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Influence of chlorpromazine on nuclear and cytoplasmic uptake of35S-methionine

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Résumé

Des rats ont été traités avec de la chlorpromazine et ont reçu en suite une seule injection de35S-méthionine. Des radioautographies des coupes histologiques ont montré que la chlorpromazine a un effect inhibitoire dans la synthèse de la protéine nucléaire et cytoplasmatique. Les cellules qui ont une grande vitesse de synthèse protéique sont les plus affectées.

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Authors and Affiliations

  1. Laboratory of Cell Physiology and Clínica Psiquiátrica, Medical School, University of São Paulo, Brazil

    J. Carneiro & A. C. S. Q. Cardoso

Authors
  1. J. Carneiro
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  2. A. C. S. Q. Cardoso
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Additional information

This investigation was supported by grants from the Rockefeller Foundation and Conselho Nacional de Pesquisas.

The authors wish to acknowledge the help of Prof. L. C. U.Junqueira for criticism and encouragement, and MissEdna Freymüller for her skilled technical assistance.

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Carneiro, J., Cardoso, A.C.S.Q. Influence of chlorpromazine on nuclear and cytoplasmic uptake of35S-methionine. Experientia 18, 220–222 (1962). https://doi.org/10.1007/BF02148310

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