-B) enzyme. In vivo inhibition of type A by clorgyline, and type B by (−)deprenyl, however, tended to decrease the specific activity of both types of MAO to a smaller extent in the female than in the male hypothalamus. When masculinization was prevented by neonatal administration of estradiol (E) to males, hypothalamic MAO-A and MAO-B activities increased in both control and MAO-inhibited rats. Androgenization of females, however, had little effect on the MAO activity. Whereas the effects of neonatal estrogenization were attributable neither to a direct influence of E nor to a sexual difference in the peripheral clearance of the MAO-inhibitor used, single, high doses of steroids to adult, but not to newborn rats, did acutely affect the kinetics of MAO-A. The activity of MAO-A was also decreased by high concentrations of E or TS in vitro. The imprinting for patterns of hypothalamic MAO-A and MAO-B in the two sexes results, probably, from genetic predetermination. Neonatal changes in the homeostasis of gonadal hormones may result in type-MAO nonspecific effects in adulthood, whereas the short-term effects of high concentrations of steroids may be selective for the A form.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of food science & technology 16 (1981), S. 0 
    ISSN: 1365-2621
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The conditions have been determined for achieving an effective separation on acid alumina of polyhydroxylated anthocyanins from others.The adsorption isotherms for some anthocyanins are also given and the behaviour of methanol, ethanol and propanol solutions has been examined.
    Type of Medium: Electronic Resource
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