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A negative inotropic response of cat atria to sympathetic nerve stimulation or norepinephrine

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Zusammenfassung

Isolierte, sympathisch innervierte Katzenvorhöfe wurden durch den rechten Nervus accelerans mit Impulsen von 1–5 msec Dauer und mit einer Frequenz von 0.5–60 Impulsen/sec stimuliert. In allen Präparaten wurde eine positiv chronotrope Wirkung beobachtet, während nur in 52% der Fälle eine inotrope Wirkung nachweisbar war. Bei 26% war die Kontraktionsstärke nicht beeinflusst, während bei 22% eine negativ inotrope Wirkung festgestellt wurde, für deren Variieren bis jetzt keine Erklärung gefunden werden konnte.

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Author notes

  1. F. H. Schneider

    Present address: Department of Pharmacology, University of Colorado, Denver, Colorado, USA

Authors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Conn, USA

    F. H. Schneider, R. Cysyk & C. N. Gillis

Authors
  1. F. H. Schneider
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  2. R. Cysyk
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  3. C. N. Gillis
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Additional information

Formerly pre-doctoral Fellow (U.S.P.H.S. Grant No. 5-T4-CA-5012).

Pre-doctoral Fellow (U.S.P.H.S. Grant No. 5-T4-CA-5012).

Established investigator of the American Heart Association.

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Schneider, F.H., Cysyk, R. & Gillis, C.N. A negative inotropic response of cat atria to sympathetic nerve stimulation or norepinephrine. Experientia 24, 252–254 (1968). https://doi.org/10.1007/BF02152801

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  • DOI: https://doi.org/10.1007/BF02152801

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