Skip to main content

Advertisement

SpringerLink
Log in

Adenosine and adenosine receptors in immune function. Minireview and meeting report

  • Immunosuppression and Inflammation
  • Published:
Agents and Actions Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. I. H. Fox and W. N. Kelley,The role of adenosine and 2′-deoxyadenosine in mammalian cells. Ann. Rev. Biochem.47, 655–686 (1978).

    Article  PubMed  Google Scholar 

  2. N. M. Kredich and M. S. Hershfield,Perturbations in S-Adenosylhomocyteine and S-Adenosylmethionine metabolism: Effects on transmethylation. Adv. Enzyme Reg.18, 181–191 (1980).

    Article  Google Scholar 

  3. A. N. Drury and A. Szent-Györgyi,Physiological activity of adenine compounds with especial reference to their action upon mammalian heart. J. Physiol. (London)68, 213–237 (1929).

    Google Scholar 

  4. R. M. Berne,Cardiac nucleotides in hypoxia: Possible role in regulation of coronary blood flow. Am. J. Physiol.204, 317–322 (1963).

    PubMed  Google Scholar 

  5. M. J. Cushley, A. E. Tattersfield and S. T. Holgate,Adenosine-induced bronchoconstriction in asthma. Amer. Rev. Respir. Dis.129, 380–384 (1984).

    Google Scholar 

  6. J. R. S. Arch and E. A. Newsholme,The control of the metabolism and the hormonal role of adenosine. Essays Biochem.14, 82–123 (1978).

    PubMed  Google Scholar 

  7. J. W. Daly, R. F. Bruns and S. H. Snyder,Adenosine receptors in the central nervous system: Relationship to the central actions of methylxanthines. Life Sciences28, 2083–2097 (1981).

    Article  PubMed  Google Scholar 

  8. Regulatory function of adenosine. Proceedings of the international symposium on adenosine. Charlottesville, VA, June 7–11, 1982 (Eds. R. M. Berne, T. W. Rall and R. Rubio) Martinus Nijhoff Publishers, Boston/The Hague/Dordrecht/Lancaster (1983).

    Google Scholar 

  9. E. R. Giblett, J. E. Anderson, F. Cohen, B. Pollara and H. J. Meuwissen,Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity. Lancetii, 1067–1069 (1972).

    Article  Google Scholar 

  10. B. S. Mitchell and W. N. Kelley,Purinogenic immunodeficiency diseases: Clinical features and molecular mechanisms. Annals Int. Med.92, 826–831 (1980).

    Google Scholar 

  11. L. F. Thompson and J. E. Seegmiller,Adenosine deaminase deficiency and severe combined immunodeficiency disease. Adv. Enzymol.51, 166–210 (1980).

    Google Scholar 

  12. D. W. Martin, Jr. and E. W. Gelfand,Biochemistry of diseases of immunodevelopment. Ann. Rev. Biochem.50, 845–877 (1981).

    Article  PubMed  Google Scholar 

  13. E. W. Gelfand and A. Cohen,Disorders of purine metabolism and immunodeficiency. InAdv. host defense mechanisms Vol. 2 (Eds. J. I. Gallin and A. S. Fauci) p. 43, Raven Press, New York 1983.

    Google Scholar 

  14. D. A. Carson, E. Lakow, D. B. Wasson and N. Kamatani,Lymphocyte dysfunction caused by deficiencies in purine metabolism. Immunol. Today2, 234–238 (1981).

    Article  Google Scholar 

  15. R. Hirschhorn, J. Grossman and G. Weissmann,Effect of cyclic 3′, 5′-adenosine monophosphate and theophylline on lymphocyte transformation. Proc. Soc. Exptl. Biol. Med.133, 1361–1365 (1970).

    Google Scholar 

  16. G. Wolberg, T. P. Zimmerman, K. Hiemstra, M. Winston and L. C. Chu,Adenosine inhibition of lymphocyte-mediated cytolysis: Possible role of cyclic adenosine monophosphate. Science187, 957–959 (1975).

