Summary
Cleavage of the lactone ring of aflatoxin B1 results in a nonfluorescent compound that has greatly reduced biological activity. Mutagenicity, as measured by the Ames test, is reduced 450-fold compared to that of B1, and toxicity, as measured by the chick embryo test, is reduced 18-fold.
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Lee, L.S., Dunn, J.J., DeLucca, A.J. et al. Role of lactone ring of aflatoxin B1 in toxicity and mutagenicity. Experientia 37, 16–17 (1981). https://doi.org/10.1007/BF01965543
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DOI: https://doi.org/10.1007/BF01965543