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Cooperation between the two myosin heads interacting with actin in presence of ADP in myofibrils

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Zusammenfassung

Alkylierung von 2 Thiolgruppen pro Myosin mit NEM bei 0°C in Gegenwart einer Diophosphatkette inaktiviert die K-ATPase vollständig.In Myofibrillen werden diese Thiolgruppen durch Rigor-≪interaction≫ beider Myosinköpfchen mit Actin vor Alkylierung geschützt. In Gegenwart von Mg-ADP tritt eine spezifische vom Rigor verschiedene ≪interaction≫ zwischen Myosin und Actin auf. Man muss annehemen, dass dabei nur 1 Myosinköpfchen ans Actin bindet und dass das andere Köpfchen ein ADP gebunden hat.

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Authors and Affiliations

  1. Pharmakologisches Institut der Universität Zürich, Gloriastrasse 32, CH-3006, Zürich, Switzerland

    M. C. Schaub, J. G. Watterson & P. G. Waser

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  1. M. C. Schaub
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  2. J. G. Watterson
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  3. P. G. Waser
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Schaub, M.C., Watterson, J.G. & Waser, P.G. Cooperation between the two myosin heads interacting with actin in presence of ADP in myofibrils. Experientia 29, 316–318 (1973). https://doi.org/10.1007/BF01926499

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  • DOI: https://doi.org/10.1007/BF01926499

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