    PubMed  Google Scholar 

  17. D. A. Carson and J. E. Seegmiller,Effect of adenosine deaminase inhibition upon human lymphocyte blastogenesis. J. Clin. Invest.57, 274–282 (1976).

    PubMed  Google Scholar 

  18. F. F. Snyder, J. Mendelsohn and J. E. Seegmiller,Adenosine metabolism in phytohemagglutinin-stimulated human lymphocytes. J. Clin. Invest.58, 654–666 (1976).

    PubMed  Google Scholar 

  19. D. A. Carson, D. B. Wasson, E. Lakow and N. Kamatani,Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase. Proc. Natl. Acad. Sci. USA79, 3848–3852 (1982).

    PubMed  Google Scholar 

  20. R. F. Kefford and R. M. Fox,Purine deoxynucleoside toxicity in nondividing human lymphoid cells. Cancer Res.42, 324–330 (1982).

    PubMed  Google Scholar 

  21. E. C. Moore and R. B. Hurlbert,Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors. J. Biol. Chem.241, 4802–4809 (1966).

    PubMed  Google Scholar 

  22. M. F. E. Siaw, B. S. Mitchell, C. A. Koller, M. S. Coleman and J. J. Hutton,ATP depletion as a consequence of adenosine demainase inhibition in man. Proc. natl. Acad. Sci. USA77, 6157–6161 (1980).

    PubMed  Google Scholar 

  23. L. Brox, A. Ng, E. Pollock and A. Belch,DNA strand breaks induced in human T-lymphocytes by the combination of deoxyadenosine and deoxycoformycin. Cancer Res.44, 934–937 (1984).

    PubMed  Google Scholar 

  24. H. E. Gruber, A. H. Cohen, S. G. Firestein, D. Redelman and H. G. Bluestein,Deoxy-ATP accumulation in adenosine deaminase-inhibited human B and T lymphocytes. InPurine and pyrimidine metabolism in man. Vol. V, Part A (Eds. W. L. Nyhan, L. F. Thompson and R. W. E. Watts) p. 503, Plenum Press, New York and London 1986.

    Google Scholar 

  25. A. Goday, H. A. Simmonds, L. D. Fairbanks and G. S. Morris,B-lymphocytes, thymocytes and platelets accumulate high dATP levels in simulated ADA deficiency. InPurine and pyrimidine metabolism in man. Vol V, Part A (Eds. W. L. Nyhan, L. F. Thompson and R. W. E. Watts) p. 515, Plenum Press, New York and London 1986.

    Google Scholar 

  26. G. Marone, M. Plaut and L. M. Lichtenstein,Characterization of a specific adenosine receptor on human lymphocytes. J. Immunol.121, 2153–2159 (1978).

    PubMed  Google Scholar 

  27. A. L. Schwartz, R. C. Stern and S. H. Polmar,Demonstration of an adenosine receptor on human lymphocytes in vitro and its possible role in the adenosine deaminase-deficient form of severe combined immunodeficiency. Clin. Immunol. Immunopathol.9, 499–505 (1978).

    Article  PubMed  Google Scholar 

  28. J. C. Bonnafous, J. Dornand, J. Favero and J. C. Mani,Lymphocyte membrane adenosine receptors coupled to adenylate cyclase. Properties and occurrence in various lymphocyte subclasses. J. Receptor Research2, 347–366 (1981/2).

    Google Scholar 

  29. C. S. Henney, H. R. Bourne and L. M. Lichtenstein,The role of cyclic 3′, 5′-adenosine monophosphate in the specific cytolytic activity of lymphocytes. J. Immunol.108, 1526–1534 (1972).

    PubMed  Google Scholar 

  30. T. B. Strom, A. Deisseroth, J. Morganroth, C. B. Carpenter and J. P. Merrill,Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase. Proc. Natl. Acad. Sci. USA69, 2995–2999 (1972).

    PubMed  Google Scholar 

  31. L. M. Lichtenstein, C. S. Henney, H. R. Bourne and W. B. Greenough, III,Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. J. Clin. Invest.52, 691–697 (1973).

    PubMed  Google Scholar 

  32. F. V. Chisari and T. S. Edgington,Human T lymphocyte ‘E’ rosette formation. 1. A process modulated by intracellular cAMP. J. Exp. Med.140, 1122–1126 (1974).

