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  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 2 (1963), S. 1079-1084 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 26 (1954), S. 1543-1546 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 137 (1972), S. 1-29 
    ISSN: 1432-0568
    Keywords: Corticotropin-Releasing Factor ; Median eminence ; Rat ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der Zona externa infundibuli der normalen Ratte kommen geringe Mengen „Gomori-positiver” Granula vor. Nach bilateraler Adrenalektomie erfolgt eine Vermehrung der Granula, die sich durch Gabe von Hydrocortison einschränken oder verhindern läßt. Dieser Befund hat zu der Annahme geführt, daß die Granula das morphologische Äquivalent des Corticotropin-releasing factor (CRF) darstellen. Morphometrische Untersuchungen an 160 weiblichen Wistarratten zeigen, daß die Menge der nach bilateraler Adrenalektomie in der Zona externa infundibuli nachweisbaren „Gomori-positive” Granula von der postoperative Überlebensdauer abhängt. Die Granulamenge nimmt zunächst bis zum 14. Tag p.o. zu und fällt dann wieder ab. Substitution bilateral adrenalektomierter Ratten mit Hydrocortisonacetat-Kristallsuspension bewirkt eine dosisabhängige Verminderung der Granulamenge, wenn die Behandlung am Operationstag begonnen wird. Applikation von Hydrocortisonacetat-Kristallsuspension vom 14.–21. Tag p.o. führt dagegen zu einer gesteigerten Granulavermehrung. Auch bei stärkster Vermehrung sind die Granula stets nur im Infundibulum und nicht in anderen Bereichen des Hypothalamus nachweisbar. Sie besitzen bei bilateral adrenalektomierten Tieren ein charakteristisches Verteilungsmuster mit besonders hohen Konzentrationen in den paramedianen Abschnitten des rostralen Infundibulumdrittels. Aus der Art und Weise ihrer Verteilung ist zu vermuten, daß die Granula 2 Nervenfaserzügen angehören und ein Neurosekret darstellen. Nach den vorliegenden Untersuchungen besteht zwischen dem Verhalten der „Gomori-positiven” Granula in der Zona externa infundibuli und dem aus pharmakologischen Untersuchungen bekannten Verhalten des Corticotropin-releasing factor eine weitgehende Parallelität. Sie legt nahe, die Menge der Granula als Parameter der CRF-Aktivität zu verwenden.
    Notes: Summary In the zona externa infundibuli (outer layer of the median eminence) of the normal rat a minute number of “Gomori-positive” granules can be detected. Following bilateral adrenalectomy their number increases. This augmentation can be restricted or inhibited by administration of hydrocortisone, a finding, which has led to the assumption that the granules are the morphological equivalent of the corticotropin-releasing factor (CRF). Morphometrical studies on 160 female Wistar rats show that following bilateral adrenalectomy the quantity of “Gomori-positive” granules is dependent on the length of the post-operative survival period. Up to the 14th day p.o. the quantity of granules increases; from then on it diminishes. Substitution of bilaterally adrenalectomized rats with hydrocortisone acetate crystal suspension results in a dose-dependent decrease in the quantity of granules if treatment is begun on the day of operation. In contrast, administration of hydrocortisone acetate crystal suspension from the 14th to the 21st day p.o. results in increased augmentation of the granules. Even when maximum augmentation of the granules is reached, they are invariably found only in the infundibulum and not in other regions of the hypothalamus. In animals that have been subjected to bilateral adrenalectomy, the granules show a characteristic pattern of distribution, with particularly high concentrations in the paramedian parts of the rostral third of the infundibulum. The manner in which the granules are distributed suggests that they are a neurosecretory substance localized in two fibre tracts. The present study points to a close parallelism between the behaviour of the “Gomori-positive” granules in the zona externa infundibuli and that of the corticotropin-releasing factor as revealed by pharmacological investigations. It would seem that the quantity of granules can be used as a parameter of CRF activity.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0568
