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  • 1
    Electronic Resource
    Electronic Resource
    Deposition and Characterization of Polycrystalline Silicon Thin-Films by Reactive Thermal Chemical Vapour Deposition at 450°C (2003)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 93 (June 2003), p. 281-286 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/26/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.93.281.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Development of pollen-induced allergic rhinitis with early and late phase nasal blockage in guinea pigs (1998)
    Springer
    Inflammation research 47 (1998), S. 369-374 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Allergic rhinitis — Nasal blockage — Sneeze — Pollen — Airway resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: Development of nasal blockage and sneezing during repeated inhalation challenges with Japanese cedar pollens was evaluated in guinea pigs.¶Subjects: Male Hartley guinea pigs.¶Treatment: Guinea pigs were sensitized by intranasal instillation of cedar pollen extracts + Al(OH)3 2 times a day for 7 days. The animal was then forced to inhale the pollens for challenge, which was restrictively trapped in the upper airways, once a week.¶Methods: Change of specific airway resistance (sRaw), sneezing frequency, and titers of anaphylactic antibodies in the serum were measured after each of the 30 challenges.¶Results: At the first challenge, no obvious increase in sRaw was observed. However, the second and third challenges to the animals caused modest biphasic elevations of sRaw, with peaks at the first and the fourth to sixth hour. At the fourth to tenth challenges, marked elevations of sRaw were observed. However, with repetition of the inhalation challenge, the early and the late responses became almost indistinguishable because of partial overlapping as the responses expanded. All guinea pigs sneezed immediately after each pollen inhalation challenge. Apparent increases of both circulating γ1 and IgE antibodies were seen after the seventh challenge.¶Conclusions: These results indicate that the experimental allergic rhinitis established in the present study can be a valuable model for analyzing the pathogenesis of the disease and developing new therapeutic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050346
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  • 3
    Electronic Resource
    Electronic Resource
    Intraocular 6-hydroxydopamine prevents the persistent estrus induced by continuous light (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 125-127 
    Details
    ISSN: 1420-9071
    Keywords: 6-Hydroxydopamine ; intraocular administration ; continuous light ; persistent estrus ; female rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Following the intraocular injection of 6-hydroxydopamine, which can destroy the retinal dopaminergic neurons, female rats showed a normal estrous cycle in LD 12∶12 but not a persistent estrus in continuous light.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02005910
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  • 4
    Electronic Resource
    Electronic Resource
    Expulsion of the placenta from the uterus is the principal initiator for collagen degradation in mouse uterus (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 123-125 
    Details
    ISSN: 1420-9071
    Keywords: Placenta ; collagen degradation ; initiator ; uterus ; mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In unilaterally pregnant mice, collagen degradation in the non-pregnant uterine horn was not initiated by removal of the fetus only but by removal of both the fetus and placenta. The results indicate that expulsion of the placenta from the uterus is a principal factor in the initiation of the process of collagen degradation simultaneously in the whole uterus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01929354
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  • 5
    Electronic Resource
    Electronic Resource
    Socioeconomic and behavioural risk factors for mortality of individuals with IDDM in Japan: population-based case-control study (1996)
    Springer
    Diabetologia 39 (1996), S. 710-716 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes mellitus ; mortality ; case-control study ; clinical attendance ; risk factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this population-based, one-to-one matched-pair case-control study was to evaluate the factors concerning the markedly increased risk for dying among Japanese subjects with insulin-dependent diabetes mellitus (IDDM) from a social and behavioural perspective. The study was based on the population-based cohort of IDDM subjects in the Diabetes Epidemiology Research International Mortality Study. We studied 90 cases who died and 90 living control subjects, selected from the rest of the cohort, who were matched for sex, birth year, year of diagnosis and duration of diabetes. Socioeconomic and behavioural status were