    Article  PubMed  Google Scholar 

  33. H. Bessler, M. Djaldetti, B. Kupfer and C. Moroz,Two T lymphocyte subpopulations isolated from human peripheral blood following “in vitro” treatment with adenosine. Biomedicine32, 66–71 (1980).

    PubMed  Google Scholar 

  34. S. Limatibul, A. Shore, H. M. Dosch and E. W. Gelfand,Theophylline modulation of E-rosette formation: An indicator of T-cell maturation. Clin. Exptl. Immunol.33, 503–513 (1978).

    Google Scholar 

  35. C. Moroz and R. H. Stevens,Suppression of immunoglobulin production in normal human B lymphocytes by two T-cell subsets distinguished following in vitro treatment with adenosine. Clin. Immunol. Immunopathol.15, 44–51 (1980).

    Article  PubMed  Google Scholar 

  36. R. E. Birch and S. H. Polmar,Induction of Fc γ receptors on a subpopulation of human T lymphocytes by adenosine and impromidine, an H 2-histamine agonist. Cell. Immunol.57, 455–467 (1981).

    Article  PubMed  Google Scholar 

  37. R. E. Birch, A. K. Rosenthal and S. H. Polmar,Pharmacological modification of immunoregulatory T lymphocytes. II. Modulation of T lymphocyte cell surface characteristics. Clin. Exptl. Immunol.48, 231–238 (1982).

    Google Scholar 

  38. R. E. Birch and S. H. Polmar,Adenosine induced immunosuppression: The role of the adenosine receptor-adenylate cyclase interaction in the alteration of T-lymphocyte surface phenotype and immunoregulatory function. Int. J. Immunopharm.8, 329–337 (1986).

    Article  Google Scholar 

  39. C. Londos and J. Wolff,Two distinct adenosine-sensitive sites on adenylate cyclase. Proc. Natl. Acad. Sci. USA74, 5482–5486 (1977).

    PubMed  Google Scholar 

  40. C. Londos, D. M. F. Cooper, W. Schlegel and M. Rodbell,Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: Basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis. Proc. Natl. Acad. Sci. USA75, 5362–5366 (1978).

    PubMed  Google Scholar 

  41. C. Londos, D. M. F. Cooper and J. Wolff,Subclasses of external adenosine receptors. Proc. Natl. Acad. Sci. USA77, 2551–2554 (1980).

    PubMed  Google Scholar 

  42. F. W. Smellie, J. W. Daly, T. V. Dunwiddie and B. J. Hoffer,The dextro and levorotatory isomers of n-phenylisopropyladenosine: Stereospecific effects on cyclic AMP-formation and evoked synaptic responses in brain slices. Life Sci.25, 1739–1748 (1979).

    Article  PubMed  Google Scholar 

  43. U. Schwabe and T. Trost,Characterization of adenosine receptors in rat brain by (−)[3 H]N 6-phenylisopropyladenosine. Naunyn-Schmiedeberg's Arch. Pharmacol.313, 179–187 (1980).

    Article  Google Scholar 

  44. M. Williams and E. A. Risley,Biochemical characterization of putative central purinergic receptors by using 2-chloro [3 H]adenosine, a stable analog of adenosine. Proc. natl. Acad. Sci. USA77, 6892–6896 (1980).

    PubMed  Google Scholar 

  45. R. F. Bruns, J. W. Daly and S. H. Snyder,Adenosine receptors in brain membranes: Binding of N 6-cyclohexyl-[3 H]adenosine and 1,3-diethyl-8-[3 H]phenylxanthine. Proc. Natl. Acad. Sci. USA77, 5547–5551 (1980).

    PubMed  Google Scholar 

  46. K. M. M. Murphy and S. H. Snyder,Adenosine receptors in rat testes: Labeling with 3 H-cyclohexyladenosine. Life Sci.28, 917–920 (1981).

    Article  PubMed  Google Scholar 

  47. T. Trost and U. Schwabe,Adenosine receptors in fat cells. identification by (−)-N 6-[3 H]phenylisopropyladenosine binding. Mol. Pharmacol.19, 228–235 (1981).

