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Circadian variation of the streptozotocin-diabetogenic effect in mice

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Summary

Streptozotocin was injected in normal mice every 4h, during the day. Greatest number of diabetic animals were obtained at 16.00 h (95%) and lowest at 08.00 h (50%). Magnitude of hyperglycemia also showed similar distribution. This effect might be considered when planning its use for both experimental and clinical purposes.

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Authors and Affiliations

  1. Facultad de Ciencias Médicas, Centro de Endocrinología Experimental y Aplicada (UNLP-CONICET), 60 y 120, 1900, La Plata, Argentina

    Silvia Candela, R. E. Hermandez & J. J. Gagliardino

Authors
  1. Silvia Candela
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  2. R. E. Hermandez
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  3. J. J. Gagliardino
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Additional information

This work was done with funds provided by Conicet, Secyt and Cediquifa.

Thanks are due to Dr W. E. Dulin for kindly provision of SZ and Mrs E. E. Gagliardino for technical assistance.

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Candela, S., Hermandez, R.E. & Gagliardino, J.J. Circadian variation of the streptozotocin-diabetogenic effect in mice. Experientia 35, 1256–1257 (1979). https://doi.org/10.1007/BF01963323

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