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  • Electronic Resource  (79)
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  • Electronic Resource  (79)
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  • 1
    Electronic Resource
    Electronic Resource
    Cryotherapy for lentigo maligna — is clinical acumen combined with a single punch biopsy good enough for staging? (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 7 (1996), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim We aimed to clarity the effectivenes of our staging of LM over a I-year period.Background Cryosurgery has become accepted as a simple and effective treatment for lentigo maligna (LM) but not necessarily lentigo maligna melanoma (LMM). Pigmented epithelial cells are extremely sensitive to cold injury. If adequate freezing is delivered to the proper depth into the dermal appendages, LM should be eradicated. However, if the initial staging does not detect invasion the lesion may be inadequately treated.Methods Over 1 year prospectively. all patients presenting with LM(n= 12) wore stayed clinically by experienced dermatologists and by a single punch biopsy. This was then checked by complete excision of the lesion.Results In 9 patients the clinical and punch biopsy diagnosis was confirmed after excision. Two melanomas were missed clinically but detected on punch biopsy. In one patient the punch biopsy described a “LM with probable invasion elsewhere in the lesion”. Surgical excision yielded a melanoma, 0.8 mm thick. Clark's level 4. In a second patient, punch biopsy diagnosed superficial spreading melanoma (-SSM) in situ, confirmed on excision.Conclusions We therefore feel that clinical diagnosis combined with a single punch biopsy will diagnose invasion when present. We emphasise that cryotherapy should not be performed without punch biopsy confirmation of the clinical diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1996.tb00554.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Marie Unna hypotrichosis: an autosomal dominant hair disorder (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the European Academy of Dermatology and Venereology 7 (1996), S. 0 
    Details
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hereditary hypotrichosis of Marie Unna type is a rare distinctive syndrome of hair loss which is inherited with an autosomal dominant gene. We report a family with more than half affected individuals in 4 subsequent generations which supports the very strong autosomal dominant pattern of inheritance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-3083.1996.tb00584.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Matting of scalp hair during shampooing—a new look (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 15 (1990), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We present a new case of irreversible hair matting, a rare, but important and alarming, acquired hair disorder. This case was investigated to test the causal hypothesis proposed in 1984. At the same time four other specimens of matted hair from patients and tangles from normal individuals were also examined. Light and electron microscopy showed dramatic permanent twisting and bending of the hairs through 180°. There was marked variation in the fibre width of hairs from matted samples, with some longitudinally split along a considerable length. This bending and entanglement of hairs of varying widths (felting) seemed to be the main reason for the hairs becoming so dramatically knotted together in four of the cases. In only one case was there any evidence of a viscous fluid binding the hair together. This finding suggests that there may be two different mechanisms involved in hair matting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1990.tb02052.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Is keratosis pilaris another androgen-dependent dermatosis? (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 13 (1988), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1988.tb00688.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Congenital and hereditary nail dystrophies—an embryological approach to classification (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 13 (1988), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In many congenital and hereditary ectodermal syndromes, nail changes can often provide the earliest definitive and consistent signs by which the condition may be identified.In the dermatological, paediatric and genetic literature the nail signs are usually described on purely morphological grounds with little attention being paid to the embryological defect or defects underlying such changes. Consequently, any secondary changes produced by trauma to the nails may be confused with, and included in, the primary‘diagnostic’features.We propose a pathophysiological approach to the nail changes in congenital and inherited conditions: these will be classified as defects in the nail matrix, defects in the nail field or bed, and combined disorders originating from ectodermal and mesodermal tissues (Table 1). This is a simplistic classification and many disorders will result from a combination of these defects. Each of the defects will be illustrated by genodermatoses in which the knowledge of normal nail embryology and intra-uterine development aids description and diagnosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1988.tb01960.x
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Pseudo-mycotic nail dystrophy and vitiligo (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 13 (1988), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Vitiligo is often associated with alopecia areata and is believed to be an autoimmune disease. Although nail changes arc recognized to occur in association with alopecia areata, they have only been reported in cases of vitiligo and concurrent alopecia areata.1,2 We report on two cases of the rare pseudo-mycotic variant of nail dystrophyl3 in vitiligo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1988.tb00671.x
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    An epidemiological profile of in-patient workload in dermatology (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 17 (1992), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Trends in admission rates, patterns of readmission, lengths of stay and clinical caseload for in-patient dermatology from 1976 to 1985 are described using data from the Oxford record-linkage study. Age-specific admission rates were considerably higher in people aged 50 years and over than in younger people. Admission rates declined over time in most age-sex groups below the age of 70 years, but increased over time for the over 70s. In dermatology, unlike most other specialties, the length of patients' stay did not decrease substantially over the 10 years. In-patient workload consisted predominantly of leg ulcers, psoriasis, and eczema. This did not change appreciably over time. New out-patients at dermatology clinics rose by 41% from 1976 to 1985, and all out-patient visits rose by 20% during the 10-year period. Because the profile of in-patient workload changed relatively little over time, we speculate that the impact of innovations in dermatological practice has been much greater in the ambulatory setting than in the management of those patients requiring prolonged in-patient care. Future routine measures of workload in dermatology should include demographic and clinical data on out-patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1992.tb00248.x
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Digital arteriovenous malformation (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03691.x
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Onychopapilloma is not a distinct clinicopathological entity (2002)
    Oxford, UK : Blackwell Science, Ltd
    British journal of dermatology 146 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.46162.x
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Darier's disease: an immunohistochemical study using monoclonal antibodies to human cytokeratins (1988)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 118 (1988), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The pathogenesis of Darier's disease was investigated by immunohistochemical staining of skin biopsies from involved and uninvolved skin in 14 patients, using monoclonal antibodies specific for keratins expressed in simple epithelia, stratified squamous epithelia and during skin specific differentiation as well as keratins expressed in mucosa and some benign epidermal hyperproliferative states.Uninvolved perilesional skin from Darier's patients showed a normal profile of keratin expression, whereas in lesional skin there was apparent delay in the expression of the suprabasal skin specific keratins. Suprabasal keratins were not detected in basal cells, thus there was no true premature keratinization. The presence of hyperproliferative keratins was restricted to suprabasal cells in lesional skin. Four patients were receiving treatment with ctretinate at the time of biopsy, but results in these patients did not differ from patients using topical treatments. Etretinate did not influence the profile of keratin expression in uninvolved or involved skin. The expression of type VII collagen was examined and was normal throughout uninvolved and iL-sHiiitil skin in Darier's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1988.tb02563.x
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