surveyed through a questionnaire. Conditional logistic regression analyses based on 55 respondent pairs revealed that the better educated patients (year of completing education: odds ratio =0.66) who kept the same physician (number of times a patient changed physician: odds ratio =2.77) and who attended a clinic specializing in diabetes (attendance at university hospital clinic: odds ratio =0.18) injecting insulin several times a day (number of injections, odds ratio =0.31) and more frequently attending the clinic (≥ 12 times per year, odds ratio =0.23) were at substantially lower risk of death. The results begin to profile the patients with the highest risk of dying who could be identified earlier and undergo intervention treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418543
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  • 6
    Electronic Resource
    Electronic Resource
    An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice (1990)
    Springer
    Diabetologia 33 (1990), S. 713-718 
    Details
    ISSN: 1432-0428
    Keywords: LZ-8 ; immunomodulator ; NOD mouse ; Type 1 (insulin-dependent) diabetes ; insulitis ; autoimmunity ; T cell subset
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ling Zhi-8 (LZ-8), a novel and recently discovered immunomodulatory protein having in vivo immunosuppressive activity, was tested for in vivo effect against Type 1 (insulin-dependent) diabetes mellitus in the non-obese diabetic mouse, the disease having immunologically mediated aetiology in this animal. LZ-8 had mitogenic activity in vitro towards spleen cells of the non-obese diabetic mice as previously shown towards those of DBA/2 mice. Intraperitoneal administration of LZ-8 twice weekly into the mice (10.3–12.6 mg/kg body weight) from 4 weeks of age prevented insulitis and an almost normal number of insulin producing cells were observed. Extreme insulitis and reduction of the number of insulin producing cells were observed in the pancreata of the untreated non-obese diabetic mouse. No cumulative incidence of diabetes mellitus was observed in the LZ-8 treated group, while cumulative incidences of 70% and 60% were observed in an untreated group followed up to 42 weeks of age when the incidence of diabetes was defined as a plasma glucose level of greater than 11 mmol/l and as a urine glucose level of greater than 2 +, respectively. T cell subset population analysis was performed to further investigate the action of LZ-8 on the non-obese diabetic mouse which revealed that LZ-8 treatment increased in L3T4+/Lyt-2+ ratio.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400340
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  • 7
    Electronic Resource
    Electronic Resource
    Socioeconomic and behavioural risk factors for mortality of individuals with IDDM in Japan: population-based case-control study (1996)
    Springer
    Diabetologia 39 (1996), S. 710-716 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Insulin-dependent diabetes mellitus ; mortality ; case-control study ; clinical attendance ; risk factor.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this population-based, one-to-one matched-pair case-control study was to evaluate the factors concerning the markedly increased risk for dying among Japanese subjects with insulin-dependent diabetes mellitus (IDDM) from a social and behavioural perspective. The study was based on the population-based cohort of IDDM subjects in the Diabetes Epidemiology Research International Mortality Study. We studied 90 cases who died and 90 living control subjects, selected from the rest of the cohort, who were matched for sex, birth year, year of diagnosis and duration of diabetes. Socioeconomic and behavioural status were surveyed through a questionnaire. Conditional logistic regression analyses based on 55 respondent pairs revealed that the better educated patients (year of completing education: odds ratio = 0.66) who kept the same physician (number of times a patient changed physician: odds ratio = 2.77) and who attended a clinic specializing in diabetes (attendance at university hospital clinic: odds ratio = 0.18) injecting insulin several times a day (number of injections, odds ratio = 0.31) and more frequently attending the clinic (≥ 12 times per year, odds ratio = 0.23) were at substantially lower risk of death. The results begin to profile the patients with the highest risk of dying who could be identified earlier and undergo intervention treatment. [Diabetologia (1996) 39: 710–716]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418543
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  • 8
    Electronic Resource
    Electronic Resource
    Geographic variation in mortality among individuals with youth-onset diabetes mellitus across the world (1997)
    Springer
    Diabetologia 40 (1997), S. 212-216 
    Details
    ISSN: 1432-0428
