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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 78 (1956), S. 2637-2641 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : The use of antibiotic prophylaxis prior to percutaneous endoscopic gastrostomy insertion has been encouraged following development of guidelines by a number of professional societies within the past few years. However, not all evidence supports routine prophylaxis, particularly in patients with ‘benign’ disease indications for percutaneous endoscopic gastrostomy insertion.Aim : To identify whether prophylactic antibiotic usage is beneficial in patients undergoing percutaneous endoscopic gastrostomy insertion without malignant disease.Methods : Adult patients without malignant disease who were referred for percutaneous endoscopic gastrostomy insertion at our unit were assessed for participation in this prospective, double-blind, randomized controlled study. Patients were randomized to receive either placebo or 2.2 g co-amoxiclav (or 2 g cefotaxime if penicillin-allergic) at time of percutaneous endoscopic gastrostomy insertion. Clinical endpoints studies were percutaneous endoscopic gastrostomy site or systemic infection and death within 7 days of percutaneous endoscopic gastrostomy insertion.Results : Ninety-nine patients completed the study (51 antibiotics, 48 placebo). Outcomes in the antibiotic and placebo groups respectively were: percutaneous endoscopic gastrostomy site infection, 11% vs. 47% (P 〈 0.01); systemic infection, 16% vs. 38% (P 〈 0.05); and death, 8% vs. 15% (P = 0.5).Conclusions : Antibiotic prophylaxis prior to percutaneous endoscopic gastrostomy insertion reduces both percutaneous endoscopic gastrostomy site and systemic infections in patients without malignant disease.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 16 (1944), S. 182-184 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of the European Academy of Dermatology and Venereology 19 (2005), S. 0 
    ISSN: 1468-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Biological research suggests that vascular changes may play a major role in rosacea pathogenesis. Chrysanthellum indicum is a plant-based extract containing a unique combination of phenylpropenoic acids, flavonoids and saponosids, and has a well-documented effect on vascular wall permeability and increase of the mechanical resistance of capillaries.Objective  To determine the efficacy and safety of a cream containing 1%C. indicum extract with vitamin P properties in the treatment of rosacea.Methods  This study included 246 patients diagnosed clinically as having moderate rosacea. Patients were randomly allocated to C. indicum extract-based cream (n = 125) and placebo (n = 121) groups. Patients were advised to apply the products on their face twice a day for a 12-week period. The patients were examined at the end of each 4-week period. Severity of erythema (graded by reference to six photographs), surface of erythema and rosacea overall severity scores were recorded at each visit on days 0, 28, 56 and 84. Investigators carried out a final efficacy assessment at the end of week 12. Volunteers’ final overall efficacy assessment was recorded in a self-administered questionnaire. Adverse events were identified through examination, interview and collection of comments in patients’ questionnaires.Results  Treatment with the C. indicum extract-based cream resulted in significant improvement (P 〈 0.05) in severity of erythema, overall rosacea severity compared to baseline and placebo, and investigator and patient overall efficacy assessment scores (P = 0.046 and P = 0.001, respectively) compared with placebo scores. Adverse reactions were mild, and did not differ between the C. indicum extract-based cream and the placebo groups.Conclusion  Chrysanthellum indicum extract-based cream is an effective and well-tolerated topical agent for the treatment of moderate rosacea. The mode of action of the active ingredient suggests that additional efficacy might be expected from combination with other topical treatments.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 34 (1962), S. 714-715 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 5 (1993), S. 0 
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The electrophysiological action of thyrotropin-releasing hormone (TRH) on rat spinal motoneurons was studied in vitro using single-electrode voltage- and current-clamp techniques. In current-clamp conditions TRH elicited a slowly developing depolarization, associated with a large input resistance increase and sustained neuronal firing; the primary metabolites of TRH were ineffective. Under voltage-clamp conditions in the presence of tetrodotoxin, TRH evoked a large inward current (ITRH; peaking at approximately –40 mV) associated with a large input conductance fall. Only 44% of cells displayed ITRH reversal; when the chord conductance values of these cells were plotted against membrane potential, a bell-shaped relation occurred, indicating voltage-dependent block by TRH of a persistent conductance active over a wide range of membrane potentials. ITRH reversal values were shifted to more positive levels in high K+ solution in Nernstian fashion; hence a large proportion of the TRH response is suggested to be mediated by the block of a K+ conductance (IK(T)). IK(T) (and its voltage-dependent block by TRH) was resistant to certain K+ channel antagonists (tetraethylammonium, Cs+, 4-aminopyridine or apamin), but was depressed by Ba2+. The Ba2+-resistant fraction of ITRH was attenuated by Cd2+, Mn2+ or Co2+, indicating that it probably involved a Ca2+-sensitive inward current. Concomitant application of Ba2+ and Cd2+ induced a near-total block of the response to TRH. It is suggested that suppression of IK(T), associated with the onset of a Ca2+-sensitive current, can explain the excitatory effect of TRH on rat spinal motoneurons.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of food science & technology 15 (1980), S. 0 
    ISSN: 1365-2621
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Three practical means of overcoming the problem of the production of acceptable bread from storage-deteriorated flour have been devised. These comprise (1) the use of extra fat in breadmaking, (2) the use of extra yeast to increase proof volume at constant time, and (3) extending proof-time. The first two of these methods are acceptable for use commercially and have been tested successfully in commercial as well as laboratory scale trials. The third method may be difficult to apply in automatic plant bakeries. Additives which were ineffective included gluten, soya, skimmed milk powder, and glyceryl monostearate. Other changes proving ineffectual included increased dough temperature, increased oxidant level and variations in dough water levels.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Greece and Rome 40 (1993), S. 31-47 
    ISSN: 0017-3835
    Source: Cambridge Journals Digital Archives
    Topics: Archaeology , Classical Studies
    Notes: A great deal has been written recently on Aristophanes, and the Achamians in particular; inevitably, this has not produced agreement on how to interpret the plays. Among the questions to which different answers are still being given, and probably always will be, are the following: How far did Aristophanes seek to persuade the Athenians of his own political views, whatever they may have been? If there was a conflict between the presentation of his political views and the development of comic inventions or the desire to win the prize, which took precedence? Did the Athenians expect serious political persuasion in their comedies, and was Aristophanes innovative or traditional in these respects? More particularly, what were Aristophanes' attitudes to the Peloponnesian War? Did they change? How far did he seek to push a particular view in favour of making peace in any of the surviving three so-called peace plays?
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Greece and Rome 33 (1986), S. 210-213 
    ISSN: 0017-3835
    Source: Cambridge Journals Digital Archives
    Topics: Archaeology , Classical Studies
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Greece and Rome 33 (1986), S. 90-93 
    ISSN: 0017-3835
    Source: Cambridge Journals Digital Archives
    Topics: Archaeology , Classical Studies
    Type of Medium: Electronic Resource
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