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Inhibition of pig kidney dopa decarboxylase by coenzyme-5-hydroxytryptophan adducts

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Summary

The effect of N-(5′-phosphopyridoxyl)-L-5-hydroxytryptophan, N-(5′-phosphopyridoxyl)-D-5-hydroxytryptophan and N-(5′-phosphopyridoxyl)-5-hydroxytryptamine on the reactivation of apoDopa decarboxylase to holoenzyme has been investigated. The different degree of inhibition exerted by these adducts has been interpreted on the basis of a different orientation of the 2 isomers of 5-HTP at the active of Dopa decarboxylase.

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Literatur

  1. Ayling, J.E., and Snell, E.E., Biochemistry7 (1968) 1616.

    Article  CAS  PubMed  Google Scholar 

  2. Bayon, A., Possani, L.D., and Tapia, R., J. Neurochem.29 (1977) 1629.

    Google Scholar 

  3. Borri Voltattorni, C., Orlacchio, A., Giartosio, A., Conti, F., and Turano, C., Eur. J. Biochem.53 (1975) 151.

    Article  CAS  Google Scholar 

  4. Orlacchio, A., Borri Voltattorni, C., and Turano, C., Biochem. J.185 (1980) 41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Raso, V., and Stollar, B.D., Biochemistry14 (1975) 591.

    Article  CAS  PubMed  Google Scholar 

  6. Heller, J.S., Canellakis, E.S., Bussolotti, D.L., and Coward, J.K., Biochim. biophys. Acta403 (1975) 197.

    Article  CAS  PubMed  Google Scholar 

  7. Tunnicliff, G., Ngo, T.T., and Barbeau, A., Experientia33 (1977) 20.

    Article  CAS  PubMed  Google Scholar 

  8. Borri Voltattorni, C., Minelli, A., and Turano, C., Boll. Soc. ital. Biol. sper.47 (1971) 700.

    CAS  PubMed  Google Scholar 

  9. Rudd, E.A., and Thanassi, J.W., Biochemistry20 (1981) 7469.

    Article  CAS  PubMed  Google Scholar 

  10. Christenson, J.G., Dairman, W., and Udenfriend, S., Archs Biochem. Biophys.141 (1970) 356.

    Article  CAS  Google Scholar 

  11. Borri Voltattorni, C., and Minelli, A., Bull. molec. Biol. Med.5 (1980) 52.

    Google Scholar 

  12. Barboni, E., Borri Voltattorni, C., D'Erme, M., Fiori, A., Minelli, A., and Rosei, M.A., Life Sci.31 (1982) 1519.

    Article  CAS  PubMed  Google Scholar 

  13. Borri Voltattorni, C., Minelli, A., and Dominici, P., Biochemistry22 (1983) 2249.

    Article  Google Scholar 

  14. Ikawa, M., Archs Biochem. Biophys.118 (1967) 497.

    Article  CAS  Google Scholar 

  15. Borri Voltattorni, C., Minelli, A., Vecchini, P., Fiori, A., and Turano, C., Eur. J. Biochem.93 (1979) 181.

    Article  CAS  Google Scholar 

  16. Borri Voltattorni, C., Minelli, A., and Turano, C., FEBS Lett.17 (1971) 231.

    Article  CAS  Google Scholar 

  17. Charteris, A., and John, A., Analyt. Biochem.66 (1975) 365.

    Article  CAS  PubMed  Google Scholar 

  18. Dunathan, H.C., Proc. natl Acad. Sci. USA55 (1966) 712.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Institutes of Biological Chemistry and Organic Chemistry, Faculty of Pharmacy, University of Perugia, I-06100, Perugia, Italy

    P. Dominici, M. Curini, A. Minelli & C. Borri Voltattorni

Authors
  1. P. Dominici
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  2. M. Curini
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  3. A. Minelli
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  4. C. Borri Voltattorni
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Additional information

This investigation was supported by a grant of Ministero Publica Istruzione.

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Dominici, P., Curini, M., Minelli, A. et al. Inhibition of pig kidney dopa decarboxylase by coenzyme-5-hydroxytryptophan adducts. Experientia 40, 834–835 (1984). https://doi.org/10.1007/BF01951979

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  • DOI: https://doi.org/10.1007/BF01951979

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