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  • 1
    Electronic Resource
    Electronic Resource
    EXPERIMENTAL CHEMICAL PRODUCTION OF BRAIN TUMORS (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 381 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb50390.x
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  • 2
    Electronic Resource
    Electronic Resource
    Absence of carcinogenic effects of Estradiol mustard (NSC-112259) in rats (1976)
    Springer
    Journal of cancer research and clinical oncology 87 (1976), S. 197-198 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Östradiol-Lost (NSC-112259) wurde an weiblichen Sprague-Dawley-Ratten bei s.c. Applikation in Wochendosen von 10 bzw. 20 mg/kg bis zu Gesamtdosen (D max)von 500 bzw. 760 mg/kg auf carcinogene Wirkungen untersucht. Die Behandlung verkürzte die mittlere Lebenszeit erheblich. Carcinogene Wirkungen wurden nicht beobachtet, wohl aber toxische Schäden, die auf eine Dauer-Östrogen-Wirkung hindeuteten.
    Notes: Summary Estradiol mustard (NSC 112259) was subcutaneously injected to female Sprague-Dawley-rats in weekly doses of 10 and 20 mg/kg up to a total dose (D max) of 500 or 760 mg/kg respectively. Treatments reduced significantly the mean survival time. No carcinogenic properties were observed. Most of the estrogen mustard treated animals died from ovarian abscesses or peritonitis following pyometras. Toxic injuries were attributed to the chronical estrogenic stimulus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284377
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  • 3
    Electronic Resource
    Electronic Resource
    Carcinogenicity of acetoxymethyl-methyl-nitrosamine after subcutaneous, intravenous and intrarectal applications in rats (1978)
    Springer
    Journal of cancer research and clinical oncology 91 (1978), S. 217-221 
    Details
    ISSN: 1432-1335
    Keywords: Acetoxymethyl-methyl-nitrosamine ; Rats ; Different application methods ; Acetoxymethyl-methyl-nitrosamin ; Ratten ; verschiedene Applikationsmethoden
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vergleichend zu den bekannten carcinogenen Eigenschaften von Acetoxymethyl-Methyl-Nitrosamin (AMMN) nach oraler oder intraperitonealer Gabe wurde das Dimethylnitrosaminderivat in subkutaner, intravenöser und intrarectaler Applikation an männlichen Sprague-Dawley oder Wistar-Ratten geprüft. AMMN erwies sich als ein überwiegend lokal wirkendes Carcinogen. Zusätzlich ist ein zweiter Wirkungsmechanismus anzunehmen, da nach i.v. und s.c. Zufuhr systemische und carcinogene Eigenschaften auftraten. Lunge und Herz und weniger ausgeprägt die Niere und der Gehörgang erweisen sich als Trefferorgane der carcinogenen Wirkung entfernt vom Applikationsort.
    Notes: Summary In comparison to the known carcinogenic properties of Acetoxymethyl-Methyl-Nitrosamine (AMMN) after oral or intraperitoneal application the dimethylnitrosamine derivative was tested by subcutaneous, intravenous and intrarectal route in male Sprague-Dawley or Wistar rats. AMMN proved to be primarily a locally acting carcinogen. However, a second mode of action is indicated by systemic carcinogenic properties found after i.v. and s.c. applications. The lung and heart, and to a less extent the kidney and earduct were found as target organs of distant carcinogenic response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284028
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  • 4
    Electronic Resource
    Electronic Resource
    Chemotherapy studies in autochthonous rat tumors: Carcinomas of the forestomach (1979)
    Springer
    Journal of cancer research and clinical oncology 95 (1979), S. 39-42 
    Details
    ISSN: 1432-1335
    Keywords: Tumors of the forestomach ; Acetoxymethyl-methyl nitrosamine ; Experimental chemotherapy ; Bleomycin, methotrexate, 5-fluorouracil, 1,2-bis-(2-chloroethyl)-1-nitrosourea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Tumors of the forestomach were induced in male Sprague-Dawley rats by oral application of acetoxymethyl-methylnitrosamine (AMMN) in single weekly doses of 3.5 mg/kg body weight for 10 weeks. 100±5 days after the beginning of carcinogen treatment exploratory laparotomy was performed. One hundred animals in the same stage of tumor development were divided at random into one control group and four groups treated with cytostatics. Bleomycin (BLM), methotrexate (MTX), 5-fluorouracil (5FU), and 1,2-bis-(2-chloroethyl)-1-nitrosourea (BCNU) were tested in groups of 20 rats each. Only in animals receiving repeated doses of BLM a slight tumor response was observed but no increase in median survival times was seen. No therapeutic effects of the other drugs used were demonstrable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411107
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  • 5
    Electronic Resource
    Electronic Resource
