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Effect of antiphlogistics on blood-brain barrier in lymphostatic encephalopathic and in normal rats

  • Immunosuppression and Inflammation
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Abstract

Injection of the tremorigenic alkaloid harmine into lymphostatic encephalopathic rats leads to a longer duration of tremor and higher brain concentrations than in shamoperated controls.

In lymphostatic encephalopathic as well as in normal rats different antiphlogistics shorten the tremor duration and decrease harmine concentraion in brain.

The antiphlogistics do not influence the plasma concentration of harmine, its protein binding and its tremorend concentration in brain.

The effect of antiphlogistics in lymphostatic encephalopathic rats is considered as a consequence of the reduced blood-brain barrier permeability. Obviously in sick animals the blood-brain barrier permeability for harmine is not increased; the prolonged harmine tremor and the increased alkaloid concentration in the brain are consequences of the impaired cerebral lymphatic drainage only.

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  1. Abteilung für Pharmakologie, Medizinische Hochschule Lübeck, Ratzeburger Allee 160, D-2400, Lübeck, Federal Republic of Germany

    G. Back & G. Seidel

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  1. G. Back
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  2. G. Seidel
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Back, G., Seidel, G. Effect of antiphlogistics on blood-brain barrier in lymphostatic encephalopathic and in normal rats. Agents and Actions 5, 57–61 (1975). https://doi.org/10.1007/BF02027160

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  • DOI: https://doi.org/10.1007/BF02027160

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