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Digitale Medien

Simultaneous noninvasive evaluation of gastric emptying and orocaecal transit times (1992)

Bergmann, J. F. ; Chassany, O. ; Guillausseau, P. J. ; [weitere]

Springer

European journal of clinical pharmacology 43 (1992), S. 121-124

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Details

ISSN: 1432-1041

Schlagwort(e): Cisapride ; Diabetic neuropathy ; gastric emptying ; orocaecal transit time ; gastroparesis ; controlled trial

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary The aim of the study was to use a novel combination of two methods for the simultaneous evaluation of two effects of oral cisapride in 10 diabetic patients with autonomic neuropathy; gastric emptying time was measured by following radio-opaque markers and orocaecal transit time by the sulphasalazine-sulphapridine method. The study was of double-blind, randomized, placebo-controlled, cross-over design. It was possible to evaluate the effect of a prokinetic drug on gastric emptying and orocaecal transit times using these two noninvasive techniques at the same time. Cisapride significantly reduced both the gastric emptying (1.2 h versus 2.1 h) and orocaecal tansit (5.9 h versus 7.7 h) times.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01740656

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