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  • 1
    Electronic Resource
    Electronic Resource
    AgNORs in colonic mucosal lesions (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02104.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Gastric epithelial atypia complicating hepatic arterial infusion chemotherapy (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 24 (1994), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Severe gastric lesions developed in five patients during hepatic arterial infusion chemotherapy employing 5-fluorouracil plus either leucovorin or mitomycin C. Ulceration with marked epithelial atypia was observed with striking structural distortion and cellular pleomorphism of the affected gastric mucosa. These features should be considered to be a complication of such treatment and should not be misinterpreted as malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1994.tb01294.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Signet-ring cell carcinoma of rectum (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 7 (1983), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1983.tb02224.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Proliferation and apoptosis in primary gastric B-cell non-Hodgkin's lymphoma (1997)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 30 (1997), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To elucidate the role of cell turnover in primary gastric B-cell non-Hodgkin's lymphomas we studied tissue samples of 72 patients—26 small cell (25 MALT lymphomas) and 46 large cell (31 MALT lymphomas). Proliferation indices and apoptotic indices were measured by Mib-1 expression and terminal deoxynucleotidyl-transferase (TdT)-mediated nick end labelling, respectively. Furthermore, expression of the apoptosis related gene-products bcl-2 and p53 was studied. Large cell lymphomas showed significantly higher proliferation indices (59.1% vs. 15.4%) and apoptotic indices (3.2% vs. 0.7%) than small cell lymphomas. Proliferation and apoptotic indices were positively correlated (r=0.371, P=0.03). Expression of the bcl-2 protein was significantly higher in the small cell lymphomas. Furthermore, cases with a high bcl-2 expression showed both a significantly decreased proliferation (P〈0.0001) and apoptotic index (P=0.0096) compared to bcl-2 negative cases. Expression of the mutant p53 protein was present in 8.0% of small cell and in 18.2% of large cell lymphomas. p53 positive cases showed significantly higher proliferation indices, but showed no correlation with apoptotic index. These data suggest that impaired apoptosis by bcl-2 may be more prominent than proliferation in the genesis of small cell lymphomas, whereas a high cell turnover characterizes large cell primary gastric lymphomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1997.d01-573.x
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  • 5
    Electronic Resource
    Electronic Resource
    Genetic heterogeneity in colonic carcinomas, adjacent adenomas and normal mucosa as detected with in situ hybridisation
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 77 (1994), S. 158 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(94)90270-4
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  • 6
    Electronic Resource
    Electronic Resource
    Specific detection of Helicobacter pylori and non–Helicobacter pylori flora in small- and large-cell primary gastric B-cell non-hodgkin's lymphoma (1997)
    Springer
    Annals of oncology 8 (1997), S. 33-36 
    Details
    ISSN: 1569-8041
    Keywords: bacterial flora ; Helicobacter pylori ; immunohisochemistry ; MALT ; primary gastric lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Primary gastric non-Hodgkin's lymphomas possibly develop in response to local infection by Helicobacter pylori (H. pylori). We investigated the presence of H. pylori and non–H. pylori flora histologically in small- and large-cell primary gastric lymphoma using a specific staining method. Materials and methods: Specimens of 52 cases of primary gastric lymphoma(17 small cell, 35 large cell) were stained with modified Giemsa (MG) and immunohistochemically using a polyclonal antibody against H. pylori (IHC). Results: Thirty-two cases (61.5%) (small cell 76% versus large cell 53%,P 〉 0.05) showed immunoreactivity for H. pylori in the mucosa surrounding the tumor. Remarkable, there waslocalization of H. pylori in the neck of the gastric glands in 3 cases.Non– H. pylori flora was seen in 35 cases (76.3%) (small cell53% versus large cell 74%,P 〉 0.05). In 20cases, this non– H. pylori flora was mixed with H. pylori. Five cases showed no bacterial flora at all. Conclusions: (1)Using immunohistochemistry, the prevalence of gastriclymphoma cases with H. pylori (61.5%) approximates that of H. pylori in the normal population. (2) No statistical difference was found between the occurrence of H. pylori and non–H. pyloribacterial flora in small- versus large-cell lymphoma. (3) Our results suggest that H. pylori may not be the only etiologic factor in primary gastric lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008205510594
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  • 7
    Electronic Resource
    Electronic Resource
    Specific detection of Helicobacter pylori and non–Helicobacter pylori flora in small- and large-cell primary gastric B-cell non-hodgkin's lymphoma (1997)
    Springer
    Annals of oncology 8 (1997), S. 33-36 
    Details
    ISSN: 1569-8041
