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Digitale Medien

Experimental germanium myopathy (1991)

Higuchi, I. ; Takahashi, K. ; Nakahara, K. ; [weitere]

Springer

Acta neuropathologica 82 (1991), S. 55-59

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Details

ISSN: 1432-0533

Schlagwort(e): Germanium intoxication ; Mitochondrial myopathy ; Ragged-red fiber ; Autophagic vacuole

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The long-term administration of germanium dioxide (GeO2) to rats produced Ge myopathy characterized by the formation of ragged-red fibers. The earliest pathological changes in experimental Ge myopathy were a decrease in cytochrome c oxidase activity and accumulation of high electron-dense materials in mitochondria. These findings suggest that a mitochondrial dysfunction may be most important in the genesis of experimental Ge myopathy, which could be a useful animal model for the investigation of and therapeutic trials for human mitochondrial myopathies.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00310923

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