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  • 1
    Electronic Resource
    Electronic Resource
    Crosstalk canceling for laser-assisted magnetic recording (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 415-417 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A promising method of crosstalk canceling is proposed for laser-assisted magnetic recording, which makes it possible to record and read with a narrow track pitch limited to nearly the size of a focused laser spot. In this method, a track pitch narrower than the laser spot size is obtained by utilizing the canceling of the leakage flux from an adjacent track. We achieved a crosstalk of −24 dB or less with a 0.7 μm track pitch in laser-assisted magnetic recording by using a laser spot size of 1.07 μm in diameter and a magnetoresistive head with a track width of 1.4 μm. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126994
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  • 2
    Electronic Resource
    Electronic Resource
    Characteristics of strengthened Ag substrates for Bi2Sr2CaCu2Ox doctor-bladed tapes (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 912-914 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The characteristics of Ag-(Mg,Ni) and Ag-Mn alloys as substrate materials for Bi2Sr2CaCu2Ox (Bi-2212) tapes and their influence on the superconducting properties were studied. Alloying with Mg+Ni or Mn drastically decreased the grain size of Ag after heat treatment. The additives in Ag-(Mg,Ni) and Ag-Mn alloys were oxidized during heat treatment in air. Both the fine grain structure and the internal oxidation of the additives increased the mechanical strength of the Ag alloys. Both alloys were 3–6 times stronger than pure Ag. The superconducting properties of Bi-2212 prepared on these Ag alloys were slightly degraded; however the critical current densities at 4.2 K in 8 T were still well over 104 A/cm2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.111962
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  • 3
    Electronic Resource
    Electronic Resource
    Characteristics of Ag-Au alloy sheathed Bi-Pb-Sr-Ca-Cu-O superconducting tapes for current leads (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 1304-1305 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Oxide superconductor tape with Ag-Au sheath was studied for current leads. A 100-cm-long current lead of 1000 A with 0.2 W/kA heat leakage was designed using Ag-11 at. % Au alloy sheath with low thermal conductivity. The overall current density of the superconducting tape is required to be 350–770 A/cm2 at 77 K when the superconductor cross-section ratio in the tape is 0.35–0.7. Bi-Pb-Sr-Ca-Cu-O superconducting tape with Ag-11 at. % Au alloy sheath was fabricated and the critical current density Jc was measured. The overall-Jc was 1700 A/cm2 at 77 K under 0 T. The possibility of the current lead of 1000 A under 0.28 T with 0.2 W/kA was made clear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.111917
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of Ag-Au and Ag-Cu alloys on Bi2Sr2CaCu2Ox superconductor (1994)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 112-114 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The influence of Ag-Au and Ag-Cu alloy substrates on the microstructure and superconducting properties of Bi2Sr2CaCu2Ox (Bi-2212) was studied. The critical current density (Jc) of Bi-2212/(Ag-Au) was not degraded by increasing the Au content of the Ag-Au alloy, while the Jc of Bi-2212/(Ag-Cu) was drastically degraded by increasing the Cu content of the Ag-Cu alloy. The microstructure of Bi-2212 on the Ag-Au alloy was uniform and no precipitates were observed. The Jc degradation of Bi-2212 in contact with the Ag-Cu alloy was understood by the fact that Cu absorption of Bi-2212 from the Ag-Cu alloys changed the composition of the oxide layer. Ag-Au alloys are superior substrate materials for Bi-2212 for power current leads for superconducting magnets, taking into account their low thermal conductivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.110895
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of twisting on strain tolerance of Bi-2212 multifilamentary round wires (1999)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 85 (1999), S. 2437-2440 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Silver sheath Bi2Sr2Ca1Cu2Ox superconducting multifilamentary round wires having various twist pitch lengths and an untwisted one were fabricated by the oxide powder-in-Ag-tube method. The twisting process to a pitch length of 4.5 mm at a diameter of 1.45 mm did not influence the superconducting critical current density Jc whose value was about 90 000 A/cm2 at 4.2 K, 0 T. The Jc of the twisted wires is less sensitive to bending strain as twist pitch length becomes shorter. This phenomenon is explained by the calculated results that the filament's curvature, which is added by the bending, becomes less as pitch length becomes shorter. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.369563
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  • 6
    Electronic Resource
    Electronic Resource