    Keywords: CRF-granules ; Sodium chloride ; Adrenalectomy ; Rat ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bilaterally adrenalectomized female SPF Wistar rats were given tap water containing various concentrations of sodium chloride to drink ad lib. After a survival period of 14 days the animals were killed by perfusion-fixation. Their brains were removed, fixed in pieric acid formalin solution and embedded in Paraplast. Serial sections of median eminence and hypophysial posterior lobe were cut and stained with crotonaldehyde-fuchsine. In the stained sections the amount of CRF-granules visible in the external zone of the median eminence, and the amount of “classical” neurosecretory material (NSM) occuring in the internal zone of the median eminence and in the posterior lobe of the hypophysis were estimated. After administration of drinking solutions to which 0%–1% sodium chloride were added, the amount of CRF-granules increased with increasing NaCl uptake, whereas the amount of “classical” NSM was not changed. Application of tap water containing 2% NaCl led to a marked decrease in the amount of “classical” NSM but did only slightly impair the amount of CRF-granules. From the findings it is concluded that 1. following bilateral adrenalectomy administration of sodium chloride inhibits the secretion of CRF-granules; 2. CRF-granules and “classical” NSM, although histochemical identical, have different functional significances; 3. the mechanisms regulating the secretion of CRF-granules are different from those controlling the release of “classical” NSM.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0568
    Keywords: Corticotropin releasing factor ; Neurosecretion ; Hypophysis ; X-irradiation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 195 female Wistar rats the influence of adrenalectomy, total body X-irradiation and dexamethasone treatment on the amount of CRF-granules in the external zone of the median eminence and “classical” neurosecretory material (NSM) in the internal zone of the median and in the posterior lobe of the hypophysis has been studied. In the normal rat only very few CRF-granules occur. 15 days after adrenalectomy increased amounts of CRF-granules but normal amounts of “classical” NSM are found. X-irradiation leads to a slight diminishment of “classical” NSM in normal rats. In adrenalectomized animals X-irradiation causes no changes in the amount of “classical” NSM but a marked decrease in the amount of CRF-granules. Application of dexamethasone from the 15th to 18th day after adrenalectomy enhances the augmentation of CRF-granules in irradiated and non-irradiated rats but does not influence the amount of “classical” NSM. The findings show that no correlation exists between the quantitative changes of CRF-granules and “classical” NSM under the experimental conditions used. Therefore it is to be assumed that the release of the two substances is regulated by different control mechanisms and that the substances have a different functional significance. The observations do not exclude the possibility that CRF-granules and “classical” NSM are biochemically identical.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0568
    Keywords: Neurosecretion ; Adrenalectomy ; Diabetes insipidus ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of adrenalectomy on the amount of “Gomori-positive” neurosecretory material in the outer layer of the median eminence and in the supraoptico-hypophysial system was studied in normal Long-Evans rats and in Long-Evans rats heterozygous and homozygous for hypothalamic diabetes insipidus. In all non-adrenalectomized rats very few “Gomori-positive” granules were found in the outer median eminence layer. After adrenalectomy the amount of the granules increased markedly in normal Long-Evans rats and only slightly in Long-Evans rats heterozygous for diabetes insipidus. However, no augmentation of the granules occurred in homozygous diabetes insipidus rats. The amount of “Gomori-positive” substances demonstrable in the supraoptic and paraventricular nuclei, in the inner layer of the median eminence, and in the neural lobe of the hypophysis was less in rats heterozygous for diabetes insipidus than in normal Long-Evans rats and the smallest in homozygous diabetes insipidus rats. No differences in the amounts of the substances were observed between adrenalectomized and non-adrenalectomized animals. The findings suggest that the “Gomori-positive” granules occurring in the outer layer of the median eminence of adrenalectomized rats are of similar origin as those of the supraoptico-hypophysial system and represent a vasopressin-neurophysin-complex. The results support the concept that vasopressin is involved in the regulation of ACTH release.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0568
