Skip to main content
SpringerLink
Log in

Desmosomal abnormalities in the liver of methotrexate-treated psoriatics

  • Pharmacologica
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Electron microscopy of the liver of methotrexate-treated psoriatic patients revealed junctional abnormalities consisting of detachment of desmosomal plaques between hepatocytes. Mitochondria anchoring desmosomal microfilaments were frequently noted.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. Horvath, K. Kovacs and R. C. Ross, Archs Derm.108, 427 (1973).

    Article  CAS  Google Scholar 

  2. D. Hopwood and A. Nyfors, J. clin. Path.29 698 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. E. Horvath, F. Saibil, K. Kovacs, N. A. Kerenyi and R. C. Ross, submitted for publication.

  4. L. H. Bernstein and S. H. Wollman, J. Ultrastruct. Res.53, 87 (1975).

    Article  CAS  PubMed  Google Scholar 

  5. Z. Hruban, Y. Mochizuki, A. Slesers and H. P. Morris, Cancer Res.32, 853 (1972).

    CAS  PubMed  Google Scholar 

  6. C. J. McDonald, Int. J. Derm.14, 563 (1975).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, University of Toronto, St. Michael's Hospital, 30 Bond Street, M5B 1W8, Toronto

    E. Horvath, K. Kovacs, R. C. Ross, F. Saibil & N. A. Kerenyi

  2. Department of Medicine and Pathology, Sunnybrook Hospital, Toronto, Ontario, Canada

    E. Horvath, K. Kovacs, R. C. Ross, F. Saibil & N. A. Kerenyi

Authors
  1. E. Horvath
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Kovacs
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. C. Ross
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Saibil
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. A. Kerenyi
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgment. This work was supported in part by a grant from the Physicians' Services Incorporated Foundation, Toronto. The excellent technical assistance of Mrs Gezina Ilse and the invaluable secretarial help of Mrs Wanda Wlodarski are gratefully acknowledged

Rights and permissions

Reprints and permissions

About this article

Cite this article

Horvath, E., Kovacs, K., Ross, R.C. et al. Desmosomal abnormalities in the liver of methotrexate-treated psoriatics. Experientia 33, 1202–1204 (1977). https://doi.org/10.1007/BF01922329

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01922329

Keywords

Search

Navigation