ISSN:
0268-2605
Keywords:
adduct
;
carboxylate
;
Ceratocystis ulmi
;
Dutch elm disease
;
far-infrared spectroscopy
;
fungicide
;
Mossbauer spectroscopy
;
organotins
;
QSAR
;
thiazolidin-4-ones
;
triphenyltin
;
Chemistry
;
Industrial Chemistry and Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
In the interest of developing a more effective fungicide to combat Dutch elm disease, our laboratories have synthesized several triphenyltin carboxylates and some 1:1 addition compounds of triphenyltin chloride using 2,3-disubstituted thiazolidin-4-ones as the ligand and screened them in vitro against Ceratocystis ulmi, the causative agent of Dutch elm disease, using a shake culture method. Elemental analyses and spectroscopic data indicate that the structures of the carboxy- lates in the solid state are monomeric with a tetrahedral tin atom with the exception of the furan-2-carboxylic acid derivative, which was found to be polymeric. The triphenyltin chloride adducts are trigonal-bipyramidal with the three phenyl groups in the equatorial plane. Far-infrared data indicate that the three phenyl groups are not co-planar. Screening results for both series of organotins indicate that these two classes of compounds are effective inhibitors of Ceratocystis ulmi, with the adducts having a higher activity. The furan-2-carboxylic acid derivative has a markedly decreased activity compared with the other carboxylates and this is attributed to its polymeric structure. © 1998 John Wiley & Sons, Ltd.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
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