ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Oligotripeptides Z-(Gly-Pro-Pro)n-OMe (n = 1,2,…,8), Z-Gly-Pro_Pro-Gly-Pro-Gly-OMe, Z-Gly-Pro-Pro-Gly-Pro-Gly-Gly-Pro-Pro-OMe, Z-Gly-Pro-Pro-(Gly-Pro-Gly)2-Gly-Pro-Pro-OMe, and Z-(Gly-Pro-Ala)n-OMe (n = 1,2,…,4) were synthesized step-by-step and then studied by means of x-ray diffraction, ir spectroscopy, the kinetics of hydrogen-deuterium exchange of peptide groups, and circular dichroism,. Different stages in the formation of a triple helix in Z-(Gly-Pro-Pro)n-OMe were revealed during the chain elongation. In the solid state, at the first stage a conformation of the polyproline II-type is formed in the tripeptide and in the second stage a triple helical complex appears in the hexapeptide. Interpeptide hydrogen bonds in this complex are still of low order. At further stages an ordered set of interpeptide hydrogen bonds is gradually formed. It is shown that the degree of order of interpeptide H bonds depends on the length of the molecular chain, the amino acid composition, and residue sequence in the triplets.
Additional Material:
14 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1978.360170509
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