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Effect of tranexamic acid on progress of experimental tumours and on DNA-synthesis

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Summary

The fibrinolytic inhibitor tranexamic acid affects certain experimental tumours; it prolongs survival (Lewis lung adenocarcinoma), decreases tumour weight (C3H breast carcinoma), and inhibits ascitic production (AH 130 rat hepatoma). However, it does not significantly influence DNA-synthesis in cell suspensions prepared from the same tumours.

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References

  1. J. Christman and G. Acs, Biochim. biophys. Acta340, 339 (1974).

    Article  CAS  PubMed  Google Scholar 

  2. D. Rifkin, J. Loeb, G. Morre and E. Reich, J. exp. Med.139, 1317 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. L. Svanberg and B. Åstedt, Annls Chir. Gynaec.65, 405 (1976).

    CAS  Google Scholar 

  4. B. Åstedt and L. Holmberg, Nature261, 595 (1976).

    Article  PubMed  Google Scholar 

  5. B. Åstedt, in: Proc. Conf. Biological Markers in Leesburg, Virginia, p. 481. Elsevier, North-Holland, New York 1978.

    Google Scholar 

  6. G. Weiss and F.K. Beller, Am. J. Obstet. Gynec103, 1023 (1969).

    Article  CAS  PubMed  Google Scholar 

  7. C.R. Pick and D.B. Cater, Br. J. exp. Path.52, 14 (1971).

    CAS  Google Scholar 

  8. L. Svanberg, F. Linell, M. Pandolfi and B. Åstedt, Acta path. microbiol. scand.83A, 193 (1975).

    Google Scholar 

  9. L. Håkansson and C. Tropé, Acta path. microbiol. scand.81A, 552 (1973).

    Google Scholar 

  10. U. Borell, Acta endocr.9, 141 (1952).

    CAS  PubMed  Google Scholar 

  11. G. Ceriotti, J. biol. Chem.198, 297 (1952).

    Article  CAS  PubMed  Google Scholar 

  12. S.L. Bonting and M. Jones, Archs Biochem.66, 340 (1957).

    Article  CAS  Google Scholar 

  13. S. Nordqvist, J. Endocr.48, 17 (1970).

    Article  CAS  PubMed  Google Scholar 

  14. H.-I. Peterson, A. Peterson and C.-M. Rudenstam, Acta. chir. scand., suppl. 394 (1968).

  15. H.-I. Peterson, Cancer Treatment Rev.4, 213 (1977).

    Article  CAS  Google Scholar 

  16. R.A.Q. O'Meara, Irish J. med. Sci.394, 474 (1958).

    Article  CAS  PubMed  Google Scholar 

  17. H.P. Schnebli and M.M. Burger, Proc. natl Acad. Sci. USA69, 3825 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. J.G. Collard and L.A. Smets, Exptl Cell Res.86, 75 (1974).

    Article  CAS  PubMed  Google Scholar 

  19. R. Verloes, G. Atassi, P. Dumont and L. Kanarek, Eur. J. Cancer14, 23 (1978).

    Article  CAS  Google Scholar 

  20. B. Åstedt, W. Mattsson and C. Tropé, Acta med. scand.201, 491 (1977).

    Article  PubMed  Google Scholar 

  21. B. Åstedt, I. Glifberg, W. Mattsson and C. Tropé, J. Am. med. Ass.238, 154 (1977).

    Article  Google Scholar 

  22. S. Thorsen, in: Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 3, p. 269, Raven Press, New York 1978.

    Google Scholar 

  23. L. Andersson, I.M. Nilsson, J.-E. Nihlén, U. Hedner, B. Granstrand and B. Melander, Scand. J. Haemat.2, 230 (1965).

    Article  CAS  PubMed  Google Scholar 

  24. O.D. Ratnoff and G.B. Naff, J. exp. Med.125, 337 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. V. Brade, A. Nicholson, D. Bitter-Suermann and U. Hadding, J. Immun.113, 1735 (1974).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Research Laboratory of the Department of Obstetrics and Gynecology, University Hospital, S-221 85, Lund, Sweden

    B. Åstedt & C. Tropé

  2. Department of Oncology, University Hospital, S-221 85, Lund, Sweden

    B. Åstedt & C. Tropé

Authors
  1. B. Åstedt
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  2. C. Tropé
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Additional information

Acknowledgment. This study was supported by grants from Malmö Allmänna Sjukhus and the Swedish Medical Research Council (B79-17X-04523-05B).

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Åstedt, B., Tropé, C. Effect of tranexamic acid on progress of experimental tumours and on DNA-synthesis. Experientia 36, 679–680 (1980). https://doi.org/10.1007/BF01970136

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  • DOI: https://doi.org/10.1007/BF01970136

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