ISSN:
1432-1912
Keywords:
2-Aminotetralins
;
N-0434
;
N-0437
;
3H-Spiperone
;
D2 Receptor
;
Dopamine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The affinity of a series of N,N-disubstituted 2-aminotetralins for the rat striatal D2 dopamine receptor labelled by [3H]spiperone has been determined. Displacement data for the more potent 2-aminotetralins were better described by a model where the compounds competed for [3H]spiperone at two sites. The high affinity component accounted for approximately 80% of the total sites. Displacement curves for all 2-aminotetralins were shifted to the right by 100 μM guanosine-5′-triphosphate; a result attributable to the redistribution of 13–47% of the sites to a low affinity form. These data are consistent with the N,N-disubstituted 2-aminotetralins being agonists at the D2 dopamine receptor. In particular, the affinities of the 5-hydroxy-2-aminotetralins were as high as those of traditional dopamine agonists.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00169304
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