    Keywords: bacterial flora ; Helicobacter pylori ; immunohisochemistry ; MALT ; primary gastric lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Primary gastric non-Hodgkin's lymphomas possibly develop inresponse to local infection by Helicobacter pylori (H. pylori). Weinvestigated the presence of H. pylori and non–H. pylori florahistologically in small- and large-cell primary gastric lymphoma using aspecific staining method. Materials and methods: Specimens of 52 cases of primary gastric lymphoma(17 small cell, 35 large cell) were stained with modified Giemsa (MG) andimmunohistochemically using a polyclonal antibody against H. pylori (IHC). Results: Thirty-two cases (61.5%) (small cell 76% versuslarge cell 53%,P 〉 0.05) showed immunoreactivityfor H. pylori in the mucosa surrounding the tumor. Remarkable, there waslocalization of H. pylori in the neck of the gastric glands in 3 cases.Non– H. pylori flora was seen in 35 cases (76.3%) (small cell53% versus large cell 74%,P 〉 0.05). In 20cases, this non– H. pylori flora was mixed with H. pylori. Five casesshowed no bacterial flora at all. Conclusions: (1)Using immunohistochemistry, the prevalence of gastriclymphoma cases with H. pylori (61.5%) approximates that of H. pylori in the normal population. (2) No statistical difference was foundbetween the occurrence of H. pylori and non–H. pyloribacterial flora in small- versus large-cell lymphoma. (3) Our resultssuggest that H. pylori may not be the only etiologic factor in primarygastric lymphoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008205510594
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  • 8
    Electronic Resource
    Electronic Resource
    CD44v6 is not a prognostic factor in primary breast cancer (1998)
    Springer
    Annals of oncology 9 (1998), S. 109-111 
    Details
    ISSN: 1569-8041
    Keywords: CD44v6 ; primary breast cancer ; prognostic factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: CD44 is an adhesion molecule and represents a highly variable family of isoforms. The isoform CD44v6 has been associated with metastasis formation and poor prognosis in animal models and human colon cancer. Results of studies in primary breast cancer are relatively small and contradictory. Patients and methods: The immunohistochemical expression of CD44v6 was studied in a series of 338 patients with primary breast tumours, uniformly staged and treated in a single center with a long median follow-up of 128 months. The prognostic significance of CD44v6 as well as the correlation with several clinicopathological features were analysed. Results: Two hundred nineteen of 338 (64.8%) of the breast cancers were CD44v6-positive (〉5% of tumour cells with positive staining). CD44v6 expression had no value for prognosticating disease-free or overall survival at this or any other cut-off point. Conclusion: CD44v6 expression is not a prognostic factor in primary breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008220917687
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Diagnostic value of ultrasound in children with recurrent abdominal pain (1990)
    Springer
    Pediatric radiology 20 (1990), S. 501-503 
    Details
    ISSN: 1432-1998
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the diagnostic value of ultrasound in children with recurrent abdominal pain and to estimate the clinical relevance of rare organic causes of abdominal pain in these patients, we prospectively examined 93 children aged between, 5.5 and 12 years by means of abdominal ultrasound. In 3 patients (3.2%) an anatomic abnormality was detected, which could not account for the abdominal pain. We conclude that many organic abnormalities, that could be diagnosed by ultrasound, are clinically irrelevant as a cause of recurrent abdominal pain in children and therefore ultrasound does not significantly contribute to the diagnosis. However, ultrasound can still play a role in the work-up of children with recurrent abdominal pain in avoiding unnecessary radiologic X-ray procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02011375
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Colonic epithelium reactive monoclonal antibodies (1989)
    Springer
    Histochemistry and cell biology 92 (1989), S. 397-406 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have produced a small library of colonic mucosa and colorectal carcinoma reactive monoclonal antibodies (MoAbs) by immunizations with extracts of human colon cancer tissue and a human colon cancer cell line. Hybridoma supernatants were tested on (normal and neoplastic) human tissues by immunoperoxidase methods to evaluate organ or tissue specificity. Initial biochemical characterization of the target antigens was performed by gelpermeation chromatography, Western blotting and competition assays. Based upon the immunoreactivity patterns and the characteristics of the antigen four groups of MoAbs could be distinguished. The first group concerns the antibodies PAR-LAM 3, 9 and 10. These antibodies react with an 87 kDa protein moiety in high molecular weight (2–5×106 Da) glycoproteins. In intestinal and colon mucosa these antibodies showed diffuse binding with goblet cells. In colon carcinoma decreased reactivity with these MoAbs was found. The second group consists of antibodies PARLAM 8, 12 and 13. These antibodies react with large (〉5×106 Da) glycoproteins, most likely with carbohydrate epitopes. By immunohistochemistry in normal colon mucosa the antibodies all show granular supranuclear reactivity with goblet cells. These antibodies show increased reactivity with colon adenomas and adenocarcinomas. A third group is formed by PARLAM 2, which also reacts with a large (〉5×106 Da) glycoprotein, showing a granular distribution in goblet cells. In colon carcinomas more extensive expression is found than in normal colonic mucosa. Finally, the fourth group consists of PARLAM 11, which also reacts with a large (〉5×106 Da) glycoprotein, located in the brush border of colonic columnar cells. These antibodies might be useful tools for the analysis of the expression of mucin related glycoproteins in normal, preneoplastic and neoplastic colon mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492497
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