    PubMed  Google Scholar 

  48. I. H. Fox and L. Kurpis,Binding characteristics of an adenosine receptor in human placenta. J. Biol. Chem.258, 6952–6955 (1983).

    PubMed  Google Scholar 

  49. D. L. Marquardt, C. W. Parker and T. J. Sullivan,Potentiation of mast cell mediator release by adenosine. J. Immunol.120 871–878 (1978).

    PubMed  Google Scholar 

  50. S. P. Peters, E. S. Schulman, R. P. Schleimer, D. W. MacGlashan, Jr., H. H. Newball and L. M. Lichtenstein,Dispersed human lung mast cells. Pharmacologic aspects and comparison with human lung tissue fragments. Amer. Rev. Resp. Dis.126, 1034–1039 (1982).

    PubMed  Google Scholar 

  51. G. Marone, M. Triggiani, A. Kagey-Sobotka, L. M. Lichtenstein and M. Condorelli,Adenosine receptors on human basophils and lung mast cells. InPurine and pyrimidine metabolism in man. Vol V, Part B (Eds. W. L. Nyhan, L. F. Thompson and R. W. E. Watts) p. 35, Plenum Press, New York and London 1986.

    Google Scholar 

  52. M. C. Pike, N. M. Kredich and R. Snyderman,Requirement of S-adenosyl-l-methionine-mediated methylation for human monocyte chemotaxis. Proc. Natl. Acad. Sci. USA75, 3928–3932 (1978).

    PubMed  Google Scholar 

  53. G. Marone, L. L. Thomas and L. M. Lichtenstein,The role of agonists that activate adenylate cyclase in the control of cAMP metabolism and enzyme release by human polymorphonuclear leukocytes. J. Immunol.125, 2277–2283 (1980).

    PubMed  Google Scholar 

  54. B. N. Cronstein, S. B. Kramer, G. Weissmann and R. Hirschhorn,A new physiological function for adenosine: regulation of superoxide anion production. Trans. Assoc. Amer. Physicians96, 384–391 (1983).

    Google Scholar 

  55. B. N. Cronstein, S. B. Kramer, G. Weissmann and R. Hirschhorn,Adenosine: a physiological modulator of superoxide anion generation by human neutrophils. J. Exptl. Med.158, 1160–1177 (1983).

    Article  Google Scholar 

  56. B. N. Cronstein, S. B. Kramer, G. Weissmann and R. Hirschhorn,Adenosine deaminase is not required for the generation of superoxide anion. Clin. Immunol. Immunopathol.30, 495–499 (1984).

    Article  PubMed  Google Scholar 

  57. B. N. Cronstein, E. D. Rosenstein, S. B. Kramer, G. Weissmann and R. Hirschhorn,Adenosine: a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A 2 receptor on human neutrophils. J. Immunol.135, 1366–1371 (1985).

    PubMed  Google Scholar 

  58. M. A. Iannone, R. Reynolds-Vaughn, G. Wolberg and T. P. Zimmerman,Human neutrophils possess adenosine A 2 receptors. Fed. Proc.44, 580A (1985).

    Google Scholar 

  59. T. P. Zimmerman, C. J. Schmitges, G. Wolberg, R. D. Deeprose, G. S. Duncan, P. Cuatrecasas and G. B. Elion,Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes. Proc. Natl. Acad. Sci. USA77, 5639–5643 (1980).

    PubMed  Google Scholar 

  60. T. P. Zimmerman, M. Iannone and G. Wolberg,3-deazaadenosine. S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes. J. Biol. Chem.259, 1122–1126 (1984).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Pharmacology, Immunopharmacology Section, Warner-Lambert Pharmaceutical Research, 2800 Plymouth Road, 48105, Ann Arbor, MI

    R. B. Gilbertsen

Authors
  1. R. B. Gilbertsen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gilbertsen, R.B. Adenosine and adenosine receptors in immune function. Minireview and meeting report. Agents and Actions 22, 91–98 (1987). https://doi.org/10.1007/BF01968823

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01968823

Keywords

Search

Navigation