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  • 1
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid pharmacokinetics of carboplatin in children with brain tumors (1992)
    Springer
    Cancer chemotherapy and pharmacology 30 (1992), S. 21-24 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of carboplatin in cerebrospinal fluid (CSF) and plasma was studied in five children with brain tumors (four medulloblastomas and one ependimoblastoma) who underwent preirradiation treatment with carboplatin. Carboplatin pharmacokinetics was studied following the administration of 600 mg/m2 as a 1-h infusion. Four children were treated a few weeks after surgery, whereas one child with an unresectable tumor was treated prior to surgery. All patients had a ventricular-peritoneal CSF shunt connected to a subcutaneous reservoir. Total platinum and free carboplatin were measured. The mean AUC values for free carboplatin in CSF and plasma were 2.29±1.20 and 8.18±1.27 mg ml−1 min, respectively. The mean ratio of CSF AUC to plasma AUC was 0.28 (range, 0.17–0.46). Both plasma peak levels and AUC values showed limited interpatient variability. On the other hand, carboplatin levels in CSF showed substantial interpatient variability, with a〉5-fold difference in peak levels and a 3-fold difference in AUC values being recorded. The interpatient difference in CSF pharmacokinetics may have been related at least in part to the different anatomical alterations induced by the surgical procedures or by the presence of a large tumor mass. In the four evaluable patients exhibiting macroscopic residual tumor, we observed one complete remission (CR) and two partial remissions (PR) following two cycles that consisted of two doses of 600 mg/m2 carboplatin given on 2 consecutive days (total dose, 1200 mg/m2) and were separated by a l-month interval. These results may give some indication as to the optimal dose and schedule for carboplatin administration in the treatment of primitive neuroectodermic tumors (PNET).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686480
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  • 2
    Electronic Resource
    Electronic Resource
    Frequency measurements of far infrared laser lines by means of MIM point contact diodes (1994)
    Springer
    International journal of infrared and millimeter waves 15 (1994), S. 1347-1360 
    Details
    ISSN: 1572-9559
    Keywords: methanol ; Far Infrared laser ; frequency measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We present frequency measurements of 85 Far Infrared (FIR) laser lines ranging from 2 748 GHz to 421 GHz. We use the heterodyne technique of mixing FIR laser transitions and microwave radiation on MIM point contact diodes to determine the FIR frequencies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02096088
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  • 3
    Electronic Resource
    Electronic Resource
    Acoustooptic extension of the frequency tunability of CW CO2 lasers: New FIR lasers emissions from CH3OH and13CH3OH (1991)
    Springer
    International journal of infrared and millimeter waves 12 (1991), S. 449-471 
    Details
    ISSN: 1572-9559
    Keywords: waveguide CO2 lasers ; new FIR laser lines ; CH3OH ; 13CH3OH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have increased the frequency tunability of our CW waveguide CO2 lasers by means of an acoustooptic amplitude modulator, operating at the fixed frequency of 90 MHz. The up-shifted, or down-shifted, laser optical sideband can be generated independently by adjusting the orientation of the modulator. The efficiency is larger than 50%. The frequency tunability of the CO2 laser around each laser line is thus increased by 180 MHz. To demonstrate the possibilities of this method, a source composed of the above modulator and of a CW, 300 MHz tunable waveguide CO2 laser has been used for the search of new large offset FIR laser lines from optically pumped CH3OH and13CH3OH molecules. As a result 15 and 10 new large offset laser lines were discovered respectively. New assignments of some laser lines are also proposed. We have also measured the Stark effect, the offset, and the polarization of other already known lines. In particular a Stark effect frequency tuning of about 1 GHz is demonstrated for a laser line at 208.399 μm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01010879
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  • 4
    Electronic Resource
    Electronic Resource
    Measurements and assignments of new large offset CD3OH FIR laser lines (1991)
    Springer
    International journal of infrared and millimeter waves 12 (1991), S. 557-571 
    Details
    ISSN: 1572-9559
    Keywords: Waveguide CO2 lasers ; new FIR laser lines ; CD3OH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract By using an acoustooptic modulator we extend the 300 MHz tunability of a waveguide CO2 laser to 480 MHz. The CD3OH was optically pumped by the 10R(32), 10R(34), and 10R(36) CO2 laser lines, and 17 new FIR laser lines were discovered. The Stark effect on previously known FIR laser lines was investigated, and some tentative FIR laser lines assignments are suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01010375
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  • 5
    Electronic Resource
    Electronic Resource
    Experimental investigation of13CD3OH infrared transitions by means of optoacoustic spectroscopy (1992)
    Springer
    International journal of infrared and millimeter waves 13 (1992), S. 1801-1823 
    Details
    ISSN: 1572-9559
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A systematic investigation of13CD3OH infrared transitions around CO2 laser line emissions is performed by means of optoacoustic detection. Using a waveguide CO2 laser of 290 MHz tunability and, in some cases, an acoustooptic modulator to provide an extension of 180 MHz, 108 transitions are observed. Measurements of pump off-set and relative intensity have been performed. The data may be compared with those previously reported of high resolution Fourier Transform spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01010747
