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  • 1
    Electronic Resource
    Electronic Resource
    Seasonality of vitamin D status and bone turnover in patients with Crohn's disease (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : While wintertime vitamin D deficiency has been well-documented in Crohn's disease patients, less is known about vitamin D status during summertime and whether a seasonal variation exists in bone turnover.Aims : To compare vitamin D status and bone turnover markers in Crohn's disease patients with age- and sex-matched controls during late-summer and late-winter.Subjects : Crohn's disease patients (n = 44; mean age 36.9 years, currently in remission) and matched controls (n = 44) were recruited from Cork University Hospital and Cork City area, respectively.Methods : Bloods were analysed for 25-hydroxyvitamin D, parathyroid hormone, bone-specific alkaline phosphatase, osteocalcin and urine analysed for N-telopeptides of type 1 collagen.Results : Serum 25-hydroxyvitamin D concentrations were significantly (P 〈 0.003) lower in Crohn's disease patients than in control subjects during both seasons. In Crohn's disease patients, serum 25-hydroxyvitamin D concentrations were lower (P 〈 0.0001) whereas serum parathyroid hormone, osteocalcin and bone-specific alkaline phosphatase and urinary N-telopeptides of type 1 collagen levels were higher (P 〈 0.001) during late-winter than late-summer.Conclusion : There were notable seasonal variations in vitamin D status and bone turnover markers in Crohn's disease patients. The impact of winter decline in vitamin D status and increase in bone turnover on long-term risk of osteopenia/osteoporosis in Crohn's disease patients is unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02446.x
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  • 2
    Electronic Resource
    Electronic Resource
    Lung cancer and exposure to tobacco smoke in the household
    Amsterdam : Elsevier
    Journal of Safety Research 22 (1991), S. 117-118 
    Details
    ISSN: 0022-4375
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4375(91)90021-M
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of sleep deprivation on the growth hormone response to the alpha-2 adrenergic receptor agonist, clonidine, in normal subjects (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 291-298 
    Details
    ISSN: 1435-1463
    Keywords: Sleep deprivation ; clonidine ; growth hormone ; adrenergic receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One night's sleep deprivation (SD) increased the growth hormone (GH) response to clonidine (2 ug/kg iv) in 11 normal men (p 〈 0.005). This finding may indicate that SD enhances alpha-2 adrenergic receptor function or that the GH response to GH releasing factor is increased by SD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01273189
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  • 4
    Electronic Resource
    Electronic Resource
    Hypothalamic-pituitary dopaminergic function in hepatic failure in man (1982)
    Springer
    Journal of neural transmission 53 (1982), S. 7-21 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The growth hormone (GH) response to apomorphine HCl (Apo) (0.75 mg sc), a dopamine (DA) receptor agonist, was assessed in healthy chronic alcoholics without cirrhosis (N=20) and in patients with alcoholic cirrhosis both with (N=5) and without (N=14) hepatic encephalopathy (HE). A significant number of cirrhotic patients with (P〈0.004) and without (P〈0.002) HE had an impaired GH response (peak increment〈5 ng/ml) compared with non-cirrhotic individuals. An impaired GH response was independent of the presence of HE. The magnitude of the GH response was unrelated to plasma oestrone, oestradiol, or progesterone concentrations but was significantly correlated with plasma testosterone levels (P〈0.01). None of the patients with an abnormally low testosterone concentration showed a normal GH response. None of the subjects with HE showed an arousal response to Apo. These results suggest that DA receptor sensitivity is decreased in liver cirrhosis and that this decrease is related to inadequate circulating levels of testosterone. The occurrence of HE is independent of impaired DA function. The present study only evaluates DA function in the hypothalamic-pituitary axis and therefore may not reflect changes in other regions of brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243516
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  • 5
    Electronic Resource
    Electronic Resource
    Intercellular bridges in ovaries of the newborn gerbil (1984)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 180 (1984), S. 29-35 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: This study describes intercellular bridges in the ovaries of neonatal gerbils. Electron microscopy has revealed the presence of true intercellular bridges, connecting oogonia or oocytes, in ovaries of newborn gerbils. The cytoplasm of the intercellular channels is similar to that of the connected cells, with mitochondria, smooth and rough endoplasmic reticulum, and free ribosomes present. Lysosomes are also occasionally present in the intercellular bridges and they may be involved in early waves of oocyte atresia. An electrondense substance, 350-500 Å thick, is located immediately beneath the unit membrane of the intercellular bridges. Accumulation of electron-dense material increases the thickness of the walls of the intercellular bridges, supporting and maintaining the patency of the channels. It is suggested that the intercellular channels probably allow the interchange of nutrients, organelles, and possibly regulatory materials as well.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051800105
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