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Interaction of smooth muscle relaxant drugs with calmodulin and cyclic nucleotide phosphodiesterase

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Summary

Some smooth muscle relaxant drugs with an unknown mechanism of action have been tested for their interaction with calmodulin and with calmodulin-induced cyclic nucleotide phosphodiesterase (PDE) activity. The affinity of these drugs for calmodulin does not parallel their inhibitory effect on the calmodulin activation of PDE. The lack of parallelism could be due to a binding of the drugs to different sites on calmodulin; furthermore a binding of papaverine, octylonium bromide and felodipine to PDE molecule, might also be considered to explain their inhibitory effect on PDE basal activity. The myolytic effect of octylonium bromide and pinaverium bromide may be due to their interaction with calmodulin-dependent systems.

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Authors and Affiliations

  1. Institute of Biological Chemistry, Faculty of Medicine, University of Pisa, I-56100, Pisa, Italy

    S. Ronca-Testoni, S. Hrelia, G. Hakim & C. A. Rossi

  2. Institute of Biological Chemistry, Faculty of Pharmacy, University of Bologna, I-40100, Bologna, Italy

    S. Ronca-Testoni, S. Hrelia, G. Hakim & C. A. Rossi

Authors
  1. S. Ronca-Testoni
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  2. S. Hrelia
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  3. G. Hakim
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  4. C. A. Rossi
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Ronca-Testoni, S., Hrelia, S., Hakim, G. et al. Interaction of smooth muscle relaxant drugs with calmodulin and cyclic nucleotide phosphodiesterase. Experientia 41, 75–76 (1985). https://doi.org/10.1007/BF02005883

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  • DOI: https://doi.org/10.1007/BF02005883

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