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Action of the SP2–11 and SP3–11 fragments of substance P on rat peritoneal mast cells

  • Histamine Release
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Abstract

The ability of the SP fragments SP2–11 and SP3–11 to release histamine from rat peritoneal mast cells has been compared with that of the whole peptide. SP1–11 was found to be about 3.4 times more active than SP2–11 and about 10.4 times more active than SP3–11. The substance P antagonist [D-Pro4, D-Trp7,9,10] SP4–11 was equally effective at antagonizing the histamine releasing action of SP1–11, SP2–11 and SP3–11. Benzalkonium chloride was found to be a competitive antagonist of SP and SP3–11: the dissociation constants for the benzalkonium chloride-receptor interaction being about the same when either SP1–11 or SP3–11 was used as the agonist.

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Authors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK

    W. Piotrowski, M. Mead &  J. C. Foreman

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  1. W. Piotrowski
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  2. M. Mead
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  3. J. C. Foreman
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Piotrowski, W., Mead, M. & Foreman, J.C. Action of the SP2–11 and SP3–11 fragments of substance P on rat peritoneal mast cells. Agents and Actions 20, 178–180 (1987). https://doi.org/10.1007/BF02074662

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  • DOI: https://doi.org/10.1007/BF02074662

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