Summary
We have studied the elimination kinetics of iopamidol employing radioactivation and radiochemical separation. This method offers the advantage of guaranteeing absolutely no interference by radiation with tissue distribution or elimination kinetics of the analyzed compound. Our results show that iopamidol does not cross the blood-brain barrier, has no effect on thyroid iodine uptake and does not accumulate in the liver.
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Acknowledgments. The authors wish to acknowledge use of the nuclear reactor offered by Prof. Orvini, L.E.N.A., Pavia and the invaluable suggestions provided by Prof. G. Cittadini and by Dr M. Gallorini. Moreover the authors wish to acknowledge the accurate revision of the English draft offered by Dr S. Raffanti.
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Muratore, O., Saitta, S., Mallarini, G. et al. Elimination kinetics of iopamidol, a new water soluble nonionic radiographic contrast medium, analyzed by radioactivation. Experientia 39, 119–121 (1983). https://doi.org/10.1007/BF01960664
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DOI: https://doi.org/10.1007/BF01960664