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On the time course of thyrotropin suppression by high doses of thyroid hormones

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Summary

Basal and stimulated TSH decreased progressively. Basal TSH was suppressed below the detection limit of 0.4 μU/ml after 74 h in 2 of the T3 and all of the T4 treated indiduals. At this time, in both groups 3 individuals could be significantly stimulated by TRH (about 5% of the pretreatment stimulation). There was no significant difference in the time course of suppression obtained by T3 or T4, though plasma T3 levels in the T4 treated group were considerably lower.

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Authors and Affiliations

  1. Medizinische Universitäts-Poliklinik, Hospitalstrasse 3, D-69, Heidelberg, German Federal Republic, BRD

    M. Hüfner & K. -H. Gless

Authors
  1. M. Hüfner
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  2. K. -H. Gless
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Supported by the Deutsche Forschungsgemeinschaft

The excellent technical assistance of MissM. Knöpfle, MissU. Neun and Mr.G. Magin is gratefully acknowledged.

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Hüfner, M., Gless, K.H. On the time course of thyrotropin suppression by high doses of thyroid hormones. Experientia 32, 655–657 (1976). https://doi.org/10.1007/BF01990218

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  • DOI: https://doi.org/10.1007/BF01990218

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