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  • 6
    Electronic Resource
    Electronic Resource
    A review of optically pumped far-infrared laser lines from methanol isotopes (1994)
    Springer
    International journal of infrared and millimeter waves 15 (1994), S. 1-44 
    Details
    ISSN: 1572-9559
    Keywords: FIR Laser Lines ; Methanol's Isotopes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The technique of optical pumping in polar molecules is the most efficient for Far-Infrared (FIR) laser generation, providing also a versatile and powerful tool for molecular spectroscopy in this spectral region. Methanol (CH3OH) and its isotopic varieties are the best media for optically pumped FIR laser, with over thousand lines observed, and the most widely used for investigations and applications. In this sense, it is important organize and make available catalogues of FIR laser lines as complete as possible. Since the last critical reviews of 1984 [1] on methanol and its isotopic varieties [2,3,4], over hundred papers have been published dealing with hundreds of new FIR laser lines. In 1992 a review of FIR laser lines from CH3OH was presented [5]. In this communication we extend this work to the other methanol isotopes, namely CH3OD, CD3OH, CD3OD,13CH3OH,13CD3OH,13CD3OD, CH3 18OH, CH2DOH, CHD2OH and CH2DOD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265874
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  • 7
    Electronic Resource
    Electronic Resource
    On the work mechanism of MIM point contact diodes (1992)
    Springer
    International journal of infrared and millimeter waves 13 (1992), S. 1099-1114 
    Details
    ISSN: 1572-9559
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have performed systematic measurements on a W-Ni MIM point contact diode at different IR, FIR, and IF frequencies in order to investigate the mechanisms responsible for the different response times observed in the diode operation. Our results led to the experimental confirmation of a second effect of thermal nature, besides tunnel effect, responsible for the diode operation. We measure the cutoff frequency of this second effect, which results in good agreement with our theoretical interpretation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01009053
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  • 8
    Electronic Resource
    Electronic Resource
    Assignments of methanol laser lines by frequency measurements and Fourier transform spectroscopy (1994)
    Springer
    International journal of infrared and millimeter waves 15 (1994), S. 619-633 
    Details
    ISSN: 1572-9559
    Keywords: methanol ; FIR laser ; frequency measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have measured the frequencies of four CH3OH far-infrared laser lines that were previously known only by wavelength measurement. Two of these lines turned out to be doublets, bringing the total number of measured lines to six. We can now confirm the assignments of five of them and definitely disprove the assignments proposed for the sixth. In particular we confirm the assignments for the four strong laser lines at 205 and 208 µm pumped by the 9-P(34) CO2 laser line. These lines share a common upper level in the first excited CO-stretch state, and terminate in the upper and lower levels of a hybrid state with J=5. Heterodyne frequency measurements and conventional microwave spectroscopy show that both lines are split into two components approximately 3.5 MHz apart. The origin of this further splitting is interpreted as a perturbed K-splitting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02096479
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  • 9
    Electronic Resource
    Electronic Resource
    New far infrared laser lines from 13CH2F2 and frequency measurements (1991)
    Springer
    Applied physics 52 (1991), S. 32-35 
    Details
    ISSN: 1432-0649
    Keywords: 42.55
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We report new FIR laser lines from 13CH2F2 molecules optically pumped by a waveguide CO2 laser. The increased tunability (300 MHz) with respect to a conventional CO2 laser allows the pumping of 13CH2F2 vibrational transitions of large offset. 34 new laser lines have been discovered, ranging from 113.1 μm to 491.4 μm in wavelength, thus increasing the number of known FIR laser lines from this important molecule to 99. For all the new lines and many (36) of those known previously, precise offset measurements through the transferred Lamb-dip technique were performed. The frequency of six new laser lines was also directly measured by heterodyne detection with known laser lines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405683
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  • 10
    Electronic Resource
    Electronic Resource
    IR and FIR spectroscopy of 13CD3OH around the 10P(22) and 10P(24) CO2 laser lines: New FIR laser emissions, frequency measurements and assignments (1992)
    Springer
    Applied physics 54 (1992), S. 24-28 
    Details
    ISSN: 1432-0649
    Keywords: 42.55
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract By using high resolution infrared Fourier transform data on 13CD3OH and the 10P(22) and 10P(24) lines of a waveguide CO2 laser to optically pump this methanol isotope, eight new FIR laser lines were observed. The frequencies of five laser lines were directly measured by heterodyne detection with already known laser lines. Particularly interesting are the lines pumped by the 10P(24) line, since a triade of emissions could be completely assigned.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331730
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