    Establishment of Animal Model of Antigen-Specific T Lymphocyte Recruitment into Nasal Mucosa (2002)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 56 (2002), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: DO11.10 transgenic mice, expressing an ovalbumin (OVA)-specific αβ T-cell receptor (TCR), have been used as a model of various immune diseases associated with T lymphocytes. Some studies of immunoresponse in lung have involved adoptive transfer of DO11.10 mice. As of yet, however, there have been no studies of the adoptive transfer model in the upper airway. The purpose of this study was to establish an animal model to clarify the recruitment mechanism and the roles of Th2 cells in allergic rhinitis. In accordance with the adoptive transfer system, we generated Th0, Th1 and Th2 cells from DO11.10 mice and transferred them into wild type BALB/c mice. Following nasal OVA challenge to DO11.10 mice or to the BALB/c mice into which antigen-specific Th2 cells had been transferred, the number of local antigen-specific TCR-positive cells accompanying the local eosinophilia had significantly increased. However, nasal OVA challenge to BALB/c mice into which antigen-specific Th0 or Th1 cells were transferred failed to increase the number of local OVA-specific TCR positive cells. These observations suggest that an antigen-specific homing mechanism of Th2 cells may exist in nasal mucosa. Analysis of this model will assist in the development of new therapeutic strategy, which targets Th2 cells in allergic rhinitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2002.01136.x
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  • 7
    Electronic Resource
    Electronic Resource
    Expression and localization of the cysteinyl leukotriene 1 receptor in human nasal mucosa (2002)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 32 (2002), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The cysteinyl leukotrienes (CysLT) are lipid mediators that have been implicated in the pathogenesis of allergic diseases. Pharmacological studies using CysLTs indicate that two classes of receptors, named CysLT1 and CysLT2 receptor, exist. The former is sensitive to the CysLT1 antagonist currently used to treat asthma and allergic rhinitis. Recently, the cDNA for human CysLT1 and CysLT2 receptor have been cloned, making it now possible to study the gene expression of CysLTs receptors.Objective We have used reverse transcription and polymerase chain reaction (RT-PCR) to study the gene expression of CysLT1 and CysLT2 receptor and in situ hybridization to determine the distribution of CysLT1 receptor mRNA in human nasal mucosa. In addition, the distribution of the CysLT1 receptor protein was studied by immunohistochemistry.Methods Human turbinates were obtained after turbinectomy from six patients with nasal obstruction refractory to medical therapy. Total RNA was isolated from human nasal mucosa and both CysLT1 and CysLT2 receptor mRNA was detected in these tissues by using RT-PCR. For in situ hybridization study of human nasal mucosa, we used biotin-labelled oligonucleotides probes encoding human CysLT1 receptor cDNA. To identify the cells expressing the CysLT1 receptor protein, double immunostaining was performed by using anti-CysLT1 receptor antibody and monoclonal antileucocyte antibodies.Results RT-PCR analysis of total nasal RNA demonstrated the expression of both CysLT1 receptor and CysLT2 receptor mRNA. In situ hybridization indicated high levels of CysLT1 receptor hybridization in blood vessels and the interstitial cells, but a sparse signal in airway epithelium and submucosal glands. The immunohistochemical studies revealed that anti-CysLT1 receptor antibody labelled eosinophils, mast cells, macrophages, neutrophils and vascular endothelial cells in the nasal mucosa.Conclusion The results may have an important clinical implication and also promote further investigation of the regulation of CysLT1 receptor in health and disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2002.01425.x
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of glucocorticosteroids on tumour necrosis factor-α-induced intercellular adhesion molecule-1 expression in cultured primary human nasal epithelial cells (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective In order to confirm the direct effect of glucocorticosteroids on epithelial intercellular adhesion molecule-1 (ICAM-1) expression, we examined ICAM-1 expression on primary cultured human nasal epithelial cells (HNECs) at both protein and mRNA levels.Material and methods HNECs were stimulated with recombinant human TNF-α (20 pg/mL–20 ng/mL) for specified time periods (0, 12, 24, and 48 h) and ICAM-1 mRNA and the soluble ICAM-1 (sICAM-1) concentrations were measured by quantitative RT-PCR and ELISA, respectively. We also evaluated surface expression of ICAM-1 by flow cytometry 48 h after stimulation and determined the effect of dexamethasone (DEX) on TNF-α-induced ICAM-1 expression.Results Significant increases in ICAM-1 gene expression in HNECs were initially detected at 24 h, peaking at 48 h after the stimulation. The TNF-mediated-ICAM-1 mRNA and ICAM-1 surface expression at 48 h was significantly inhibited by co-incubation with human recombinant soluble TNF receptor I. Similarly, TNF-α-induced release sICAM-1 occurred in a time- and concentration-dependent manner. DEX 10−6 m attenuated the TNF-α-induced ICAM-1 expression at mRNA and protein levels.Conclusions Our finding suggests a potential role for topical steroids in allergic rhinitis in suppressing inflammatory reactions in the nasal mucosa by regulating ICAM-1 expression on nasal epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.01964.x
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  • 9
    Electronic Resource
    Electronic Resource
    Mechanisms responsible for long-term survival of adult rat hepatocytes in the presence of phenobarbital in primary culture
    Amsterdam : Elsevier
    Experimental Cell Research 182 (1989), S. 415-424 
    Details
    ISSN: 0014-4827
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0014-4827(89)90246-2
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  • 10
    Electronic Resource
    Electronic Resource
    Effects of various substrates on human hepatoblastoma and hepatoma cell culture
    Amsterdam : Elsevier
    Cell Biology International Reports 12 (1988), S. 131-142 
    Details
    ISSN: 0309-1651
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0309-1651(88)90127-0
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