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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Histochemistry and cell biology 84 (1986), S. 600-608 
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A cytochemical study of gastric K+-stimulated p-nitrophenylphosphatase (K-NPPase) activity, corresponding to a K+-stimulated phosphoprotein phosphatase of H-K-ATPase system, has been made by a new cytochemical method. Sections of fixed guinea pig gastric mucosa in a mixture of 2% paraformaldehyde and 0.25% glutaraldehyde, were incubated with the incubation medium (1.0 M glycine-0.1 M KOH buffer, pH 9.0, 2.5 ml; 1.1 M KCl, 0.5 ml; 10 mM lead citrate dissolved in 50 mM KOH, 4 ml; levamisole, 6.0 mg; dimethyl sulfoxide, 2.0 ml; 0.1 M p-nitrophenylphosphate (Mg-salt), 1.0 ml; ouabain, 73.0 mg) for 30 min at room temperature. Under a light microscope the specific gastric K-NPPase reaction was distributed only in the parietal cells of the fundic glands. The electron microscopic cytochemistry showed that the gastric K-NPPase activity was localized on the membrane lining the apical surfaces, secretory canaliculi and tubulovesicles. On the other hand, ouabain-sensitive K-NPPase activity (Na-K-ATPase) was demonstrated to localize only in the basolateral membrane of parietal cells with Mayahara's method. These findings support the interrelationships between the apical surface membrane, secretory canalicular membrane and tubulovesicles, and the functional differentiation of the membrane between the secretory membrane and basolateral membrane.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 5 (1989), S. 1326-1331 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 4 (1988), S. 903-906 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1420-908X
    Keywords: Key words: Matrix metalloproteinase inhibitor — LPS induced-arthritis — Guinea pigs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: To evaluate the effect of a newly developed inhibitor of matrix metalloproteinases (MMPs), ONO-4817, on the degradation of cartilage in the guinea pig arthritis model.¶Materials: 42 guinea pigs were used in the arthritis model.¶Treatment: Lipopolysaccharide (LPS) was injected into guinea pig knee joints. The content of proteoglycan released in synovial cavity was measured as a marker of cartilage degradation. ONO-4817, dexamethasone or indomethacin were administered orally to the animals.¶Results: ONO-4817 showed a broad inhibitory activity against MMPs except MMP-1 and MMP-7. The oral administration of ONO-4817 dose-dependently suppressed the release of proteoglycan from the cartilage of the knee joints.¶Conclusion: This study suggests the possibility that a novel MMP inhibitor, ONO-4817 may have a therapeutic utility for MMP-related diseases.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0533
    Keywords: Anti-Leu 7 ; Four-step PAP method ; Oligodendroglioma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the four-step peroxidase-antiper-oxidase (PAP) method, the presence of the antigen recognized with anti-Leu 7 monoclonal antibody was investigated in paraffin-embedded human brain tissue and tumors. The antigen was demonstrated in the myelin sheaths, oligodendrocytes, and some choroid plexus cells in normal brain and in oligodendrogliomas, some astrocytomas and choroid plexus papillomas. The technique can be used to identify hormal and neoplastic oligodendrocytes.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 77 (1989), S. 244-253 
    ISSN: 1432-0533
    Keywords: Adenovirus type 12 ; Experimental tumor induction ; Embryonal neuroectodermal origin ; Peripheral neuro-and medulloepitheliomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Human adenovirus type 12 (Ad 12) was inoculated intraperitoneally, intrapleurally, intramuscularly or subcutaneously into newborn rodents. Tumors developed preferentially in the peritoneal cavities in 93.9% of the hamsters and 82.6% of the mice, but none in rats; in contrast to the high incidence of brain tumors in rats when the virus is injected intracranially. Serial section of peritoneal tissues and muscle of hamsters revealed multicentric microtumors with a close relation to peripheral nerve fibers 10 to 35 days after virus inoculation. Histologically, most tumors consisted of closely packed, irregularly arranged, small spindle or tadpole-shaped cells. However, divergent morphological differentiation showing palisade arrangement of spongioblastic tumor cells forming trabeculae, pseudorosettes with or without central blood vessel, and true rosettes of immature ependymal (ependymoblastic) or medulloepithelial type were observed. No further differentiation was detected on immunohistochemical or electron microscopical examination of the tumor cells. The immature neuroepithelial phenotypes and the early stages of tumor development indicated that Ad 12 had a definite affinity for embryonic neuroepithelial elements that have migrated along the peripheral nerve fibers of newborn hamsters and mice, perhaps with cells of neural crest origin, and had induced primitive neuroectodermal tumors as observed in human peripheral neuroepithelioma and medulloepithelioma.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 78 (1989), S. 232-244 
    ISSN: 1432-0533
    Keywords: Adenovirus type 12 ; Experimental tumor induction ; Central nervous tumors ; Embryonal neuroectodermal origin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracranial inoculation with human adenovirus type 12 (Ad12) induced tumors multicentrically in the brain and spinal cord of 37.2% of hamsters, 30.2% of mice, and in the brains of 91.0% of rats. Brain tumors developed preferentially at the olfactory bulb, lateral ventricular horns, tapetum region, and ventral and dorso-caudal aspects of the fourth ventricle. In the spinal cord, tumor developed on the dorsal aspect and, in hamsters, at the root of the cauda equina. Microtumors were found almost invariably in the subependymal areas and occasionally in the leptomeninges. The histological and ultrastructural features indicated extremely undifferentiated neoplasms analogous with the intraperitoneal tumors described in the companion report. Closely packed small polygonal or tadpole-shaped tumor cells resembled the subependymal cell remnants of normal perinatal brains. Divergent differentiation consisted in an intermingling of a fascicular or palisading arrangement of spongioblastic cells, of incomplete perivascular pseudorosettes and of neuroblastic (Homer Wright type) rosettes. Neither distinct neuronal nor neurogial fibrils were demonstrated. True ependymoblastomatous and medulloepitheliomatous rosettes were rarely encountered. These results indicate that Ad12-induced tumors in the central nervous system are of embryonal neuroectodermal origin and with limited differentiation, leading to divergent phenotypes corresponding to medulloblastoma, neuroblastoma, primitive spongioblastoma, ependymoblastoma and, rarely, medulloepithelioma.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0533
    Keywords: Rat ; ENU ; Brain tumor ; Anti-Leu 7 ; GFAP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To clarify the chronologic changes in the cellular morphology of ENU-induced rat brain tumors, microtumors in the early stage were examined ummunohistochemically in comparison with macrotumors in the advanced stage. The tumor cells composing microtumors were negative for glial fibrillary acidic protein (GFAP), a specific marker of astrocylic cells, and Leu 7, a marker of oligodendrocytes, while cells of macrotumors were positive for either GFAP or Leu 7, showing characteristics of mature glial cells. The results suggested that the small round cells in the early devolopmental stage, generally thought to resemble mature oligodendrocytes, are not differentiated oligodendrocytes or astrocytes.
    Type of Medium: Electronic Resource
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