    Diet and cancer (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 1-10 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusions Since unbalanced diets may increase the carcinogenic risk for certain organs, a balanced form of nutrition is to be recommended from the present point of view. It can also be recommended to avoid hyperalimentation, since this seems to have a positive effect on the cancer mortality risk; furthermore, ideal-weight individuals run a definitely lower risk of suffering a cardiac infarct than overweight individuals. Certain anticancer diets cannot be established. But the intake of juices and salads with a high vitamin C content can inhibit the formation of nitrosamines directly after the intake of food, because the nitrosation is prevented by nitrite interception. Negative influences of diets with a high fiber content are not known. Positive effects are discussed. Since it also prevents obstipation, it can well be recommended. Since dietary habits cannot shortly and easily be changed and changes in nutrition have a considerable impact on the personal quality of living, recommendations favoring certain diets should be given with all due caution. In our opinion the scientific basis for recommendations seems to be too small to justify very restrictive diets for cancer prevention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412892
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  • 6
    Electronic Resource
    Electronic Resource
    Experimental investigations on the influence upon the chemical carcinogenesis (1976)
    Springer
    Journal of cancer research and clinical oncology 86 (1976), S. 85-88 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach subcutaner Applikation von 0,5 mg 3,4-Benzpyren am 2. Lebenstag an Sprague-Dawley-Ratten entstanden bei 50% der Tiere nach 250±70 Tagen lokal an der Injektionsstelle Fibrosarkome. Die zusätzliche Behandlung mit immunostimulierenden Substanzen (BCG, Albumin, Vitamin A-Säure) bzw. immunodepressiv wirkenden Substanzen (Hydrocortison, Cyclophosphamid, Methotrexat), beginnend am 6. Tage nach der Geburt und durchgeführt bis zum Lebensende der Tiere, vermochte die Carcinogenese weder bezüglich der Häufigkeit der entstehenden Sarkome noch der Induktionszeit zu beeinflussen.
    Notes: Summary After subcutaneous application of 0.5 mg 3,4-benzopyrene (BP) to Sprague-Dawley-rats on the 2nd day of life, 50% of the animals developed local fibrosarcomas after 250±70 days. Additional treatment with immunostimulating (BCG, albumin, vitamin A-acid) or immunodepressive agents (hydrocortisone, cyclophosphamide, methotrexat) which was started 6 days after birth and maintained throughout life, did not influence carcinogenesis with respect to tumor incidences and induction periods of tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304937
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  • 7
    Electronic Resource
    Electronic Resource
    Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on yoshida sarcoma ascites cells implanted into the colon wall of rats (1979)
    Springer
    Journal of cancer research and clinical oncology 94 (1979), S. 63-67 
    Details
    ISSN: 1432-1335
    Keywords: Sprague-Dawley-Ratten ; Verimpfen von Yoshida-Sarkom-Zellen ; Colon descendens ; Cyclophosphamid ; BCNU ; Methyl-CCNU ; Sprague-Dawley rats ; Inoculation of Yoshida sarcoma cells ; Descending colon ; Cyclophosphamide ; BCNU ; Methyl-CCNU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Three thousand Yoshida sarcoma cells were inoculated into the wall of the descending colon of each of 120 male Sprague-Dawley rats. On day 8 after the tumor implantation, the animals were at random divided into four groups of 30 rats each. The effect of cyclophosphamide (70 mg/kg), BCNU (25 mg/kg), and methyl-CCNU (45 mg/kg) after single i.p. application was investigated. The Yoshida sarcoma transplanted into the colon is sensitive to all three chemotherapeutic drugs. At the doses given cyclophosphamide showed the best results. The two nitrosoureas had a comparable antitumor activity but methyl-CCNU showed a more distinct toxic effect. The introduction of this model for testing new cytostatics in animal experiments is discussed.
    Notes: Zusammenfassung Einhundertzwanzig männlichen Sprague-Dawley-Ratten wurden jeweils 3000 Zellen eines Yoshida-Sarkoms in die Wand des Colon descendens verimpft. Am 8. Tag nach der Tumorimplantation wurden die Tiere randomisiert in vier Versuchsgruppen von jeweils 30 Ratten aufgeteilt. Die Wirkung von Cyclophosphamid (70 mg/kg), BCNU (25 mg/kg) und Methyl-CCNU (45 mg/kg) bei einmaliger i.p. Gabe wurde untersucht. Das ins Colon transplantierte Yoshida-Sarkom ist gegeüber allen drei Chemotherapeutika sensibel. Bei den gewählten Dosierungen zeigte Cyclophosphamide die günstigsten Ergebnisse. Die beiden Nitrosoharnstoffe waren in ihrer Antitumoraktivität vergleichbar, während bei Methyl-CCNU die toxischen Wirkungen sich als ausgeprägter erwiesen. Der Einsatz des Modells im Rahmen der tierexperimentellen Prüfung neuer Cytostatika wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00405350
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  • 8
    Electronic Resource
    Electronic Resource
    Experimental investigations on the influence upon the chemical carcinogenesis (1976)
    Springer
    Journal of cancer research and clinical oncology 86 (1976), S. 89-94 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach zehnmaliger, monatlicher, subcutaner Injektion von 30 mg/kg 1,2-Dimethylhydrazin an Sprague-Dawley-Ratten, beginnend am 2. Lebenstag, entwickelten ∼90% der Tiere nach ∼330 Tagen Adenocarcinome des Dickdarms (72%), Plattenepithelcarcinome des Gehörgangs (17%). Adenosarkome der Niere (13%) sowie hepatocelluläre Carcinome (11%). Zusatzbehandlungen mit Immunodepressiva (Cyclophosphamid, Methotrexat, Hydrocortison), Immunostimulantien (BCG, Albumin, Vitamin A-Säure) oder Enzymstimulatoren (Luminal) änderten die Tumorausbeuten und Induktionszeiten nicht. Nach Applikation einer vegetarischen Diät waren die Ausbeuten an Nieren- und Leberkrebsen signifikant vermindert und die Induktionszeiten der Darm- und Gehörgangskrebse vergrößert.
