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Digitale Medien

N-ethylmaleimide antagonizes stress-induced gastric ulcers in rats (1991)

Garg, G. P. ; Cho, C. H. ; Ogle, C. W.

Springer

Cellular and molecular life sciences 47 (1991), S. 250-251

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Details

ISSN: 1420-9071

Schlagwort(e): N-ethylmaleimide ; cold-restraint gastric ulcers ; sulfhydryl substances

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary N-ethylmaleimide (NEM) 10 or 25 mg/kg b.wt, given s.c. 20 min beforehand, dose-dependently and significantly antagonizes the severity of gastric glandular ulcers produced by restraint at 4°C (stress) for 2 h. These findings suggest that reduced activity of endogenous nonprotein sulfhydryl substances in gastric tissue does not worsen stress-induced ulceration in rat stomachs, unlike the deleterious effect its depletion is claimed to have on ethanol-evoked gastric mucosal damage. Thus, decreased SH activity appears not to play a role in the aetiology of mucosal ulcers due to stress.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01958150

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