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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 96 (1974), S. 1981-1982 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 61 (1939), S. 3605-3605 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 61 (1939), S. 2172-2175 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 63 (1941), S. 1336-1339 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 75 (1953), S. 5893-5896 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 86 (1993), S. 36-41 
    ISSN: 1432-0533
    Keywords: Alzheimer's disease ; β/A4 deposits ; Morphological types ; Spatial pattern ; Clustering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The spatial patterns of diffuse, primitive, classic (cored) and compact (burnt-out) subtypes of β/A4 deposits were studied in coronal sections of the frontal lobe and hippocampus, including the adjacent gyri, in nine cases of Alzheimer's disease (AD). If the more mature deposits were derived from the diffuse deposits then there should be a close association between their spatial patterns in a brain region. In the majority of tissues examined, all deposit subtypes occurred in clusters which varied in dimension from 200 to 6400 μm. In many tissues, the clusters appeared to be regularly spaced parallel to the pia or alveus. The mean dimension of the primitive deposit clusters was greater than those of the diffuse, classic and compact types. In about 60% of cortical tissues examined, the clusters of primitive and diffuse deposits were not in phase, i.e. they alternated along the cortical strip. Clusters of classic deposits appeared to be distributed independently of the diffuse deposit clusters. Cluster size of the primitive deposits was positively correlated with the density of the primitive deposits in a tissue but no such relationship could be detected for the diffuse deposits. This study suggested that there was a complex relationship between the clusters of the different subtypes of β/A4 deposits. If the diffuse deposits do give rise to the primitive and classic varieties then factors unrelated to the initial deposition of β/A4 in the form of diffuse plaques were important in the formation of the mature deposits.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 46 (1994), S. 209-213 
    ISSN: 1432-1041
    Keywords: Insomnia ; Temazepam ; elderly ; efficacy ; tolerance ; intermittent administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Temazepam, 7.5 mg was evaluated in the sleep laboratory in 8 elderly insomniacs, using a 14-night protocol (4 placebo-baseline nights, 7 drug nights, and 3 placebo-withdrawal nights). With short-term use temazepam was found to be effective, producing a significant improvement in total wake time from baseline (100 vs. 145 min). With continued drug administration, total wake time remained below baseline but not significantly so (125 vs. 145 min). During drug administration, there were no major CNS and behavioral adverse effects reported such as daytime sedation, memory impairment or hyperexcitability (daytime anxiety). Following drug withdrawal, there was no significant increase in wakefulness, i.e., no rebound insomnia (150 vs. 145 min). In summary, temazepam, 7.5 mg is effective in elderly subjects with short-term use and has a minimum of adverse effects. Use of hypnotic drugs is an adjunctive therapy which should be for a short-term period with subsequent short-term intermittent use as needed. Because of its low propensity for producing rebound insomnia, temazepam can be effectively used in this manner.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 83 (1985), S. 2447-2456 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The Ruff–MKW boiling point method is used to determine equilibrium vapor pressures greater than 660 Pa (5 Torr). Samples are vaporized from a Ruff cell, which has a capillary exit, in the presence of an inert gas. Viscosity coefficients and gaseous interdiffusion coefficients may be determined also. This is a second study of the method using Cd(l) and Zn(l) as samples. For the first study with CsCl(l), see J. Chem. Phys. 81, 915 (1984). Vapor pressure data are in good agreement with previous data and gave a third-law ΔsubH0(298) for Cd(s) of 111.95±0.42 kJ/mol and for Zn(s) of 130.65±0.48 kJ/mol. Analyses of the diffusion coefficients gave atomic diameters of 4.06×10−10 m for Cd and 3.46×10−10 m for Zn; these values are somewhat larger than previously measured values. In these experiments when the equilibrium vapor pressures were greater than 13 000 Pa (100 Torr), the need to consider heat transfer from the furnace to the vaporizing sample was noted, i.e., sample cooling occured due to rapid vaporization. Validity of the MKW analysis was found.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 115 (2001), S. 4689-4695 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Temperature- and density-dependent vibrational relaxation data for the v6 asymmetric stretch of W(CO)6 in supercritical fluoroform (trifluoromethane, CHF3) are presented and compared to a recent theory of solute vibrational relaxation. The theory, which uses thermodynamic and hydrodynamic conditions of the solvent as input parameters, shows very good agreement in reproducing the temperature- and density-dependent trends of the experimental data with a minimum of adjustable parameters. Once a small number of parameters are fixed by fitting the functional form of the density dependence, there are no adjustable parameters in the calculations of the temperature dependence. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 116 (2002), S. 3540-3553 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Infrared ps pump-probe experiments are presented for the P, Q, and R rotational branches of the asymmetric CO stretching mode of tungsten hexacarbonyl (1997 cm−1) in the collisionless gas phase. The pump-probe decays are tri-exponentials (140 ps, 1.3 ns, and 〉100 ns) in contrast to single exponential decays observed in supercritical fluids and liquid solvents. The 1.3 ns decay component is the vibrational energy relaxation (VER) time. The long component occurs following intramolecular VER into a distribution of low-frequency modes. After VER is complete, the R signal is 48%, the Q signal is 29%, and the P signal is −10% (absorption increase) compared to the t=0 signal. These long-lived signals result from an increase in the occupation numbers of low-frequency modes (internal heating) that causes a shift of the vibrational spectrum. The fastest decay is produced by spectral diffusion. The spectrally narrow pump pulse burns a hole in the inhomogeneous ground state spectrum and generates a narrow spectral population in the excited state (excited state peak). The inhomogeneity arises from the distribution of occupation numbers of the low-frequency modes that produces different combination band spectral shifts. Spectral diffusion is caused by the time evolution of the complex low-frequency thermal vibrational wave packet. Two possible models for the spectral diffusion are evaluated, one in which spectral diffusion reduces the pump-probe signal by hole filling and broadening of the excited state peak, and one in which the spectral diffusion only broadens the excited state peak. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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