    Keywords: Keywords IDDM ; mortality ; incidence ; epidemiology ; life expectancy.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of this study was to evaluate the geographic variation in mortality among individuals with youth-onset insulin-dependent diabetes mellitus (IDDM) across the world. The study was based on the currently available IDDM incidence and mortality data. Mortality data for diabetes in the 0–24 year age group were obtained from World Health Organization (WHO) statistics. The mortality rates were adjusted for the frequency of occurrence of IDDM by dividing the mortality rates by the IDDM incidence rates which were obtained from the WHO DiaMond project. There was a more than 10-fold geographic variation in mortality between the developed countries and Eastern European populations. The areas with the highest mortality rates were located in Japan, Eastern Europe and Russia. The areas having the best outcome associated with IDDM were Northern Europe, Central Europe, and Canada. An ecological study demonstrated a relationship between the incidence-adjusted mortality (estimated case-fatality) with IDDM incidence itself (Spearman's correlation coefficient = –0.45) as well as infant mortality and life expectancy at birth. These data demonstrated the possibility of an enormous geographic variation in mortality of youth-onset diabetic patients even in developed countries. It is important to note that these excess deaths are potentially preventable. The ecological study also suggested that the mortality differences may be in part related to overall and diabetes related care. [Diabetologia (1997) 40: 212–216]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050665
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  • 9
    Electronic Resource
    Electronic Resource
    Development of full-length Trk B-immunoreactive structures in the prefrontal and visual cortices of the macaque monkey (2000)
    Springer
    Anatomy and embryology 201 (2000), S. 139-147 
    Details
    ISSN: 1432-0568
    Keywords: Key words Frontal cortex ; Visual cortex ; Primate ; BDNF ; NT4/5
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Distribution and morphological changes of cells containing the signal transducing neurotrophin receptor, full-length Trk B (fl-Trk B), were investigated in the prefrontal cortex (area FD) and the primary visual cortex (area OC) of the macaque monkey between embryonic day 140 and the adult stage. In area FD at the adult stage, fl-Trk B immunoreactivity was mainly observed in the pyramidal cells in layers II/III, V and VI. Small numbers of granule cells in layer IV were immunopositive. Bipolar and multipolar cells in layer II were rarely immunoreactive. At embryonic day 140, the number of fl-Trk B immunoreactive pyramidal cell was high, and gradually decreased until the adult stage. In layer IV, the number of fl-Trk B-ir cells was also high at embryonic day 140, and decreased remarkably from postnatal day 7 to the adult stage. On the other hand, in area OC at the adult stage, cells in layers II/III, IV, V and VI were fl-Trk B immunopositive. From embryonic day 140 until adulthood, the cells in layer IVc were fl-Trk B immunoreactive. The strongest fl-Trk B immunoreactivity in areas FD and OC occurred at postnatal month 6, coinciding with the time of the synapse overproduction. These findings suggest that ligands of fl-Trk B, such as BDNF and NT4/5 may be involved in the development and maintenance of the monkey cerebral cortices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008234
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  • 10
    Electronic Resource
    Electronic Resource
    Role of protein in larval swimming and metamorphosis of Bugula neritina (Bryozoa: Cheilostomatida) (1999)
    Springer
    Marine biology 133 (1999), S. 701-707 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Larvae of the marine cheilostomatid bryozoan Bugula neritina (L.) were prevented from settling for 1, 4 and 8 h by mechanical agitation, following which settlement and metamorphosis success were examined. Settlement rates were significantly affected by swimming time, which decreased from 100% after 2 h to 93.7 ± 4.3% after 8 h. Similarly, metamorphosis to the feeding ancestrula was significantly impaired following a swimming time of 8 h, declining from 93.7 ± 4.3% after 1 h to 65.9 ± 7.0% after 8 h. The resultant colonies grew well for the first 3 wk, following which time, growth patterns became erratic. Growth rate was in all cases highly variable, and did not correlate with enforced swimming times. Larval protein composition was examined after 1, 4 and 8 h swimming time, and post-larval composition 1, 2, 5, 24 and 48 h after settlement using sodium-dodecyl-sulphate polyacrylamide-gel electrophoresis (SDS-PAGE). Individual protein content was measured using a densitometer. Larvae did not consume protein during swimming, however a protein measuring 170 kdaltons was consumed during metamorphosis. These results are discussed in the context of larval settlement and energetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270050511
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