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Effects of papaverine, eupaverin and isoxsuprine on the electrical and mechanical activity of guinea-pig ‘taenia coli’

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Abstract

The effects of papaverine, eupaverin and isoxsuprine on the mechanical and electrical activity of guinea-pig ‘taenia coli’ were studied. All the drugs were effective against the acetylchline — or KCl — induced contraction, although only papaverine and eupaverin produced a clear relaxation of spontaneously active preparations. The spontaneous electrical activity associated with the normal muscular tone was poorly affected by isoxsuprine, but strongly inhibited by eupaverin and only transiently suppressed by papaverine. The restoration of a spontaneous electrical activity in the presence of papaverine was not affected by tetrodotoxin. Unlike eupaverin and isoxsuprine, papaverine induced a clear dissociation of mechanical and electrical activity after addition of acetylcholine of KCl. Other differences among the drugs tested were observed on electrically driven preparations and in the presence of calcium excess.

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Authors and Affiliations

  1. Institute of Pharmacology, University of Padua, Padua, Italy

    M. Ferrari, M. Furlanut & R. De Pirro

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  1. M. Ferrari
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  2. M. Furlanut
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  3. R. De Pirro
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Ferrari, M., Furlanut, M. & De Pirro, R. Effects of papaverine, eupaverin and isoxsuprine on the electrical and mechanical activity of guinea-pig ‘taenia coli’. Agents and Actions 2, 50–57 (1971). https://doi.org/10.1007/BF01965382

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  • DOI: https://doi.org/10.1007/BF01965382

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