    Notes: Summary After ten times monthly, subcutaneous, injections of 30mg/kg 1,2-dimethylhydrazine (DMH) to Sprague-Dawley-rats, malignant tumors were found in ∼90% of the animals after a mean induction period of ∼330 days. Injections were started on the 2nd day of life and maintained during 10 months. 72% of the tumors induced were formed in the colon, 17% were squamous cell carcinomas of the ear duct, adenosarcomas of the kidney and hepatocellular carcinomas were found in 13 and 11% of the animals, respectively. Additional treatment with immunodepressive (cyclophosphamide, methotrexat, hydrocortisone) and immunostimulating substances (BCG, albumin, vitamin A-acid) as well as an enzyme-stimulating agent (Luminal) did not alter incidences and induction periods of tumors. After application of a vegetarian diet, the rate of liver and kidney tumors was diminished significantly and induction periods of intestinal and ear duct tumors increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304938
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  • 9
    Electronic Resource
    Electronic Resource
    Zur carcinogenen Wirkung von N-Nitroso-Verbindungen (1978)
    Springer
    Journal of cancer research and clinical oncology 91 (1978), S. 317-322 
    Details
    ISSN: 1432-1335
    Keywords: Alkyl-Acetoxymethyl-Nitrosamines ; Carcinogenic action in SD rats ; Tumors of the forestomach ; Alkyl-Acetoxymethyl-Nitrosamine ; Carcinogene Wirkung bei SD-Ratten ; Tumoren des Vormagens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die homologe Reihe der Alkyl-Acetoxymethyl-Nitrosamine wurden auf ihre carcinogene Wirkung an SD Ratten getestet. Alle Verbindungen induzieren bei oraler Gabe innerhalb der gleichen Zeit Vormagentoumoren. Die benötigten Gesamtdosen sind dabei abhängig von der Länge der Alkyl-Kette und damit der Wasserlöslichkeit. Diese Ergebnisse werden diskutiert.
    Notes: Summary The homologons alkyl-acetoxymethyl-nitrosamines were tested for carcinogenicity in SD rats. All compounds were found to be carcinogenic and induced within the same time carcinomas of the forestomach. The total doses necessary for induction of tumors are related to the length of the alkyl chain and hence to the watersolubility. These results are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312293
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  • 10
    Electronic Resource
    Electronic Resource
    Chemotherapy studies in autochthonous rat tumors intestinal cancer (1978)
    Springer
    Journal of cancer research and clinical oncology 92 (1978), S. 105-117 
    Details
    ISSN: 1432-1335
    Keywords: Intestinal tumors ; Experimental carcinogenesis ; Chemical carcinogens ; Combined chemotherapy ; Darmtumoren ; Experimentelle Karzinogenese ; Chemische Karzinogene ; Kombinationschemotherapie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch drei chemische Carcinogene wurden Darmtumoren bei Ratten induziert. Nur bei durch 1,2-Dimethylhydrazin induzierten Tumoren konnte eine schwache Reaktion auf eine Kombinationschemotherapie mit Adriamycin, Methotrexat, 5-Fluorouracil und Cyclophosphamid beobachtet werden. Das gleiche Therapieschema versagte bei durch N-Methyl-N′-Nitro-N-Nitroso-Guanidin und durch Acetoxymethyl-Methyl-Nitrosamin induzierten Tumoren. Diese Ergebnisse und die Vergleichbarkeit der Chemotherapie autochthoner Tumoren mit experimentellen und klinischen Beobachtungen werden diskutiert.
    Notes: Summary Intestinal tumors in rats were induced by three different chemical carcinogens. Only tumors induced by 1,2-dimethylhydrazine responded slightly to combination chemotherapy of Adriamycin, Methotrexate, 5-Fluorouracil, and Cyclophosphamide. The same therapy failed in tumors induced by N-methyl-N′-nitro-N-nitroso-guanidine or acetoxymethyl-methyl-nitrosamine. These results and the comparability of chemotherapy in autochthonous tumors to experimental and clinical observations are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284097
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