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DOCA administration increases renal phospholipase activity in the rat

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Summary

The phospholipase activity of renal tissue has been evaluated in controls and in DOCA treated rats. DOCA treated animal showed a higher than normal enzyme activity. Since a phospholipase is the key step in prostaglandin biosynthesis, it is suggested that the increased prostaglandin release promoted by mineraloactive steroids is mediated by an activation of this key enzyme.

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Authors and Affiliations

  1. Clinica Medica I, Università di Padova, Padova, Italy

    B. Baggio, D. Bordin, G. de Giorgi, S. Favaro, A. Antonello & A. Borsatti

Authors
  1. B. Baggio
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  2. D. Bordin
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  3. G. de Giorgi
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  4. S. Favaro
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  5. A. Antonello
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  6. A. Borsatti
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Additional information

This work has been partly supported by a grant from Consiglio Nazionale delle Ricerche.

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Baggio, B., Bordin, D., de Giorgi, G. et al. DOCA administration increases renal phospholipase activity in the rat. Experientia 36, 366–367 (1980). https://doi.org/10.1007/BF01952330

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