    Keywords: Pantothenic acid deficiency ; Corticotropin-releasing factor ; Corticoids ; Histologie ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the outer layer of the rat median eminence “Gomori-positive” granules occur which are assumed to be the morphological correlate of the corticotropin-releasing factor (CRF). The present study was carried out in order to establish whether the amount of these CRF-granules is influenced by a pantothenic acid (PA)-deficiency, which is known to result in an inhibition of corticosteroid production. Female SPF Wistar rats were used. PA-deficiency was induced by PA-free nutrition and/or administration of the PA-antagonist Ω-methyl-PA. Corresponding experimental groups were given either tap water or a solution of 1% NaCl and 5% glucose in tap water to drink. In rats fed with a diet free of PA and in addition treated with Ω-methyl-PA a severe disturbance of the corticoid balance developed within 6 weeks. The corticosterone production was depressed to about 11–16% of the control values. The adrenal cortex showed necrotic changes which either involved the whole parenchyma or were confined to the inner zones. In those animals in which a subcapsular region, in its extent corresponding to the zona glomerulosa, remained intact, an augmentation of the CRF-granules was observed. In those animals, however, in which the whole adrenal cortex was damaged, the amount of CRF-granules did not increase. Administration of the 1% NaCl containing drinking fluid did not influence the augmentation of the CRF granules, but had a protective effect on the development of necrotic changes in the zona glomerulosa of the adrenal cortex. The findings show that a functional relationship exists between the inner zones of the adrenal cortex and the CRF-granules in the median eminence.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of microbiology 100 (1974), S. 243-252 
    ISSN: 1432-072X
    Keywords: Saccharomyces cerevisiae ; Carbon Monoxide Trace-Measurement ; 14C-Glucose ; CO Production ; Atmospheric Cycle of Trace Gases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Zusammenfassung 1. Mit einer empfindlichen Analysenmethode, die auf die Reaktion CO+HgO→CO2+Hg basiert und den CO-Gehalt auf Grund der Absorption des freigesetzten Hg bei 2537 Å ermittelt, wurden im Gasraum über wachsenden Kulturen von Saccharomyces cerevisiae, S. oviformis, Escherichia coli, Aerobacter aerogenes, Pseudomonas spec. und Lactobacillus brevis 0.4–2.6 ppm CO nachgewiesen. Bei Lactobacillus arabinosus, Bacillus cereus var. mycoides und Aspergillus niger war eine CO-Bildung nicht meßbar. 2. Bei S. cerevisiae war die CO-Bildung bei Konzentrationen von 10–50 g Glucose pro Liter Medium am größten. Außerdem wurde die CO-Bildung proportional zum anfänglichen Sauerstoffgehalt im Gasraum über den Kulturen gefördert. 3. Mit 14C-markierter Glucose wurde nachgewiesen, daß CO aus Glucose entsteht. 4. Die CO-Bildung der untersuchten Mikroorganismen ist so gering, daß sie keine Bedeutung für den Kreislauf dieses Spurengases in der Atmosphäre hat.
    Notes: Summary 1. Growing cultures of Saccharomyces cerevisiae, S. oviformis, Escherichia coli, Aerobacter aerogenes, Pseudomonas spec. and Lactobacillus brevis produce trace amounts of CO (0.4–2.6 ppm) that can be detected in the gas space above the cultures using a sensitive analytical method based on the reaction CO+HgO→CO2+Hg. The liberated Hg is quantitatively measured by atomic absorption at 2537 Å. No CO could be detected above cultures of Lactobacillus arabinosus, Bacillus cereus var. mycoides and Aspergillus niger. 2. The maximum CO production by Saccharomyces was obtained with concentrations of 10–50 g glucose per liter medium. The amount of CO formed increased with the oxygen concentration in the gas space above the cultures. 3. Using 14C-glucose it was shown that S. cerevisiae forms CO from glucose. 4. The formation of CO by the microorganisms investigated is very small. The ratio of CO/CO2 produced is much smaller than in environmental air. Therefore it can be concluded that the production of CO by these microorganisms has probably no significance for the atmospheric cycle of this trace gas.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1090-6487
    Keywords: 52.50.Jm ; 52.25.Jm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A new approach for investigation of the generation of fast ions and hot electrons inside the same plasma volume in laser-produced plasmas is proposed. It is based on the spectroscopic observation of line radiation from singly and doubly excited levels with simultaneous high spectral and spatial resolution. The experimental results demonstrate the observation of fast ions from highly charged target material inside the plasma volume and suggest that the generally accepted scaling relations are seriously invalid under certain conditions. Even at rather modest intensities ions with energies of several MeV are observed.
    Type of Medium: Electronic Resource
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