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  • 1
    Digitale Medien
    Digitale Medien
    Neuroendocrine evidence for serotonin receptor hypersensitivity in panic disorder (1988)
    Springer
    Psychopharmacology 96 (1988), S. 360-364 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Serotonin ; Receptor hypersensitivity ; Anxiety ; Cortisol ; Panic disorder ; MCPP
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Normal controls (NC) (n=15), patients with panic disorder (PD) (n=13) and patients with major depression (MD) (n=17) were challenged with a single, oral dose (0.25 mg/kg) of the selective 5HT agonist m-chlorophenyl-piperazine (MCPP) or placebo. Blood samples were assayed for cortisol and MCPP levels every 30 min. The PD group had an augmented cortisol release when compared to the other two groups. Finally, a significant correlation was found across all subjects between clinical anxiety level and cortisol release on MCPP. These data support the hypothesis of 5HT receptor hypersensitivity in PD.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00216062
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    A dose-response study of intravenousm-chlorophenylpiperazine in normal subjects (1992)
    Springer
    Psychopharmacology 106 (1992), S. 388-390 
    Details
    ISSN: 1432-2072
    Schlagwort(e): MCPP ; Serotonin ; Dose-response ; Intravenous
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A placebo-controlled dose-response study of the direct serotonin receptor agonistm-chlorophenylpiperazine (MCPP), intravenously infused over 90 s in 0.06 and 0.08 mg/kg doses, was conducted in nine normal male subjects. Cortisol, prolactin, MCPP serum levels and behavioral responses were measured over a 210-min period. Both doses caused significant cortisol and prolactin release and were associated with significantly greater behavioral effects as compared to placebo. Though the two doses were associated with different MCPP serum levels, they did not significantly differ in their hormonal and behavioral effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02245423
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Artikel (Nationallizenzen)
    Volltext
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