Abstract
On the basis of previous data suggesting the involvement of cardiac histamine in ischemic heart disease (IHD), we evaluated plasma histamine (H) and creatine-kinase isoenzyme (CK-MB) level in cardiac and healthy subjects.
20 patients with acute myocardial infarction (AMI) (10 developing AMI in Hospital, thus making possible the detection of plasma H level before acute event), 10 patients with IHD not developing AMI and 10 presumably healthy subjects were admitted to the study.
15 of all patients with AMI showed a correlated H and CK-MB trend during AMI reaching the highest peak 24 hours after onset of pain.
7 of the patients with IHD who developed AMI in Hospital showed a slightly higher plasma H level, before AMI, than those with IHD who did not develop AMI.
A possible role of histamine in the pathogenesis of AMI is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
K. Levi, A.A. Wolff, D.A. Robertson andL.M. Graver, ‘IgE-Mediated hypersensitivity and ischemia as causes of endogenous cardiac histamine release’. Frontiers in Histamine Research. Based on an International Symposium held at Jouy-en-Josas (near Paris), France, 25–27 July 1984. InAdvances in the biosciences, vol. 51, p. 308 (EdsC.R. Ganellin andJ.C. Schwartz). Pergamon Press 1985.
R.W. Gristwood, D.A.A. Owen, P. Romanec andK.A. Sampford, ‘Histamine and myocardial dysfunction’. Frontiers in Histamine Research. Based on an International Symposium held at Jouy-en-Josas (near Paris), France, 25–27 July 1984. InAdvances in the biosciences, vol. 51, p. 315 (EdsC.R. Ganellin andJ.C. Schwartz). Pergamon Press 1985.
R. Ginsburg, M.R. Bristow, D.C. Harrison andE.B. Stinson,Studies with isolated human coronary arteries: some general observations, potential mediators of spasm, role of calcium antagonists, Chest78, 180S-186S (1980b).
R. Ginsburg, M.R. Bristow, N.E. Kantrowitz, D.S. Baim andD.C. Harrison,Histamine provocation of clinical coronary artery spasm: implications concerning pathogenesis of variant angina pectoris, Amer. Heart J.102, 819–822 (1981).
R. Ginsburg, M.R. Bristow andK. Davis,Receptors mechanisms in the human epicardial coronary artery, Circ. Res.55, 416–421 (1984).
S. Kalsner andR. Richards,Coronary arteries of cardiac patients are hyperreactive, Science3, 1435–1437 (1984).
P.F. Mannaioni andF. Moroni,Uptake, disposition and metabolism of histamine in isolated heart preparations, Br. J. Pharm.49, 457–465 (1973).
J. Moss, D.M. Philbin, C.W. Akins, C.E. Rosow, K. Kono andA. Triantafillou,Evaluation of and protection from morphine induced histamine release in man (abstr.), Circulation, 62, suppl. III:III-256 (1980).
M.R. Bristow, W.S. Sageman, R.H. Scott et al.Acute and chronic cardiovascular effects of doxorubicine in the dog: the cardiovascular pharmacology of drug-induced histamine release, J. Cardiovasc. Pharmacol.2, 487–515 (1980).
W. Lorenz, M.D. Reimann, H. Barth, D. Kirsche, R. Meyer, A. Duenidee andM. Hertzel,A sensitive and specific method for determination of histamine in human whole blood and plasma, Hoppe-Seylers)s Z. Physiol. Chem.353, 911–920 (1972).
U. Würzburg, N. Hennerich, H. Lang, W. Prellwitz, D. Neumeier andM. Knedel, Klin. Wschr.54, 357–360 (1976), C.E. 2732.
G. Mannino andS. Guidi, Mizar: un programma interattivo guidato di statistica sanitaria. InInformatica (Ed. DEDALO), Roma 1978.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zaca, F., Benassi, M.S., Ghinelli, M. et al. Myocardial infarction and histamine release. Agents and Actions 18, 258–261 (1986). https://doi.org/10.1007/BF01988036
Issue Date:
DOI: https://doi.org/10.1007/BF01988036